Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L.

1K. Sayah, I. Marmouzi, H. Naceiri Mrabti, Y. Cherrah and M. E. A. Faouzi, Antioxidant activity and inhibitory potential of Cistus salviifolius (L.) and Cistus monspeliensis (L.) aerial parts extracts against key enzymes linked to hyperglycemia, BioMed. Res. Int. 2017 (2017) Article ID 2789482 (7 pages); https://doi.org/10.1155/2017/2789482Search in Google Scholar

2Y. Chebli, M. Chentouf, J. F. Cabaraux and S. El Otmani, Floristic composition, diversity, palatability, and forage availability of forest rangelands in the southern mediterranean region of northern Morocco, Land 12 (2023) Article ID 215 (18 pages); https://doi.org/10.3390/land12010215Search in Google Scholar

3A. Bouyahya, J. Abrini, A. Et-Touys, Y. Bakri and N. Dakka, Indigenous knowledge of the use of medicinal plants in the north-west of Morocco and their biological activities, Eur. J. Integr. Med. 13 (2017) 9–25; https://doi.org/10.1016/j.eujim.2017.06.004Search in Google Scholar

4G. Attaguile, Gastroprotective effect of aqueous extract of Cistus incanus L. in rats, Pharmacol. Res. 31 (1995) 29–32; https://doi.org/10.1016/1043-6618(95)80043-3Search in Google Scholar

5E. Yeşilada, I. Gürbüz and E. Ergun, Effects of Cistus laurifolius L. flowers on gastric and duodenal lesions, J. Ethnopharmacol. 55 (1997) 201–211; https://doi.org/10.1016/S0378-8741(96)01502-4Search in Google Scholar

6A. Stępień, D. Aebisher and D. Bartusik-Aebisher, Biological properties of Cistus species, Eur. J. Clin. Exp. Med. 16 (2018) 127–132; https://doi.org/10.15584/ejcem.2018.2.8Search in Google Scholar

7S. Rebensburg, M. Helfer, M. Schneider, H. Koppensteiner, J. Eberle, M. Schindler, L. Gürtler and R. Brack-Werner, Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins, Sci. Rep. 6 (2016) Article ID 20394 (15 pages); https://doi.org/10.1038/srep20394Search in Google Scholar

8M. Amensour, E. Sendra, J. A. Pérez-Alvarez, N. Skali-Senhaji, J. Abrini and J. Fernández-López, Antioxidant activity and chemical content of methanol and ethanol extracts from leaves of rock-rose (Cistus ladaniferus), Plant Foods Hum. Nutr. 65 (2010) 170–178; https://doi.org/10.1007/s11130-010-0168-2Search in Google Scholar

9I. Marmouzi, N. El Madani, Z. Charrouf, Y. Cherrah and M. Y. El Abbes Faouzi, Proximate analysis, fatty acids and mineral composition of processed Moroccan Chenopodium quinoa Willd. and antioxidant properties according to the polarity, Phytothérapie 13 (2015) 110–117; https://doi.org/10.1007/s10298-015-0931-5Search in Google Scholar

10L. A. Mařghitaş, O. G. Stanciu, D. S. Dezmirean, O. Bobiş, O. Popescu, S. Bogdanov and M. G. Campos, In vitro antioxidant capacity of honeybee-collected pollen of selected floral origin harvested from Romania, Food Chem. 115 (2009) 878–883; https://doi.org/10.1016/j.foodchem.2009.01.014Search in Google Scholar

11F. Amezouar, W. Badri, M. Hsaine, N. Bourhim and H. Fougrach, Évaluation des activités antioxy-dante et anti-inflammatoire de Erica arborea L. du Maroc, Pathol. Biol. 61 (2013) 254–258; https://doi.org/10.1016/j.patbio.2013.03.005Search in Google Scholar

12Z. Zhu, Y. Zhang, J. Wang, X. Li, W. Wang and Z. Huang, Sugaring-out assisted liquid-liquid extraction coupled with high performance liquid chromatography-electrochemical detection for the determination of 17 phenolic compounds in honey, J. Chromatogr. A 1601 (2019) 104–114; https://doi.org/10.1016/J.CHROMA.2019.06.023Search in Google Scholar

