<abstract xmlns="http://www.w3.org/1999/xhtml"><sec><h3>Background</h3><p>Association between early diagnosis of chronic kidney disease (CKD) and low morbidity and mortality rate has been proven. Thus, tools for early CKD diagnosis are vital. Ultrasonography has been widely used to diagnose and monitor the progression of CKD.</p></sec><sec><h3>Objectives</h3><p>To determine the performance of selected renal ultrasonographic parameters for the diagnosis of early CKD.</p></sec><sec><h3>Methods</h3><p>In a cohort of patients diagnosed with CKD (n = 100), diagnostic performance of ultrasonographically measured renal length (RL), renal cortical thickness (RCT), and parenchymal thickness (PT) was determined using receiver operating curve analysis; correlation of each parameter with the associated comorbidities and serum creatinine (Scr) levels was also determined. Severity of CKD was graded with estimated glomerular filtration rates (eGFR).</p></sec><sec><h3>Results</h3><p>Of all patient participants, 85 had severity grades 2 or 3. Mean (standard deviation) Scr was 1.88 (0.60) mg/dL; eGFR was 43.3 (11.85) mL/min/1.73 m<sup>2</sup>. RL was 9.01 (0.83) cm, PT was 1.32 (0.22) cm, and RCT was 6.0 (0.10) mm. PT and RCT were positively correlated with eGFR (<italic>P</italic> = 0.01 and 0.002, respectively). Early CKD was better predicted by PT (area under the curve (AUC) 0.735; 82% sensitivity; 30% specificity; 68% positive predictive value (PPV)) and RCT (AUC 0.741; 82% sensitivity; 48% specificity; 51% PPV); severe CKD was better predicted by RL (AUC 0.809; 67% sensitivity; 26% specificity, 45% PPV; 13% negative predictive value).</p></sec><sec><h3>Conclusion</h3><p>Index ultrasonic parameters show a diagnostic role in different stages of CKD. The index ultrasound and biochemical parameters showed a complementary role in predicting renal dysfunction.</p></sec></abstract>

BackgroundAssociation between early diagnosis of chronic kidney disease (CKD) and low morbidity and mortality rate has been proven. Thus, tools for early CKD diagnosis are vital. Ultrasonography has been widely used to diagnose and monitor the progression of CKD.ObjectivesTo determine the performance of selected renal ultrasonographic parameters for the diagnosis of early CKD.MethodsIn a cohort of patients diagnosed with CKD (n = 100), diagnostic performance of ultrasonographically measured renal length (RL), renal cortical thickness (RCT), and parenchymal thickness (PT) was determined using receiver operating curve analysis; correlation of each parameter with the associated comorbidities and serum creatinine (Scr) levels was also determined. Severity of CKD was graded with estimated glomerular filtration rates (eGFR).ResultsOf all patient participants, 85 had severity grades 2 or 3. Mean (standard deviation) Scr was 1.88 (0.60) mg/dL; eGFR was 43.3 (11.85) mL/min/1.73 m2. RL was 9.01 (0.83) cm, PT was 1.32 (0.22) cm, and RCT was 6.0 (0.10) mm. PT and RCT were positively correlated with eGFR (P = 0.01 and 0.002, respectively). Early CKD was better predicted by PT (area under the curve (AUC) 0.735; 82% sensitivity; 30% specificity; 68% positive predictive value (PPV)) and RCT (AUC 0.741; 82% sensitivity; 48% specificity; 51% PPV); severe CKD was better predicted by RL (AUC 0.809; 67% sensitivity; 26% specificity, 45% PPV; 13% negative predictive value).ConclusionIndex ultrasonic parameters show a diagnostic role in different stages of CKD. The index ultrasound and biochemical parameters showed a complementary role in predicting renal dysfunction.

Diagnostic performance of renal ultrasonography in detecting chronic kidney disease of various severity

Department of Anatomy, Faculty of Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

BackgroundAssociation between early diagnosis of chronic kidney disease (CKD) and low morbidity and mortality rate has been proven. Thus, tools for early CKD...

Diagnostic performance of renal ultrasonography in detecting chronic kidney disease of various severity

Article Category: Original article

Published Online: Oct 31, 2020

Page range: 195 - 202

DOI: https://doi.org/10.1515/abm-2020-0028

Keywords
creatinine, kidney cortex, renal insufficiency, chronic, renal parenchyma, ultrasonography

© 2020 Iroshani Kodikara et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Diagnostic performance of renal ultrasonography in detecting chronic kidney disease of various severity

Article Category: Original article

Published Online: Oct 31, 2020

Page range: 195 - 202

DOI: https://doi.org/10.1515/abm-2020-0028

Keywordscreatinine, kidney cortex, renal insufficiency, chronic, renal parenchyma, ultrasonography

© 2020 Iroshani Kodikara et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
creatinine, kidney cortex, renal insufficiency, chronic, renal parenchyma, ultrasonography