<abstract xmlns="http://www.w3.org/1999/xhtml"><sec><h3>Background</h3><p>Multidrug-resistant bacteria are becoming more hazardous day by day for human health all over the world, and the scientific community is trying hard to resolve this issue by various approaches. One of the very common approaches is to bind drugs to nanoparticles and study enhanced antibacterial properties.</p></sec><sec><h3>Objective</h3><p>To compare simultaneously different types of nanoparticles, their concentration, bacterial strains and their incubation time intervals for each of the selected drug combination.</p></sec><sec><h3>Methods</h3><p>We have selected the most commonly used gold and silver nanoparticles and few examples from fluoroquinolone antibiotics to make their conjugates and study their efficacy against multidrug-resistant <italic>E. coli</italic> and <italic>S. aureus</italic> strains simultaneously, at different incubation time intervals and different concentration of nanoparticles.</p></sec><sec><h3>Results</h3><p>Gold nanoparticle hybrids do not show any significant effect. Silver nanoparticle hybrids show far better results, even at extremely low concentrations.</p></sec><sec><h3>Conclusions</h3><p>This unique and simple approach allows us to know the exact time intervals and concentration required for each nanoparticle combination to control the growth for any specific strain. This approach can be extended to any set of nanoparticles, drugs and bacterial strains for comparative purposes.</p></sec></abstract>

BackgroundMultidrug-resistant bacteria are becoming more hazardous day by day for human health all over the world, and the scientific community is trying hard to resolve this issue by various approaches. One of the very common approaches is to bind drugs to nanoparticles and study enhanced antibacterial properties.ObjectiveTo compare simultaneously different types of nanoparticles, their concentration, bacterial strains and their incubation time intervals for each of the selected drug combination.MethodsWe have selected the most commonly used gold and silver nanoparticles and few examples from fluoroquinolone antibiotics to make their conjugates and study their efficacy against multidrug-resistant E. coli and S. aureus strains simultaneously, at different incubation time intervals and different concentration of nanoparticles.ResultsGold nanoparticle hybrids do not show any significant effect. Silver nanoparticle hybrids show far better results, even at extremely low concentrations.ConclusionsThis unique and simple approach allows us to know the exact time intervals and concentration required for each nanoparticle combination to control the growth for any specific strain. This approach can be extended to any set of nanoparticles, drugs and bacterial strains for comparative purposes.

A new methodology for simultaneous comparison and optimization between nanoparticles and their drug conjugates against various multidrug-resistant bacterial strains

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

BackgroundMultidrug-resistant bacteria are becoming more hazardous day by day for human health all over the world, and the scientific community is trying hard...

A new methodology for simultaneous comparison and optimization between nanoparticles and their drug conjugates against various multidrug-resistant bacterial strains

Article Category: Technical report

Published Online: Mar 31, 2020

Page range: 149 - 162

DOI: https://doi.org/10.1515/abm-2019-0054

Keywords
anti-bacterial agents, colloidal silver, drug resistance, fluoroquinolones, gold colloid, metal nanoparticles

© 2019 Ahson Jabbar Shaikh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

A new methodology for simultaneous comparison and optimization between nanoparticles and their drug conjugates against various multidrug-resistant bacterial strains

Article Category: Technical report

Published Online: Mar 31, 2020

Page range: 149 - 162

DOI: https://doi.org/10.1515/abm-2019-0054

Keywordsanti-bacterial agents, colloidal silver, drug resistance, fluoroquinolones, gold colloid, metal nanoparticles

© 2019 Ahson Jabbar Shaikh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
anti-bacterial agents, colloidal silver, drug resistance, fluoroquinolones, gold colloid, metal nanoparticles