<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_abm-2019-0031_s_005_w2aab3b7b5b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Vulvar lesion is one of the common gynecologic problems.</p></sec><sec id="j_abm-2019-0031_s_006_w2aab3b7b5b1b6b1aab1c16b2Aa"><h3>Objective</h3><p>To assess the proportion of vulvar premalignant and malignant lesions in overall vulvar specimens and to evaluate the clinicopathologic features of each vulvar lesion in King Chulalongkorn Memorial Hospital (KCMH).</p></sec><sec id="j_abm-2019-0031_s_007_w2aab3b7b5b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>Pathological microscopic slides and medical records of the patients who underwent vulvar-related operations between January 1, 2002 and December 31, 2015 were reviewed. Patients’ clinical characteristics and pathologic features were evaluated and analyzed.</p></sec><sec id="j_abm-2019-0031_s_008_w2aab3b7b5b1b6b1aab1c16b4Aa"><h3>Results</h3><p>A total number of 700 patients were included. The proportion of malignant and premalignant lesions in overall vulvar specimens were 16.3% and 8.4%, respectively. Squamous cell carcinoma was the most common malignant vulvar lesion (48.2%), whereas vulvar intraepithelial neoplasia 1 (VIN1) (33.9%) was the most common lesion in the premalignant group. On multivariate analysis, four clinical factors were significantly associated with malignancy risk: increased parity (odds ratio [OR] 1.19, <italic>P</italic> = 0.010), large tumor size (OR 2.00, <italic>P</italic> &lt; 0.001), lesion at clitoris (OR 16.67, <italic>P</italic> = 0.002), and erythematous lesion (OR 2.41, <italic>P</italic> = 0.026).</p></sec><sec id="j_abm-2019-0031_s_009_w2aab3b7b5b1b6b1aab1c16b5Aa"><h3>Conclusions</h3><p>The proportion of malignant and premalignant lesions in overall vulvar specimens was 24.7% in KCMH. Increased parity, large tumor size, clitoris-located lesion, and erythematous lesion were associated with increasing malignancy risk.</p></sec></abstract>

BackgroundVulvar lesion is one of the common gynecologic problems.ObjectiveTo assess the proportion of vulvar premalignant and malignant lesions in overall vulvar specimens and to evaluate the clinicopathologic features of each vulvar lesion in King Chulalongkorn Memorial Hospital (KCMH).MethodsPathological microscopic slides and medical records of the patients who underwent vulvar-related operations between January 1, 2002 and December 31, 2015 were reviewed. Patients’ clinical characteristics and pathologic features were evaluated and analyzed.ResultsA total number of 700 patients were included. The proportion of malignant and premalignant lesions in overall vulvar specimens were 16.3% and 8.4%, respectively. Squamous cell carcinoma was the most common malignant vulvar lesion (48.2%), whereas vulvar intraepithelial neoplasia 1 (VIN1) (33.9%) was the most common lesion in the premalignant group. On multivariate analysis, four clinical factors were significantly associated with malignancy risk: increased parity (odds ratio [OR] 1.19, P = 0.010), large tumor size (OR 2.00, P < 0.001), lesion at clitoris (OR 16.67, P = 0.002), and erythematous lesion (OR 2.41, P = 0.026).ConclusionsThe proportion of malignant and premalignant lesions in overall vulvar specimens was 24.7% in KCMH. Increased parity, large tumor size, clitoris-located lesion, and erythematous lesion were associated with increasing malignancy risk.

Proportion of vulvar premalignant and malignant lesions in overall vulvar specimens in Thailand

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

BackgroundVulvar lesion is one of the common gynecologic problems.ObjectiveTo assess the proportion of vulvar premalignant and malignant lesions in overall...

Proportion of vulvar premalignant and malignant lesions in overall vulvar specimens in Thailand

Article Category: Brief communication (original)

Published Online: Oct 24, 2019

Page range: 281 - 286

DOI: https://doi.org/10.1515/abm-2019-0031

Keywords
carcinoma, squamous cell, vulvar diseases, vulvar neoplasms

© 2018 Ananya Trongpisutsak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Proportion of vulvar premalignant and malignant lesions in overall vulvar specimens in Thailand

Article Category: Brief communication (original)

Published Online: Oct 24, 2019

Page range: 281 - 286

DOI: https://doi.org/10.1515/abm-2019-0031

Keywordscarcinoma, squamous cell, vulvar diseases, vulvar neoplasms

© 2018 Ananya Trongpisutsak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
carcinoma, squamous cell, vulvar diseases, vulvar neoplasms