Diacylglycerol kinase is downregulated in the Drosophila Seizure Mutant during Spaceflight

Avila-Flores A, Santos T, Rincón E, Mérida I (2005) Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid. Journal of Biological Chemistry 280(11): 10091–9. doi: 10.1074/jbc.M412296200. Avila-FloresA SantosT RincónE MéridaI 2005 Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid Journal of Biological Chemistry 280 11 10091 9 10.1074/jbc.M412296200 Open DOISearch in Google Scholar

Beheshti A, Shirazi-Fard Y, Choi S, Berrios D, Gebre SG, Galazka JM, Costes SV (2019) Exploring the effects of spaceflight on mouse physiology using the open access NASA GeneLab platform. Journal of Visualized Experiments 13: 143. doi: 10.3791/58447. BeheshtiA Shirazi-FardY ChoiS BerriosD GebreSG GalazkaJM CostesSV 2019 Exploring the effects of spaceflight on mouse physiology using the open access NASA GeneLab platform Journal of Visualized Experiments 13 143 10.3791/58447 Open DOISearch in Google Scholar

Chen L, Liao F, Wu J, Wang Z, Jiang Z, Zhang C, Luo P, Ma L, Gong Q, Wang Y, Wang Q, Luo M, Yang Z, Han S, Shi C (2021) Acceleration of ageing via disturbing mTOR-regulated proteostasis by a new ageing-associated gene PC4. Aging Cell 20: e13370. doi.org/10.1111/acel.13370. ChenL LiaoF WuJ WangZ JiangZ ZhangC LuoP MaL GongQ WangY WangQ LuoM YangZ HanS ShiC 2021 Acceleration of ageing via disturbing mTOR-regulated proteostasis by a new ageing-associated gene PC4 Aging Cell 20 e13370 doi.org/10.1111/acel.13370. Search in Google Scholar

Hill AS, Jain P, Folan NE, Ben-Shahar Y (2019) The drosophila erg channel seizure plays a role in the neuronal homeostatic stress response. PLoS genetics 15(8): e1008288. doi: 10.1371/journal.pgen.1008288. HillAS JainP FolanNE Ben-ShaharY 2019 The drosophila erg channel seizure plays a role in the neuronal homeostatic stress response PLoS genetics 15 8 e1008288 10.1371/journal.pgen.1008288 Open DOISearch in Google Scholar

Kandarpa K, Schneider V, Ganapathy E (2019) Human health during space travel: An overview. Neurology India 67(Supplement): S176–S181. doi: 10.4103/0028-3886.259123. KandarpaK SchneiderV GanapathyE 2019 Human health during space travel: An overview Neurology India 67 Supplement S176 S181 10.4103/0028-3886.259123 Open DOISearch in Google Scholar

Lin YH, Chen YC, Kao TY, Lin YC, Hsu TE, Wu YC, Ja WW, Brummel TJ, Kapahi P, Yuh CH, Yu LK, Lin ZH, You RJ, Jhong YT, Wang HD (2014) Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans. Aging Cell 13(4): 755–64. doi: 10.1111/acel.12232. LinYH ChenYC KaoTY LinYC HsuTE WuYC JaWW BrummelTJ KapahiP YuhCH YuLK LinZH YouRJ JhongYT WangHD 2014 Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans Aging Cell 13 4 755 64 10.1111/acel.12232 Open DOISearch in Google Scholar

Liu Z, Huang X (2013) Lipid metabolism in drosophila: Development and disease. Acta Biochimica et Biophysica Sinica 45(1): 44–50. doi: 10.1093/abbs/gms105. LiuZ HuangX 2013 Lipid metabolism in drosophila: Development and disease Acta Biochimica et Biophysica Sinica 45 1 44 50 10.1093/abbs/gms105 Open DOISearch in Google Scholar

López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153(6): 1194–217. doi: 10.1016/j.cell.2013.05.039. López-OtínC BlascoMA PartridgeL SerranoM KroemerG 2013 The hallmarks of aging Cell 153 6 1194 217 10.1016/j.cell.2013.05.039 Open DOISearch in Google Scholar

Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette F, Topisirovic I, Hulea L (2019) MTOR as a central regulator of lifespan and aging. F1000Research 8: F1000 Faculty Rev-998. doi: 10.12688/f1000research.17196.1. PapadopoliD BoulayK KazakL PollakM MalletteF TopisirovicI HuleaL 2019 MTOR as a central regulator of lifespan and aging F1000Research 8 F1000 Faculty Rev-998. 10.12688/f1000research.17196.1 Open DOISearch in Google Scholar

Stein TP (2002) Space flight and oxidative stress. Nutrition 18(10): 867–71. doi: 10.1016/s0899-9007(02)00938-3. SteinTP 2002 Space flight and oxidative stress Nutrition 18 10 867 71 10.1016/s0899-9007(02)00938-3 Open DOISearch in Google Scholar

Tavassoli M (1986) Medical problems of space flight. The American Journal of Medicine 81(5): 850–4. doi: 10.1016/0002-9343(86)90357-8. TavassoliM 1986 Medical problems of space flight The American Journal of Medicine 81 5 850 4 10.1016/0002-9343(86)90357-8 Open DOISearch in Google Scholar

Tolwinski NS (2017) Introduction: Drosophila-A model system for developmental biology. Journal of Developmental Biology 5(3): 9. doi: 10.3390/jdb5030009. TolwinskiNS 2017 Introduction: Drosophila-A model system for developmental biology Journal of Developmental Biology 5 3 9 10.3390/jdb5030009 Open DOISearch in Google Scholar

Torres-Ayuso P, Tello-Lafoz M, Mérida I, Ávila-Flores A (2015) Diacylglycerol kinase-ζ regulates mtorc1 and lipogenic metabolism in cancer cells through SREBP-1. Oncogenesis 4(8): e164. doi: 10.1038/oncsis.2015.22. Torres-AyusoP Tello-LafozM MéridaI Ávila-FloresA 2015 Diacylglycerol kinase-ζ regulates mtorc1 and lipogenic metabolism in cancer cells through SREBP-1 Oncogenesis 4 8 e164 10.1038/oncsis.2015.22 Open DOISearch in Google Scholar

Verkinos J, Schneider VS (2010) Space, gravity and the physiology of aging: Parallel or convergent disciplines? A mini-review. Gerontology 56(2): 157–66. doi: 10.1159/000252852. VerkinosJ SchneiderVS 2010 Space, gravity and the physiology of aging: Parallel or convergent disciplines? A mini-review Gerontology 56 2 157 66 10.1159/000252852 Open DOISearch in Google Scholar

Walls S, Diop S, Birse R, Elmen L, Gan Z, Kalvakuri S, Pineda S, Reddy C, Taylor E, Trinh B, Vogler G, Zarndt R, McCulloch A, Lee P, Bhattacharya S, Bodmer R, Ocorr K (2020) Prolonged exposure to microgravity reduces cardiac contractility and initiates remodeling in Drosophila. Cell Reports 33(10): 108445. doi: 10.1016/j.celrep.2020.108445. WallsS DiopS BirseR ElmenL GanZ KalvakuriS PinedaS ReddyC TaylorE TrinhB VoglerG ZarndtR McCullochA LeeP BhattacharyaS BodmerR OcorrK 2020 Prolonged exposure to microgravity reduces cardiac contractility and initiates remodeling in Drosophila Cell Reports 33 10 108445 10.1016/j.celrep.2020.108445 Open DOISearch in Google Scholar