13B. Huang, H. Ke, J. He, X. Ban, H. Zeng and Y. Wang, Extracts of Halenia elliptica exhibit antioxidant properties in vitro and in vivo, Food Chem. Toxicol. 49 (2011) 185–190; https://doi.org/10.1016/j.fct.2010.10.015Search in Google Scholar

14H. J. D. Dorman and R. Hiltunen, Fe(III) reductive and free radical-scavenging properties of summer savory (Satureja hortensis L.) extract and subfractions, Food Chem. 88 (2004) 193–199; https://doi.org/10.1016/j.foodchem.2003.12.039Search in Google Scholar

15N. Bougandoura and N. Bendimerad, Evaluation de l’activité antioxydante des extraits aqueux et méthanolique de Satureja calamintha ssp.Nepeta (L.) Briq., Nat. Technol. 9 (2013) 14–19.Search in Google Scholar

16National Research Council, Guide for the Care and Use of Laboratory Animals, Vol. 184, National Academies Press, Washington DC 2011.Search in Google Scholar

17C. A. Winter, E. A. Risley and G. W. Nuss, Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs, Proc. Soc. Exp. Biol. Med. 111 (1962) 544–547; https://doi.org/10.3181/00379727-111-27849Search in Google Scholar

18A. Lekouaghet, A. Boutefnouchet, C. Bensuici, L. Gali, K. Ghenaiet and L. Tichati, In vitro evaluation of antioxidant and anti-inflammatory activities of the hydroalcoholic extract and its fractions from Leuzea conifera L. roots, South African J. Bot. 132 (2020) 103–107; https://doi.org/10.1016/j.sajb.2020.03.042Search in Google Scholar

19K. Sayah, L. Chemlal, I. Marmouzi, M. El Jemli, Y. Cherrah and M. E. A. Faouzi, In vivo anti-inflammatory and analgesic activities of Cistus salviifolius (L.) and Cistus monspeliensis (L.) aqueous extracts, South African J. Bot. 113 (2017) 160–163; https://doi.org/10.1016/j.sajb.2017.08.015Search in Google Scholar

20S. Sood, B. Arora, S. Bansal, A. Muthuraman, N. S. Gill, R. Arora, M. Bali and P. D. Sharma, Anti-oxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract, Inflammo pharmacology 17 (2009) 267–274; https://doi.org/10.1007/S10787-009-0015-YSearch in Google Scholar

21A. El Hamsas El Youbi, L. El Mansouri, S. Boukhira, A. Daoudi and D. Bousta, In vivo anti-inflammatory and analgesic effects of aqueous extract of Cistus ladanifer L. from Morocco, Am. J. Ther. 23 (2016) e1554–e1559; https://doi.org/10.1097/MJT.0000000000000419Search in Google Scholar

22B. Bueno-Silva, A. Marsola, M. Ikegaki, S. M. Alencar and P. L. Rosalen, The effect of seasons on Brazilian red propolis and its botanical source: chemical composition and antibacterial activity, Nat. Prod. Res. 31 (2017) 1318–1324; https://doi.org/10.1080/14786419.2016.1239088Search in Google Scholar

23S. Ait Lahcen, L. El Hattabi, R. Benkaddour, N. Chahboun, M. Ghanmi, B. Satrani, M. Tabyaoui and A. Zarrouk, Chemical composition, antioxidant, antimicrobial and antifungal activity of Moroccan Cistus creticus leaves, Chem. Data Collect. 26 (2020) Article ID 100346; https://doi.org/10.1016/j.cdc.2020.100346Search in Google Scholar

24S. Haida, K. Bakkouche, A. R. Kribii and A. Kribii, Chemical composition of essential oil, phenolic compounds content, and antioxidant activity of Cistus monspeliensis from Northern Morocco, Biochem. Res. Int. 2021 (2021) Article ID 6669877 (13 pages); https://doi.org/10.1155/2021/6669877Search in Google Scholar

25M. Di Rosa, J. P. Giroud and D. A. Willoughby, Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine, J. Pathol. 104 (1971) 15–29; https://doi.org/10.1002/PATH.1711040103Search in Google Scholar

