The hepatoprotective and antioxidative effect of saffron stigma alcoholic extract against vincristine sulfate induced toxicity in rats

Amin A, Hamza AA, Daoud S, Khazanehdari K, Hrout AA, Baig B, Chaiboonchoe A, Adrian TE, Zaki N, Salehi-Ashtiani K. (2016). Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In vivo, In vitro and Network Analyses. Recent Pat Anticancer Drug Discov11: 121–133.10.2174/1574892810666151102110248Search in Google Scholar

Assimopoulou AN, Sinakos Z, Papageorgiou VP. (2005). Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother Res19: 997–1000.10.1002/ptr.1749Search in Google Scholar

Ben Salem I, Boussabbeh M, Kantaoui H, Bacha H, Abid-Essefi S. (2016). Crocin, the main active saffron constituent, mitigates dichlorvos-induced oxidative stress and apoptosis in HCT-116 cells. Biomed Pharmacother82: 65–71.10.1016/j.biopha.2016.04.063Search in Google Scholar

Benzie IF, Strain JJ. (1996). The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem239: 70–76.10.1006/abio.1996.0292Search in Google Scholar

Berger F, Hensel A, Nieber K. (2011). Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. Neuroscience180: 238–247.10.1016/j.neuroscience.2011.02.037Search in Google Scholar

Blajeski AL, Phan VA, Kottke TJ, Kaufmann SH. (2002). G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. J Clin Invest110: 91–99.10.1172/JCI200213275Search in Google Scholar

Das I, Das S, Saha T. (2010). Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: A histopathological study. Acta Histochem112: 317–327.10.1016/j.acthis.2009.02.003Search in Google Scholar

Das I, Chakrabarty RN, Das S. (2004). Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice. Asian Pac J Cancer Prev5: 70–76.Search in Google Scholar

El-Beshbishy HA, Hassan MH, Aly HA, Doghish AS, Alghaithy AA. (2012). Crocin “saffron” protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes. Ecotoxicol Environ Saf83: 47–54.10.1016/j.ecoenv.2012.06.003Search in Google Scholar

el Saghir NS, Hawkins KA. (1984). Hepatotoxicity following vincristine therapy. Cancer54: 2006–2008.10.1002/1097-0142(19841101)54:9<2006::AID-CNCR2820540937>3.0.CO;2-FSearch in Google Scholar

Fossati P, Ponti M, Prencipe L, Tarenghi G. (1989). One-step protocol for assays of total and direct bilirubin with stable combined reagents. Clin Chem35: 173–176.10.1093/clinchem/35.1.173Search in Google Scholar

Geyp M, Ireland CM, Pittman SM. (1996). Resistance to apoptotic cell death in a drug resistant T cell leukaemia cell line. Leukemia10: 447–455.Search in Google Scholar

Ghaffari S, Hatami H, Dehghan G. (2015). Saffron ethanolic extract attenuates oxidative stress, spatial learning, and memory impairments induced by local injection of ethidium bromide. Res Pharm Sci10: 222–232.Search in Google Scholar

Gidding CE, Kellie SJ, Kamps WA, de Graaf SS. (1999). Vincristine revisited. Crit Rev Oncol Hematol29: 267–287.10.1016/S1040-8428(98)00023-7Search in Google Scholar

Harrington M. (2011). Saffron offers protection from liver cancer. Lab Animal40: 289.10.1038/laban1011-289aSearch in Google Scholar

He SY, Qian ZY, Tang FT, Wen N, Xu GL, Sheng L. (2005). Effect of crocin on experimental atherosclerosis in quails and its mechanisms. Life Sci77: 907–921.10.1016/j.lfs.2005.02.006Search in Google Scholar

Hosseini A, Mousavi SH, Ghanbari A, Homaee Shandiz F, Raziee HR, Pezeshki Rad M, Mousavi SH. (2015). Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial. Avicenna J Phytomed5: 434–440.Search in Google Scholar

Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. (2005). Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci8: 387–393.Search in Google Scholar

Chahine N, Makhlouf H, Duca L, Martiny L, Chahine R. (2014). Cardioprotective effect of saffron extracts against acute doxorubicin toxicity in isolated rabbit hearts submitted to ischemia-reperfusion injury. Z Naturforsch C J Biosci69: 459–470.10.5560/znc.2014-0124Search in Google Scholar

Jordan MA, Thrower D, Wilson L. (1992). Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis. J Cell Sci102 ( Pt 3): 401–416.10.1242/jcs.102.3.401Search in Google Scholar

Kamalipour M, Akhondzadeh S. (2011). Cardiovascular effects of saffron: an evidence-based review. J Tehran Heart Cent6: 59–61.Search in Google Scholar

Koul A, Abraham SK. (2017). Intake of saffron reduces gamma-radiation-induced genotoxicity and oxidative stress in mice. Toxicol Mech Methods27: 428–434.10.1080/15376516.2017.1307476Search in Google Scholar

Kumar A, Patil D, Rajamohanan PR, Ahmad A. (2013). Isolation, purification and characterization of vinblastine and vincristine from endophytic fungus Fusarium oxysporum isolated from Catharanthus roseus. PloS One8: e71805.10.1371/journal.pone.0071805Search in Google Scholar

