<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Multiple sclerosis (MS) is a common neurologic disorder that is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). Its etiology remains unknown. Several recent studies have found that decreased susceptibility to vitamin D deficiency is also associated with a decreased risk of MS. The role of vitamin D receptor (VDR) gene and its polymorphisms are highlighted as susceptible components. In this study, we aimed to identify the relationship between ApaI (rs7975232), BsmI (rs 1544410), and TaqI (rs731236) gene polymorphisms with MS. ApaI, BsmI, and TaqI genotypes were determined in 70 patients with MS and in 70 control subjects. DNA was isolated from blood samples, and then ApaI, BsmI and TaqI gene polymorphisms were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The distribution of BsmI and TaqI polymorphisms did not show any significant differences in MS patients and controls; however, increased A allele of ApaI polymorphism was found in MS patients. Our findings suggest that the ApaI gene polymorphism might be associated with MS. Investigation of a larger population and functional work on these gene structures and function in MS patients are recommended.</p></abstract>

Multiple sclerosis (MS) is a common neurologic disorder that is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). Its etiology remains unknown. Several recent studies have found that decreased susceptibility to vitamin D deficiency is also associated with a decreased risk of MS. The role of vitamin D receptor (VDR) gene and its polymorphisms are highlighted as susceptible components. In this study, we aimed to identify the relationship between ApaI (rs7975232), BsmI (rs 1544410), and TaqI (rs731236) gene polymorphisms with MS. ApaI, BsmI, and TaqI genotypes were determined in 70 patients with MS and in 70 control subjects. DNA was isolated from blood samples, and then ApaI, BsmI and TaqI gene polymorphisms were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The distribution of BsmI and TaqI polymorphisms did not show any significant differences in MS patients and controls; however, increased A allele of ApaI polymorphism was found in MS patients. Our findings suggest that the ApaI gene polymorphism might be associated with MS. Investigation of a larger population and functional work on these gene structures and function in MS patients are recommended.

Vitamin D receptor gene polymorphisms in multiple sclerosis disease: A case-control study

Canakkale State Hospital, Clinic of Neurology

Faculty of Medicine, Department of Neurology

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Multiple sclerosis (MS) is a common neurologic disorder that is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous...

Vitamin D receptor gene polymorphisms in multiple sclerosis disease: A case-control study

Data publikacji: 29 paź 2018

Zakres stron: 489 - 495

Otrzymano: 05 mar 2018

Przyjęty: 10 lip 2018

DOI: https://doi.org/10.2478/rrlm-2018-0028

Słowa kluczowe
multiple sclerosis, vitamin D, vitamin D receptor (VDR) gene polymorphism

© 2018 Suat Cakina et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Vitamin D receptor gene polymorphisms in multiple sclerosis disease: A case-control study

Data publikacji: 29 paź 2018

Zakres stron: 489 - 495

Otrzymano: 05 mar 2018

Przyjęty: 10 lip 2018

DOI: https://doi.org/10.2478/rrlm-2018-0028

Słowa kluczowemultiple sclerosis, vitamin D, vitamin D receptor (VDR) gene polymorphism

© 2018 Suat Cakina et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
multiple sclerosis, vitamin D, vitamin D receptor (VDR) gene polymorphism