26S. O. Okpo, F. Fatokun and O. O. Adeyemi, Analgesic and anti-inflammatory activity of Crinum glaucum aqueous extract, J. Ethnopharmacol. 78(2–3) (2001) 207–211; https://doi.org/10.1016/S0378-8741(01)00318-XSearch in Google Scholar

27V. García-Mediavilla, I. Crespo, P. S. Collado, A. Esteller, S. Sánchez-Campos, M. J. Tuñón and J. González-Gallego, The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang liver cells, Eur. J. Pharmacol. 557 (2007) 221–229; https://doi.org/10.1016/j.ejphar.2006.11.014Search in Google Scholar

28E. dine T. Bouhlali, J. El Hilaly, J. Ennassir, M. Benlyas, C. Alem, M.-Y. Amarouch and Y. Filali-Zegzouti, Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties, J. King Saud Univ. – Sci. 30(4) (2018) 519–526; https://doi.org/10.1016/j.jksus.2017.08.011Search in Google Scholar

29M. Ali, T. Homann, J. Kreisel, M. Khalil, R. Puhlmann, H. P. Kruse and H. Rawel, Characterization and modeling of the interactions between coffee storage proteins and phenolic compounds, J. Agric. Food Chem. 60 (2012) 11601–11608; https://doi.org/10.1021/jf303372aSearch in Google Scholar

30H. Ojha, K. Mishra, M. I. Hassan and N. K. Chaudhury, Spectroscopic and isothermal titration calorimetry studies of binding interaction of ferulic acid with bovine serum albumin, Thermochim. Acta 548 (2012) 56–64; https://doi.org/10.1016/j.tca.2012.08.016Search in Google Scholar

31A. I. de Andrés, M. P. Gómez-Serranillos, I. Iglesias and A. M. Villar, Effects of extract of Cistus populifolius L. on the central nervous system, Phyther. Res. 13 (1999) 575–579; https://doi.org/10.1002/(SICI)1099-1573(199911)13:7<575::AID-PTR506>3.0.CO;2-WSearch in Google Scholar

32M. Ark, O. Üstün and E. Yeşilada, Analgesic activity of Cistus laurifolius in mice, Pharm. Biol. 42 (2004) 176–178; https://doi.org/10.1080/13880200490512250Search in Google Scholar

33E. Küpeli and E. Yesilada, Flavonoids with anti-inflammatory and antinociceptive activity from Cistus laurifolius L. leaves through bioassay-guided procedures, J. Ethnopharmacol. 112 (2007) 524–530; https://doi.org/10.1016/j.jep.2007.04.011Search in Google Scholar

34O. Tahiri, D. Atmani-Kilani, S. Sanchez-Fidalgo, M. Aparicio-Soto, C. Alarcón-de-la-Lastra, E. Barrajón-Catalán, V. Micol and D. Atmani, The flavonol-enriched Cistus albidus chloroform extract possesses in vivo anti-inflammatory and anti-nociceptive activity, J. Ethnopharmacol. 209 (2017) 210–218; https://doi.org/10.1016/j.jep.2017.07.012Search in Google Scholar

35E. Barrajõn-Catalán, S. Fernández-Arroyo, C. Roldán, E. Guillén, D. Saura, A. Segura-Carretero and V. Micol, A systematic study of the polyphenolic composition of aqueous extracts deriving from several Cistus genus species: Evolutionary relationship, Phytochem. Anal. 22 (2011) 303–312; https://doi.org/10.1002/pca.1281Search in Google Scholar

36N. Latief, S. Anand, M. C. Lingaraju, V. Balaganur, N. N. Pathak, J. Kalra, D. Kumar, B. K. Bha-doria and S. K. Tandan, Effect of trimeric myricetin rhamnoside (TMR) in carrageenan-induced inflammation and caecal ligation and puncture-induced lung oxidative stress in mice, Phytother. Res. 29(11) (2015) 1798–1805; https://doi.org/10.1002/ptr.5446Search in Google Scholar

37F. C. Meotti, A. P. Luiz, M. G. Pizzolatti, C. A. L. Kassuya, J. B. Calixto and A. R. S. Santos, Analysis of the antinociceptive effect of the flavonoid myricitrin: Evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways, J. Pharmacol. Exp. Ther. 316 (2006) 789–796; https://doi.org/10.1124/jpet.105.092825Search in Google Scholar