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Screening strategy modification based on personalized breast cancer risk stratification and its implementation in the national guidelines – pilot study

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Breast cancer risk categories for Slovenian women.

Breast cancer risk category
Low risk (%) Population risk (%) Moderately increased risk (%) High risk (%)
Lifetime risk between ages 20 and 39 - <16 16 and higher >30
10-year risk between ages 40 and 49 - <2.0 2.0 to 6.5 >6.5
10-year risk between ages 50 and 59 <1.3 1.3 to<4.0 4.0 to 6.5 >6.5
10-year risk from age 60+ <1.3 1.3 to<5.5 5.5 to 6.5 >6.5

Characteristics of the studied women according to breast cancer risk factors.

Number of women Percent (%)
Age groups
20-39 years 87 44.2
40-49 years 104 52.8
50-59 years 6 3.0
Family history
positive 62 31.5
negative 135 68.5
Age at menarche
<11 years 7 3.6
11-12 years 57 28.9
13-14 years 108 54.8
>15 years 25 12.7
Age at first full-term birth
<25 years 81 41.1
25-29 years 54 27.4
>30 years 31 15.7
nulliparous 31 15.7

The summary of criteria for the higher risk women category and advised breast cancer screening tests according to current Rules on Carrying Out Preventive Health Care at the Primary Level (5).

Criteria for higher breast cancer risk category (at least one of the following) Screening tests at a Breast Unit for the higher breast cancer risk category (after the age of 40)
First full-term birth >30 years
Clinical breast examination (every 12-24 months) and Mammography and/or ultrasound examination of the breast or No screening is performed according to clinician decision
At least one relative (mother, sister, daughter) with breast cancer
Personal history of breast disease that increases breast cancer risk
Personal history of breast cancer in the past

Comparison of anticipated mammographic screening and screening foreseen in the new Slovenian guidelines by breast cancer risk categories and age groups.

Anticipated mammographic screening (number of women)
Mammographic screening according to the new Slovenian guidelines (number of women)
Breast cancer risk category

Risk category was determined by S-IBIS calculation, and division into risk groups was performed as proposed in Table 3.

Population risk Moderately increased risk Population risk Moderately increased risk
Ages between 20 and 39 5 4 0 0
Ages between 40 and 49 43 27 0 34
Ages between 50 and 55 1 - 6 -
All ages 49 31 6 34

Comparison of anticipated ultrasound screening for breast cancer prevention and screening foreseen in the new Slovenian guidelines by breast cancer risk categories and age groups.

Anticipated ultrasound screening (number of women)
Ultrasound screening according to the new Slovenian guidelines
Breast cancer risk category

Risk category was determined by S-IBIS calculation, and division into risk groups was performed as proposed in Table 3.

Population risk Moderately increased risk Population risk Moderately increased risk
Ages between 20 and 39 7 3 According to the new guidelines ultrasound screening is recommended only upon referral from a radiologist
Ages between 40 and 49 14 9
Ages between 50 and 55 0 -
All ages 21 12
eISSN:
1854-2476
Lingua:
Inglese
Frequenza di pubblicazione:
4 volte all'anno
Argomenti della rivista:
Medicine, Clinical Medicine, Hygiene and Environmental Medicine