<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_abm-2019-0023_s_004_w2aab3b7b3b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Plasma leptin is regulated by several factors, including growth hormone (GH), which influences the pathophysiology of obesity.</p></sec><sec id="j_abm-2019-0023_s_005_w2aab3b7b3b1b6b1aab1c16b2Aa"><h3>Objective</h3><p>To demonstrate the short-term effect of GH on plasma leptin levels in 3 conditions <italic>in vivo</italic> with the different amount of body fat mass.</p></sec><sec id="j_abm-2019-0023_s_006_w2aab3b7b3b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>Adult male Wistar rats were fed with standard chow or hypercaloric diet (HC). The HC rats were demonstrated as HC-feeding obese (HC-O) and HC-feeding resistant (HC-R) rats. Then, they were treated with GH or saline for 3 days. Basal plasma leptin levels were measured at 24 and 32 h. For meal-induced condition, all rats were fed for 2 hand plasma leptin was measured. Further 16-h fasting period, plasma leptin, insulin, and insulin sensitivity indexes were determined.</p></sec><sec id="j_abm-2019-0023_s_007_w2aab3b7b3b1b6b1aab1c16b4Aa"><h3>Results</h3><p>The short-term GH treatment decreased basal plasma leptin at 32 h after the first GH injection in HC-O rats. However, GH treatment had no effect on meal-induced plasma leptin in all rats. Furthermore, GH treatment attenuated fasting effect on plasma leptin in control and HC-R rats. The insulin resistance (IR) induced by the short-term GH treatment was demonstrated by higher fasting plasma insulin and the increased homeostasis model of IR in HC-R rats.</p></sec><sec id="j_abm-2019-0023_s_008_w2aab3b7b3b1b6b1aab1c16b5Aa"><h3>Conclusions</h3><p>The study demonstrates the important role of greater fat mass in HC-O rats, which results in decreased basal plasma leptin after short-term GH treatment. For meal-induced condition, GH had no effect on plasma leptin in all rats. Interestingly, GH could attenuate fasting effect on plasma leptin in rats that have lower fat mass.</p></sec></abstract>

BackgroundPlasma leptin is regulated by several factors, including growth hormone (GH), which influences the pathophysiology of obesity.ObjectiveTo demonstrate the short-term effect of GH on plasma leptin levels in 3 conditions in vivo with the different amount of body fat mass.MethodsAdult male Wistar rats were fed with standard chow or hypercaloric diet (HC). The HC rats were demonstrated as HC-feeding obese (HC-O) and HC-feeding resistant (HC-R) rats. Then, they were treated with GH or saline for 3 days. Basal plasma leptin levels were measured at 24 and 32 h. For meal-induced condition, all rats were fed for 2 hand plasma leptin was measured. Further 16-h fasting period, plasma leptin, insulin, and insulin sensitivity indexes were determined.ResultsThe short-term GH treatment decreased basal plasma leptin at 32 h after the first GH injection in HC-O rats. However, GH treatment had no effect on meal-induced plasma leptin in all rats. Furthermore, GH treatment attenuated fasting effect on plasma leptin in control and HC-R rats. The insulin resistance (IR) induced by the short-term GH treatment was demonstrated by higher fasting plasma insulin and the increased homeostasis model of IR in HC-R rats.ConclusionsThe study demonstrates the important role of greater fat mass in HC-O rats, which results in decreased basal plasma leptin after short-term GH treatment. For meal-induced condition, GH had no effect on plasma leptin in all rats. Interestingly, GH could attenuate fasting effect on plasma leptin in rats that have lower fat mass.

Evidence of growth hormone effect on plasma leptin in diet-induced obesity and diet-resistant rats

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

BackgroundPlasma leptin is regulated by several factors, including growth hormone (GH), which influences the pathophysiology of obesity.ObjectiveTo demonstrate...

Evidence of growth hormone effect on plasma leptin in diet-induced obesity and diet-resistant rats

Article Category: Brief communication (original)

Published Online: Oct 01, 2019

Page range: 219 - 228

DOI: https://doi.org/10.1515/abm-2019-0023

Keywords
adipose tissue, growth hormone, insulin resistance, leptin, obesity

© 2018 Likitnukul et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Evidence of growth hormone effect on plasma leptin in diet-induced obesity and diet-resistant rats

Article Category: Brief communication (original)

Published Online: Oct 01, 2019

Page range: 219 - 228

DOI: https://doi.org/10.1515/abm-2019-0023

Keywordsadipose tissue, growth hormone, insulin resistance, leptin, obesity

© 2018 Likitnukul et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
adipose tissue, growth hormone, insulin resistance, leptin, obesity