<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) is a sophisticated transcription factor that is particularly important in the inflammatory response, but it regulates more than 400 individual and dependent genes for parts of the apoptotic, angiogenic, and proliferative, differentiative, and cell adhesion pathways. NF-κB function is directly inhibited by the binding of inhibitor of κB (IκB), and the imbalance between NF-κB and IκB has been linked to the development and progression of cancer and a variety of inflammatory disorders. These observations might broaden the horizon of current knowledge, particularly on the pathogenesis of inflammatory diseases considering the roles of NF-κB and IκB. In this context, we focus this narrative review on a comparative discussion of our findings with other literature regarding variations of <italic>NFKB1</italic> and <italic>NFKB1A</italic> and their association with susceptibility to widespread inflammatory disorders (such as atherosclerosis, morbid obesity, Behçet syndrome, Graves disease, Hashimoto disease) and common cancers (such as gliomas).</p></abstract>

Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) is a sophisticated transcription factor that is particularly important in the inflammatory response, but it regulates more than 400 individual and dependent genes for parts of the apoptotic, angiogenic, and proliferative, differentiative, and cell adhesion pathways. NF-κB function is directly inhibited by the binding of inhibitor of κB (IκB), and the imbalance between NF-κB and IκB has been linked to the development and progression of cancer and a variety of inflammatory disorders. These observations might broaden the horizon of current knowledge, particularly on the pathogenesis of inflammatory diseases considering the roles of NF-κB and IκB. In this context, we focus this narrative review on a comparative discussion of our findings with other literature regarding variations of NFKB1 and NFKB1A and their association with susceptibility to widespread inflammatory disorders (such as atherosclerosis, morbid obesity, Behçet syndrome, Graves disease, Hashimoto disease) and common cancers (such as gliomas).

Functional variations of <italic>NFKB1</italic> and <italic>NFKB1A</italic> in inflammatory disorders and their implication for therapeutic approaches

Department of Medical Biology and Genetics, Faculty of Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Functional variations of  and  in inflammatory disorders and their implication for therapeutic approaches

Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) is a sophisticated transcription factor that is particularly important in the inflammatory...

Functional variations of NFKB1 and NFKB1A in inflammatory disorders and their implication for therapeutic approaches

Article Category: Review

Published Online: Aug 04, 2020

Page range: 47 - 57

DOI: https://doi.org/10.1515/abm-2020-0008

Keywords
I-kappa B proteins, inflammation mediators, neoplasms, NF-kappa B, polymorphism, single nucleotide

© 2020 Gonul Kanigur-Sultuybek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Functional variations of NFKB1 and NFKB1A in inflammatory disorders and their implication for therapeutic approaches

Article Category: Review

Published Online: Aug 04, 2020

Page range: 47 - 57

DOI: https://doi.org/10.1515/abm-2020-0008

KeywordsI-kappa B proteins, inflammation mediators, neoplasms, NF-kappa B, polymorphism, single nucleotide

© 2020 Gonul Kanigur-Sultuybek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
I-kappa B proteins, inflammation mediators, neoplasms, NF-kappa B, polymorphism, single nucleotide