<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Chronic hepatitis C viral infection is an important cause of morbidity and mortality in patients with end-stage renal disease treated with hemodialysis. Liver fibrosis represents a main determinant of liver disease prognosis and clinical management, and its assessment by liver biopsy can decide treatment allocation. Although liver biopsy is the gold standard for staging liver fibrosis, it is an invasive procedure associated with complications that are more prevalent in patients with end-stage renal disease. FibroTest represents a surrogate marker of fibrosis which evaluates the levels of apolipoprotein A1, total bilirubin, haptoglobin, gamma-glutamyltransferase and α2-macroglobulin, generating a score that indicates the level of fibrosis. Discrepancies were observed in clinical practice between FibroTest score and histopathological findings. The aim of this study was to evaluate how hemodialysis influences the level of each FibroTest parameter and the final score. The systematic literature review conducted by us suggests that hemodialysis induces a reduction in apolipoprotein A1, haptoglobin and bilirubin levels, with an increase in gamma-glutamyltransferase and alpha-2-macroglobulin levels. In conclusion, hemodialysis modifies the levels of FibroTest parameters, suggesting that it may also have an impact on the accuracy of liver fibrosis assessment in hemodialysis patients.</p></abstract>

Chronic hepatitis C viral infection is an important cause of morbidity and mortality in patients with end-stage renal disease treated with hemodialysis. Liver fibrosis represents a main determinant of liver disease prognosis and clinical management, and its assessment by liver biopsy can decide treatment allocation. Although liver biopsy is the gold standard for staging liver fibrosis, it is an invasive procedure associated with complications that are more prevalent in patients with end-stage renal disease. FibroTest represents a surrogate marker of fibrosis which evaluates the levels of apolipoprotein A1, total bilirubin, haptoglobin, gamma-glutamyltransferase and α2-macroglobulin, generating a score that indicates the level of fibrosis. Discrepancies were observed in clinical practice between FibroTest score and histopathological findings. The aim of this study was to evaluate how hemodialysis influences the level of each FibroTest parameter and the final score. The systematic literature review conducted by us suggests that hemodialysis induces a reduction in apolipoprotein A1, haptoglobin and bilirubin levels, with an increase in gamma-glutamyltransferase and alpha-2-macroglobulin levels. In conclusion, hemodialysis modifies the levels of FibroTest parameters, suggesting that it may also have an impact on the accuracy of liver fibrosis assessment in hemodialysis patients.

The influence of hemodialysis on FibroTest parameters

“Iuliu Hatieganu” University of Medicine and Pharmacy

“Prof. Dr. Octavian Fodor” Regional Institute of Gastroenterology and Hepatology

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The influence of hemodialysis on FibroTest parameters"}

Chronic hepatitis C viral infection is an important cause of morbidity and mortality in patients with end-stage renal disease treated with hemodialysis. Liver...

The influence of hemodialysis on FibroTest parameters

Publicado en línea: 04 nov 2019

Páginas: 361 - 373

Recibido: 15 jul 2019

Aceptado: 26 sept 2019

DOI: https://doi.org/10.2478/rrlm-2019-0040

Palabras clave
hemodialysis, apolipoprotein A1, bilirubin, alpha-2-macroglobulin, haptoglobin, gamma-glutamyltransferase

© 2019 Olga Hilda Orasan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The influence of hemodialysis on FibroTest parameters

Publicado en línea: 04 nov 2019

Páginas: 361 - 373

Recibido: 15 jul 2019

Aceptado: 26 sept 2019

DOI: https://doi.org/10.2478/rrlm-2019-0040

Palabras clavehemodialysis, apolipoprotein A1, bilirubin, alpha-2-macroglobulin, haptoglobin, gamma-glutamyltransferase

© 2019 Olga Hilda Orasan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
hemodialysis, apolipoprotein A1, bilirubin, alpha-2-macroglobulin, haptoglobin, gamma-glutamyltransferase