<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objectives:</bold> The goal of the study was to investigate the correlations between the interleukin-6 IL-6 -174 G/C and IL-6 -572 G/C gene polymorphisms and sepsis risk and severity in adult ICU patients.<bold>Materials and Methods:</bold> We prospectively assessed 107 septic patients and divided them into two subgroups: organ dysfunction-free sepsis subgroup S (n=60) and septic shock subgroup SS (n=47). A control group of 96 healthy individuals was included. Both patients and controls underwent IL-6 -174 G/C and -572 G/C genotyping and circulating IL-6 in the study group which were measured from samples taken in the first day of sepsis diagnosis.<bold>Results:</bold> No differences in the genotype frequencies of the two polymorphisms between study and control groups were identified. The GC genotype and C allele of IL-6 -572 G/C gene polymorphism was statistically significant more frequent in the organ dysfunction-free subgroup (p=0.01, p=0.004 respectively). No statistically significant differences for the IL-6 -174 G/C gene polymorphism were found between the two sepsis subgroups. Circulating IL-6 levels were significantly higher in the septic shock subgroup and among patients with GG genotypes of both studied polymorphisms.<bold>Conclusion:</bold> We underline the possible role of IL-6 -572 G/C as a marker of severe evolution. There is no evidence of a direct role of IL-6 -174 G/C gene polymorphism in sepsis risk and outcome. Il-6 levels are correlated with sepsis severity but not with variant genotype of investigated IL-6 gene polymorphisms.</abstract>

Objectives: The goal of the study was to investigate the correlations between the interleukin-6 IL-6 -174 G/C and IL-6 -572 G/C gene polymorphisms and sepsis risk and severity in adult ICU patients.Materials and Methods: We prospectively assessed 107 septic patients and divided them into two subgroups: organ dysfunction-free sepsis subgroup S (n=60) and septic shock subgroup SS (n=47). A control group of 96 healthy individuals was included. Both patients and controls underwent IL-6 -174 G/C and -572 G/C genotyping and circulating IL-6 in the study group which were measured from samples taken in the first day of sepsis diagnosis.Results: No differences in the genotype frequencies of the two polymorphisms between study and control groups were identified. The GC genotype and C allele of IL-6 -572 G/C gene polymorphism was statistically significant more frequent in the organ dysfunction-free subgroup (p=0.01, p=0.004 respectively). No statistically significant differences for the IL-6 -174 G/C gene polymorphism were found between the two sepsis subgroups. Circulating IL-6 levels were significantly higher in the septic shock subgroup and among patients with GG genotypes of both studied polymorphisms.Conclusion: We underline the possible role of IL-6 -572 G/C as a marker of severe evolution. There is no evidence of a direct role of IL-6 -174 G/C gene polymorphism in sepsis risk and outcome. Il-6 levels are correlated with sepsis severity but not with variant genotype of investigated IL-6 gene polymorphisms.

IL-6 gene polymorphisms and sepsis in icu adult romanian patients: a prospective study

Infectious Diseases Clinic, University of Medicine and Pharmacy Tirgu Mureș,

Department of Genetics, University of Medicine and Pharmacy, Tirgu Mureș,

Anesthesiology and Intensive Care Clinic, University of Medicine and Pharmacy Tîrgu Mureș,

Genetics Laboratory, Center for Advanced Medical and Pharmaceutical Research, University of Medicine and Pharmacy Tîrgu Mureș,

Immunology Laboratory, Center for Advanced Medical and Pharmaceutical Research, University of Medicine and Pharmacy Tîrgu Mureș,

Department of Epidemiology, University of Medicine and Pharmacy Tîrgu Mureș,

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objectives: The goal of the study was to investigate the correlations between the interleukin-6 IL-6 -174 G/C and IL-6 -572 G/C gene polymorphisms and sepsis...

IL-6 gene polymorphisms and sepsis in icu adult romanian patients: a prospective study

Publié en ligne: 18 févr. 2017

Pages: 75 - 89

Reçu: 09 nov. 2016

Accepté: 11 déc. 2016

DOI: https://doi.org/10.1515/rrlm-2016-0044

Mots clés
IL-6, sepsis, single nucleotid polymorphism

© 2017 Anca Meda Georgescu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

IL-6 gene polymorphisms and sepsis in icu adult romanian patients: a prospective study

Publié en ligne: 18 févr. 2017

Pages: 75 - 89

Reçu: 09 nov. 2016

Accepté: 11 déc. 2016

DOI: https://doi.org/10.1515/rrlm-2016-0044

Mots clésIL-6, sepsis, single nucleotid polymorphism

© 2017 Anca Meda Georgescu et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
IL-6, sepsis, single nucleotid polymorphism