Number (%) | Oxidative stress marker | Odds ratio (95% CI) Sex, smoking, and alcohol consumption were adjusted for odds ratio, GSH = reduced glutathione, GPx = glutathione peroxidase, SOD, superoxide dismutase, CAT = catalase, and MDA = malondialdehyde. | |
---|---|---|---|
Reference | 1.0 | ||
Wild-type | GSH | 0.996 (0.997-1.02) | 0.66 |
n= 984 (71.3) | CAT | 0.73 (0.28-1.91) | 0.52 |
• Heterozygous | SOD | 0.58 (0.33-1.03) | 0.06 |
n= 351 (25.4) | GPx | ||
MDA | 1.24 (0.79-1.97) | 0.35 | |
• Variant | GSH | 1.00 (0.96-1.05) | 0.94 |
n = 45 (3.3) | CAT | 6.49 (0.86-48.8) | 0.07 |
SOD | 0.38 (0.09-1.54) | 0.17 | |
GPx | 3.33 (0.65-17.15) | 0.15 | |
MDA | 0.81 (0.27-2.46) | 0.72 | |
Reference | 1.0 | ||
• Wild-type | GSH | 0.997 (0.98-1.02) | 0.73 |
n= 979 (70.9) | CAT | 0.60 (0.23-1.56) | 0.29 |
• Heterozygous | SOD | 0.59 (0.33-1.05) | 0.07 |
n= 353 (25.6) | GPx | ||
MDA | 1.27 (0.80-2.01) | 0.31 | |
• Variant | GSH | 1.01 (0.97-1.05) | 0.61 |
n = 48 (3.5) | CAT | ||
SOD | 0.19 (0.05ndash;0.77) | 0.20 | |
GPx | 2.34 (048-114) | 0.24 | |
MDA | 1.21 (043-3.52) | 0.71 | |
Reference | 1.0 | ||
• Wild-type | GSH | 0.99 (0.97-1.01) | 0.26 |
n= 839 (60.8) | CAT | 0.68 (0.28-1.65) | 0.40 |
• Heterozygous | SOD | 0.64 (0.38-1.09) | 0.10 |
n= 464 (33.6) | GPx | 1.79 (0.96-3.33) | 0.07 |
MDA | 0.99 (0.79-1.97) | 0.97 | |
• Variant | GSH | 0.99 (0.95-1.03) | 0.58 |
n = 77 (5.6) | CAT | 2.32 (042-13.0) | 0.34 |
SOD | 0.78 (0.26-2.28) | 0.64 | |
GPx | 1.92 (0.53 −6.90) | 0.32 | |
MDA | 1.08 (045-2.59) | 0.86 | |
Reference | 1.0 | ||
• Wild-type | GSH | 1.02 (0.998-1.04) | 0.08 |
n=438 (31.7) | CAT | 1.45 (0.57-3.66) | 0.44 |
• Heterozygous | SOD | 1.31 (0.75-2.28) | 0.35 |
n=690 (50.0) | GPx | 0.90 (0.47-1.72) | 0.74 |
MDA | 0.89 (0.56-1.40) | 0.61 | |
• Variant | GSH | 1.02 (0.99-1.04) | 0.19 |
n=252 (18.3) | CAT | 0.75 (0.22-2.53) | 0.65 |
SOD | 1.09 (0.53-2.25) | 0.81 | |
GPx | 1.98 (0.84-4.64) | 0.12 | |
MDA | 1.15 (0.64-2.05) | 0.65 | |
Cholesterol<200 mg/dL | Reference | 1.0 | |
n= 320 (23.2) | |||
Cholesterol≥200 mg/dL | GSH | 1.01 (0.99-1.03) | 0.42 |
n= 1060 (76.8) | CAT | 0.68 (0.26-1.79) | 0.43 |
SOD | 0.85 (0.48-1.50) | 0.57 | |
GPx | 0.59 (0.30-1.17) | 0.13 | |
MDA | |||
Triglyceride < 150 mg/dL | Reference | 1.0 | |
n= 874 (63.3) | |||
Triglyceride | GSH | 0.99 (0.98-1.01) | 0.56 |
≥200 mg/dL | CAT | 0.42 (0.18-1.01) | 0.05 |
n= 506 (36.7) | SOD | 1.13 (0.68-1.89) | 0.64 |
GPx | 1.05 (0.57-1.93) | 0.87 | |
MDA |
Characteristics | Lipid profile | ||||
---|---|---|---|---|---|
Normolipidemia (n = 236) | Hypercholesterolemia (n = 638) | Hypertriglyceridemia (n = 84) | Combined hyperlipidemia (n = 422) | ||
Age (years) Data = mean ± SD or n (%) | 51.6±4.7 | 51.0±44 | 51.9±4.8 | 51.9±4.3 | 0.08 |
Weight (kg) Data = mean ± SD or n (%) | 67.1 ±11.5 | 64.5 ± 10.8 | 69.3 ± 10.9 | 69.6 ±10.6 | 0.46 |
Height (cm) Data = mean ± SD or n (%) | 164.4 ±8.2 | 163.3 ±7.6 | 164.3 ±7.7 | 164.8 ±7.5 | 0.16 |
BMI (kg/m2) Data = mean ± SD or n (%) | 24.8 ±3.48 | 24.1 ±3.23 | 25.6±3.38 hypercholesterolemia or hypertriglyceridemia compare with normolipidemia | 25.6 ±3.41 | <.001 hypercholesterolemia or hypertriglyceridemia compare with normolipidemia |
Cholesterol (mg/dL) Data = mean ± SD or n (%) | 179.0 ±19.12 | 242.6 ±28.93 hypercholesterolemia or hypertriglyceridemia compare with normolipidemia | 180.1 ±18.29 | 253.1 ±35.80 combined hyperlipidemia compared with normolipidemia | <.001 hypercholesterolemia or hypertriglyceridemia compare with normolipidemia combined hyperlipidemia compared with normolipidemia |
Triglyceride (mg/dL) Data = mean ± SD or n (%) | 93.3 ±32.40 | 98.9 ±30.08 | 224.5 ± 95.70 hypercholesterolemia or hypertriglyceridemia compare with normolipidemia | 233.7 ±105.32 combined hyperlipidemia compared with normolipidemia | <0.001 hypercholesterolemia or hypertriglyceridemia compare with normolipidemia combined hyperlipidemia compared with normolipidemia |
LDL-C (mg/dL) Data = mean ± SD or n (%) | 113.9±1547 | 164.6 ± 30.13 hypercholesterolemia or hypertriglyceridemia compare with normolipidemia | 95.8± 19.12 | 159.4 ±3642 combined hyperlipidemia compared with normolipidemia | <.001 hypercholesterolemia or hypertriglyceridemia compare with normolipidemia combined hyperlipidemia compared with normolipidemia |
HDL-C (mg/dL) Data = mean ± SD or n (%) | 50.9 ±10.31 | 56.6±11.56 hypercholesterolemia or hypertriglyceridemia compare with normolipidemia | 43.2 ±9.93 | 47.3 ±9.71 | <0.001 hypercholesterolemia or hypertriglyceridemia compare with normolipidemia |
No. of c1c1 (WT) | 175/176 (≈74) | 450/453 (≈71) | 54/55 (=65) | 300/300 (71) | <0.001 significant difference between group of lipid profiles |
No.of c1c2 (Het) | 50/50 (21) | 167/165 (=26) | 26/26 (31) | 110/110 (26) | 0.20,0.25 |
No.of c2c2 (Var) | 11/10 (≈4) | 21/20 (=3) | 4/3 (=4) | 12/12 (3) | 0.39,0.29 |
No. of DD (WT) | 148 (63) | 380 (60) | 48 (57) | 263 (62) | <0.001 significant difference between group of lipid profiles |
No. of DC (Het) | 74 (31) | 224 (35) | 30 (36) | 136 (32) | 0.07 |
No. of CC (Var) | 14 (6) | 34 (5) | 6 (7) | 23 (6) | 0.50 |
| |||||
No. of CC (WT) | 71 (30) | 210 (33) | 30 (36) | 127 (30) | 0.10 |
No of CT (Het) | 116 (49) | 318 (50) | 41 (48) | 215 (51) | <0.001 significant difference between group of lipid profiles |
No. of TT (Var) | 49 (21) | 110 (17) | 13 (16) | 80 (19) | 0.41 |
Sex | |||||
Male | 170 (72) | 419 (66) | 63 (75) | 331 (78) | <0.001 significant difference between group of lipid profiles |
Female | 66 (28) | 219 (34) | 21 (25) | 91 (22) | 0.21 |
Smoking | 33 (14) | 64 (10) | 11 (13) | 82 (19) | <0.001 significant difference between group of lipid profiles |
Nonsmoking | 203 (86) | 574 (90) | 73 (87) | 340 (81) | 0.001 |
Alcohol drinking | 115 (49) | 304 (48) | 43 (51) | 248 (59) | <0.001 significant difference between group of lipid profiles |
Alcohol abstinence | 121 (51) | 334 (52) | 41 (49) | 174 (41) | 0.02* |