Mahmoudzadeh L, Najafi H, Ashtiyani SC, Yarijani ZM. (2017). Anti-inflammatory and protective effects of saffron extract in ischaemia/reperfusion-induced acute kidney injury. Nephrology22: 748–754.10.1111/nep.12849Search in Google Scholar

Martins DB, Lopes STA, Mazzanti CM, Spanevello R, Schmatz R, Corrêa M, Stefanello N, Schetinger MR, Morsch V, Veiga APM. (2011). Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate. Arq Bras Med Vet Zootec63: 107–113.10.1590/S0102-09352011000100017Search in Google Scholar

Mashmoul M, Azlan A, Khaza’ai H, Yusof BN, Noor SM. (2013). Saffron: A Natural Potent Antioxidant as a Promising Anti-Obesity Drug. Antioxidants2: 293–308.10.3390/antiox2040293Search in Google Scholar

Mashmoul M, Azlan A, Mohtarrudin N, Mohd Yusof BN, Khaza’ai H, Khoo HE, Farzadnia M, Boroushaki MT. (2016). Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats. BMC Complement Altern Med16: 401.10.1186/s12906-016-1381-9Search in Google Scholar

Nair SC, Kurumboor SK, Hasegawa JH. (1995). Saffron chemoprevention in biology and medicine: a review. Cancer Biother10: 257–264.10.1089/cbr.1995.10.257Search in Google Scholar

Nevalainen TJ. (1975). Cytotoxicity of vinblastine and vincristine to pancreatic acinar cells. Virchows Arch B Cell Pathol18: 119–127.10.1007/BF02889240Search in Google Scholar

Ogunc Y, Demirel M, Yakar A, Incesu Z. (2017). Vincristine and varepsilon-viniferine-loaded PLGA-b-PEG nanoparticles: pharmaceutical characteristics, cellular uptake and cytotoxicity. J Microencapsul34: 38–46.10.1080/02652048.2017.1282549Search in Google Scholar

Omidi A, Riahinia N, Montazer Torbati MB, Behdani MA. (2014). Hepatoprotective effect of Crocus sativus (saffron) petals extract against acetaminophen toxicity in male Wistar rats. Avicenna J Phytomed4: 330–336.Search in Google Scholar

Pan TL, Wu TH, Wang PW, Leu YL, Sintupisut N, Huang CH, Chang FR, Wu YC. (2013). Functional proteomics reveals the protective effects of saffron ethanolic extract on hepatic ischemia-reperfusion injury. Proteomics13: 2297–2311.10.1002/pmic.201200551Search in Google Scholar

Premkumar K, Abraham SK, Santhiya ST, Ramesh A. (2003). Protective effects of saffron (Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice. Phytother Res17: 614–617.10.1002/ptr.1209Search in Google Scholar

Samarghandian S, Azimi-Nezhad M, Farkhondeh T. (2017). Immunomodulatory and antioxidant effects of saffron aqueous extract (Crocus sativus L.) on streptozotocin-induced diabetes in rats. Indian Heart J69: 151–159.10.1016/j.ihj.2016.09.008Search in Google Scholar

Samarghandian S, Azimi-Nezhad M, Samini F. (2014). Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. Biomed Res Int2014: 920857.10.1155/2014/920857Search in Google Scholar

Shati AA, Alamri SA. (2010). Role of saffron (Crocus sativus L.) and honey syrup on aluminum-induced hepatotoxicity. Saudi Med J31: 1106–1113.Search in Google Scholar

Schrek R, Stefani SS. (1976). Inhibition by ionophore A23187 of the cytotoxicity of vincristine, colchicine and X-rays to leukemic lymphocytes. Oncology33: 132–135.10.1159/000225126Search in Google Scholar

Silverman JA, Deitcher SR. (2013). Marqibo(R) (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine. Cancer Chemother Pharmacol71: 555–564.10.1007/s00280-012-2042-4Search in Google Scholar

Takano Y, Okudaira M, Harmon BV. (1993). Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathology, research and practice189: 197–203.10.1016/S0344-0338(11)80092-0Search in Google Scholar

Tavilani H, Doosti M, Saeidi H. (2005). Malondialdehyde levels in sperm and seminal plasma of asthenozoospermic and its relationship with semen parameters. Clin Chim Acta356: 199–203.10.1016/j.cccn.2005.01.017Search in Google Scholar

Thakur V, Kush P, Pandey RS, Jain UK, Chandra R, Madan J. (2016). Vincristine sulfate loaded dextran microspheres amalgamated with thermosensitive gel offered sustained release and enhanced cytotoxicity in THP-1, human leukemia cells: In vitro and in vivo study. Mater Sci Eng C Mater Biol Appl61: 113–122.10.1016/j.msec.2015.12.015Search in Google Scholar

van Tellingen O, Sips JH, Beijnen JH, Bult A, Nooijen WJ. (1992). Pharmacology, bio-analysis and pharmacokinetics of the vinca alkaloids and semi-synthetic derivatives (review). Anticancer Res12: 1699–1715.Search in Google Scholar

Verma SK, Bordia A. (1998). Antioxidant property of Saffron in man. Indian J Med Sci52: 205–207.Search in Google Scholar