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Incretin levels in patients with hypothyroidism and the evaluation of incretin levels alterations with treatment


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Plasma GLP-1 and GIP levels in patients in the control group and in patients with hypothyroidism before treatment and hypothyroidism after treatment

Laboratory parametersControl (n = 13)Hypothyroidism before treatment (n = 13)Hypothyroidism after treatment (n = 13)P (control vs hypothyroidism before treatment)P (hypothyroidism before vs after treatment)
GLP-1 levels (pg/ml)
Baseline3.88 ± 1.543.90 ± 1.474.12 ± 1.640.930.67
30th min5.63 ± 1.745.58 ± 1.936.01 ± 2.400.830.51
60th min4.9 ± 1.75.0 ± 2.15.16 ± 2.090.740.59
90th min4.47 ± 1.735.67 ± 1.855.53 ± 2.210.170.64
120th min3.87 ± 1.524.50 ± 1.015.04 ± 2.150.290.15
GIP levels (pg/ml)
Baseline44.5 ± 28.955.1 ± 18.753.4 ± 15.30.590.74
30th min81.1 ± 31.969.1 ± 22.687.1 ± 21.90.890.19
60th min85.9 ± 47.079.1 ± 32.783.6 ± 20.10.940.14
90th min96.5 ± 42.775.8 ± 26.474.2 ± 16.50.380.62
120th min64.5 ± 32.968.4 ± 33.158.0 ± 13.80.560.54

Plasma glucose and insulin levels in patients in the control group and in patients with hypothyroidism before treatment and hypothyroidism after treatmentResults are shown as mean ± standard deviation for normal distribution and median (minimum–maximum) for abnormal distribution.

Laboratory parametersControl (n = 13)Hypothyroidism before treatment (n = 13)Hypothyroidism after treatment (n = 13)P (control vs hypothyroidism before treatment)P (hypothyroidism before vs after treatment)
Glucose levels (mg/dl)
Baseline87.46 ± 6.8590.30 ± 3.8590.38 ± 7.240.1430.972
30th min141.65 ± 40.72145.92 ± 22.38148.15 ± 26.840.3430.753
60th min139.47 ± 45.79142.84 ± 27.09128.30 ± 28.310.6630.05
90th min117.01 ± 25.34121.69 ± 34.48118.61 ± 30.840.9390.610
120th min96.60 ± 30.78104.92 ± 31.67102.89 ± 29.950.5550.272
Insulin levels (mU/ml)
Baseline10.32 ± 4.798.24 ± 3.319.66 ± 4.510.1910.152
30th min54.74 (22.99–54.14 (23.7–229.6)56.35 (34.06–243.9)0.8580.422
294.3)
60th min56.32 (18.53–69.95 (23.87–160.7)53.43 (28.7–146.7)0.590.116
90th min226.6) 46.7 (7.9–121.8)42.75 (8.1–127.1)42.94 (9.36–208.5)0.9570.753
120th min27.65 (4.87–32.08 (7.61–18)31.34 (6.26–133.5)0.3170.249
132.7)
eISSN:
1875-855X
Language:
English
Publication timeframe:
6 times per year
Journal Subjects:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine