Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe²⁺ chelating activity

A. Paboón, J. Carmona, L. C. Burgos and S. Blair, Oxidative stress in patients with non-complicated malaria, Clin. Biochem. 36 (2003) 71-78; DOI: 10.1016/S0009-9120(02)00423-X.10.1016/S0009-9120(02)00423-XSearch in Google Scholar

D. V. Ratnam, D. D. Ankola, V. Bhardwaj, D. K. Sahana and M. N. V. Ravi Kumar, Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective, J. Control. Rel. 113 (2006) 189-207; DOI: 10.1016/j.jconrel.2006.04.015.10.1016/j.jconrel.2006.04.015Search in Google Scholar

O. M. Akanbi, A. B. Odaibo, R. Olatoregun and A. B. Ademowo, Role of malaria induced oxidative stress on anaemia in pregnancy, Asian Pac. J. Trop. Med. 3 (2010) 211-214.10.1016/S1995-7645(10)60011-9Search in Google Scholar

L. M. Veggi, L. Pretto, E. J. Ochoa, V. A. Catania, M. G. Luquita, D. R. Taborda, E. J. Sánchez Pozzi, S. Ikushiro, M. D. Coleman, M. G. Roma and A. D. Mottino, Dapsone induces oxidative stress and impairs antioxidant defenses in rat liver, Life Sci. 83 (2008) 155-163; DOI: 10.1016/j.lfs.2008.05.016.10.1016/j.lfs.2008.05.016Search in Google Scholar

N. Vale, R. Moreira and P. Gomes, Primaquine revisited six decades after its discovery, Eur. J. Med. Chem. 44 (2009) 937-953; DOI: 10.1016/j.ejmech.2008.08.011.10.1016/j.ejmech.2008.08.011Search in Google Scholar

M. Jain, S. Vangapandu, S. Sachdeva and R. Jain, Synthesis and blood-schizontocidal antimalarial activities of 2-substituted/2,5-disubstituted-8-quinolinamines and some of their amino acid conjugates, Bioorg. Med. Chem. 12 (2004) 1003-1010; DOI: 10.1016/j.bmc.2003.12.029.10.1016/j.bmc.2003.12.029Search in Google Scholar

M. Šimunović, I. Perković, B. Zorc, K. Ester, M. Kralj, D. Hadjipavlou-Litina and E. Pontiki, Urea and carbamate derivatives of primaquine: Synthesis, cytostatic and antioxidant activities, Bioorg. Med. Chem. 17 (2009) 5605-5613; DOI: 10.1016/j.bmc.2009.06.030.10.1016/j.bmc.2009.06.030Search in Google Scholar

M. Zovko Končić, Z. Rajić, N. Petrić and B. Zorc, Antioxidant activity of NSAID hydroxamic acids, Acta Pharm. 59 (2009) 235-242; DOI: 10.2478/v10007-009-0017-8.10.2478/v10007-009-0017-8Search in Google Scholar

G. F. Mabeza, M. Loyevsky, V. R. Gordeuk and G. Weiss, Iron chelation therapy for malaria: A review, Pharmacol. Ther. 81 (1999) 53-75.10.1016/S0163-7258(98)00037-0Search in Google Scholar

M. J. Thun, S. J. Henley and C. Patrono, Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues, J. Natl. Cancer Inst. 94 (2002) 252-266; DOI: 10.1093/jnci/94.4.267.10.1093/jnci/94.4.26711854388Search in Google Scholar

B. Zorc, S. Antolić and I. Butula, Macromolecular prodrugs. I. Synthesis of some non-steroidal anti-inflammatory drug esters, Acta Pharm. 43 (1993) 127-133.Search in Google Scholar

Z. Rajić, D. Hadjipavlou-Litina, E. Pontiki, M. Kralj, L. Šuman and B. Zorc, The novel ketoprofen amides - Synthesis and biological evaluation as antioxidants, lipoxygenase inhibitors and cytostatic agents, Chem. Biol. Drug Des. 75 (2010) 641-652; DOI: 10.1111/j.1747-0285.2010. 00963.x.Search in Google Scholar

G. C. Yen and H. Y. Chen, Antioxidant activity of various tea extracts in relation to their antimutagenicity, J. Agric. Food Chem. 43 (1995) 27-32; DOI: 10.1021/jf00049a007.10.1021/jf00049a007Search in Google Scholar

R. Amarowicz, R. B. Pegg, P. Rahimi-Moghaddam, B. Barl and J. A. Weil, Free-radical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies, Food Chem. 84 (2004) 551-562; DOI: 10.1016/S0308-8146(03)00278-4.10.1016/S0308-8146(03)00278-4Search in Google Scholar

M. S. Al-Saikhan, L. R. Howard and J. C. Miller, Jr., Antioxidant activity and total phenolics in different genotypes of potato (Solanum tuberosum, L.), J. Food Sci. 60 (1995) 341-343.10.1111/j.1365-2621.1995.tb05668.xSearch in Google Scholar

E. A. Decker and B. Welch, Role of ferritin as lipid oxidation catalyst in muscle food, J. Agric. Food Chem. 38 (1990) 674-677; DOI: 10.1021/jf00093a018.10.1021/jf00093a018Search in Google Scholar