Optimization of electrode position and electric pulse amplitude in electrochemotherapy

Mir LM, Gehl J, Sersa G, et al. Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the Cliniporator (TM) by means of invasive or non-invasive electrodes. Eur J Cancer Suppl 2006; 4: 14-25.10.1016/j.ejcsup.2006.08.003Search in Google Scholar

Snoj M, Rudolf Z, Cemazar M, Jancar B, Sersa G. Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy. AntiCancer Drugs 2005; 16: 345-8.10.1097/00001813-200503000-00015Search in Google Scholar

Sersa G, Cemazar M, Miklavcic D, Rudolf Z. Electrochemotherapy of tumours. Radiol Oncol 2006; 40: 163-74.Search in Google Scholar

Miklavcic D, Beravs K, Semrov D, Cemazar M, Demsar F, Sersa G. The importance of electric field distribution for effective in vivo electroporation of tissues. Biophys J 1998; 74: 2152-8.10.1016/S0006-3495(98)77924-XSearch in Google Scholar

Miklavcic D, Semrov D, Mekid H, Mir LM. A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochim Biophys Acta 2000; 1523: 73-83.10.1016/S0304-4165(00)00101-XSearch in Google Scholar

Miklavcic D, Corovic S, Pucihar G, Pavselj N. Importance of tumour coverage by sufficiently high local electric field for effective electrochemotherapy. Eur J Cancer Suppl 2006; 4: 45-51.10.1016/j.ejcsup.2006.08.006Search in Google Scholar

Pavselj N, Bregar Z, Cukjati D, Batiuskaite D, Mir LM, Miklavcic D. The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals. IEEE Trans Biomed Eng 2005; 52: 1373-81.10.1109/TBME.2005.851524Search in Google Scholar

Sel D, Lebar AM, Miklavcic D. Feasibility of employing model-based optimization of pulse amplitude and electrode distance for effective tumor electropermeabilization. IEEE Trans Biomed Eng 2007; 54: 773-81.10.1109/TBME.2006.889196Search in Google Scholar

Gilbert RA, Jaroszeski MJ, Heller R. Novel electrode designs for electrochemotherapy. Biochim Biophys Acta 1997; 1334: 9-14.10.1016/S0304-4165(96)00119-5Search in Google Scholar

Domenge C, Orlowski S, Luboinski B, DeBaere T, Schwaab G, Belehradek J, et al. Antitumor electrochemotherapy - New advances in the clinical protocol. Cancer 1996; 77: 956-63.10.1002/(SICI)1097-0142(19960301)77:5<956::AID-CNCR23>3.0.CO;2-1Search in Google Scholar

Heller R, Gilbert R, Jaroszeski MJ. Clinical applications of electrochemotherapy. Adv Drug Deliv Rev 1999; 35: 119-29.10.1016/S0169-409X(98)00067-2Search in Google Scholar

Gothelf A, Mir LM, Gehl J. Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation. Cancer Treat Rev 2003; 29: 371-87.10.1016/S0305-7372(03)00073-2Search in Google Scholar

Tijink BM, De Bree R, Van D, Leemans CR. How we do it: Chemo-electroporation in the head and neck for otherwise untreatable patients. Clin Otolaryngol 2006; 31: 447-51.10.1111/j.1749-4486.2006.01198.xSearch in Google Scholar

Marty M, Sersa G, Garbay JR, et al. Electrochemotherapy - An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer Suppl Nov 2006; 4: 3-13.10.1016/j.ejcsup.2006.08.002Search in Google Scholar

Sersa G. The state-of-the-art of electrochemotherapy before the ESOPE study; advantages and clinical uses. Eur J Cancer Suppl 2006; 4: 52-9.10.1016/j.ejcsup.2006.08.007Search in Google Scholar

Cukiati D, Batiuskaite D, Andre F, Miklavcic D, Mir LM. Real time electroporation control for accurate and safe in vivo non-viral gene therapy. Bioelectrochemistry 2007; 70: 501-7.10.1016/j.bioelechem.2006.11.001Search in Google Scholar

Pliquett UF, Vanbever R, Preat V, Weaver JC. Local transport regions (LTRs) in human stratum corneum due to long and short ‘high voltage’ pulses. Bioelectrochem Bioener 1998; 47: 151-61.10.1016/S0302-4598(98)00180-9Search in Google Scholar

Al Sakere B, Bernat C, Connault E, Opolon O, Rubinsky B, Davalos R, et al. Tumour ablation with irreversible electroporation. PLoS ONE 2007:11.10.1371/journal.pone.0001135Search in Google Scholar

Corovic S, Pavlin M, Miklavcic D. Analytical and numerical quantification and comparison of the local electric field in the tissue for different electrode configurations. Biomed Eng Online 2007; 6.10.1186/1475-925X-6-37Search in Google Scholar

Miklavcic D, Pavselj N, Hart FX. Electric properties of tissues. Wiley Encyclopedia of Biomedical Engineering. New York: John Wiley & Sons; 2006.10.1002/9780471740360.ebs0403Search in Google Scholar

Semrov D, Miklavcic D. Calculation of the electrical parameters in electrochemotherapy of solid tumours in mice. Comput Biol Med 1998; 28: 439-48.10.1016/S0010-4825(98)00017-1Search in Google Scholar

Holland JH. Adaptation in Natural and Artificial Systems: An Introductory Analysis with Applications to Biology, Control, and Artificial Intelligence. Cambridge: MIT Press; 1992.10.7551/mitpress/1090.001.0001Search in Google Scholar

Gehl J, Geertsen PF. Palliation of haemorrhaging and ulcerated cutaneous tumours using electrochemotherapy. Eur J Cancer Suppl 2006; 4: 35-7.10.1016/j.ejcsup.2006.07.007Search in Google Scholar

Gehl J, Sorensen TH, Nielsen K, Raskmark P, Nielsen SL, Skovsgaard T, et al. In vivo electroporation of skeletal muscle: threshold, efficacy and relation to electric field distribution. Biochim Biophys Acta 1999; 1428: 233-40.10.1016/S0304-4165(99)00094-XSearch in Google Scholar

Sersa G, Cemazar M, Semrov D, Miklavcic D. Changing electrode orientation improves the efficacy of electrochemotherapy of solid tumors in mice. Bioelectrochem Bioener 1996; 39: 61-6.10.1016/0302-4598(95)01866-2Search in Google Scholar

Sel D, Mazeres S, Teissie J, Miklavcic D. Finite-element modeling of needle electrodes in tissue from the perspective of frequent model computation. IEEE Trans Biomed Eng 2003; 50: 1221-32.10.1109/TBME.2003.81846614619992Search in Google Scholar

Zupanic A, Ribaric S, Miklavcic D. Increasing the repetition frequency of electric pulse delivery reduces unpleasant sensations that occur in electrochemotherapy. Neoplasma 2007; 54: 246-50.Search in Google Scholar

Puc M, Corovic S, Flisar K, Petkovsek M, Nastran J, Miklavcic D. Techniques of signal generation required for electropermeabilization. Survey of electropermeabilization devices. Bioelectrochemistry 2004; 64: 113-24.10.1016/j.bioelechem.2004.04.00115296784Search in Google Scholar