Acceso abierto

Acute administration of nicotine does not enhance cognitive functions


1. World Health Organization (WHO). Global report on trends in prevalence of tobacco smoking: Prevalence of tobacco smoking 2015 [displayed 24 January 2018]. Available at;jsessionid=35A9E5884B89550AA678B616550FE249?sequence=1Search in Google Scholar

2. West R. Beneficial effects of nicotine: fact or fiction? Addiction 1993;88:589–90. doi: 10.1111/j.1360-0443.1994.tb00868.x10.1111/j.1360-0443.1994.tb00868.x8043039Open DOISearch in Google Scholar

3. Heishman SJ, Taylor RC, Henningfield JE. Nicotine and smoking: A review of effects on human performance. Exp Clin Psychopharmacol 1994;2:345–95. doi: 10.1037/1064-1297.2.4.34510.1037/1064-1297.2.4.345Open DOISearch in Google Scholar

4. Heishman SJ, Kleykamp BA, Singleton EG. Meta-analysis of the acute effects of nicotine and smoking on human performance. Psychopharmacology (Berl) 2010;210:453–69. doi: 10.1007/s00213-010-1848-110.1007/s00213-010-1848-1Open DOISearch in Google Scholar

5. Di Matteo V, Pierucci M, Di Giovanni G, Benigno A, Esposito E. The neurobiological bases for the pharmacotherapy of nicotine addiction. Curr Pharm Des 2007;13:1269–84. doi: 10.2174/13816120778061892010.2174/138161207780618920Open DOISearch in Google Scholar

6. Poorthuis RB, Goriounova NA, Couey JJ, Mansvelder HD. Nicotinic actions on neural networks for cognition: General principles and long-term consequences. Biochem Pharmacol 2009;78:668–76. doi: 10.1016/j.bcp.2009.04.03110.1016/j.bcp.2009.04.031Open DOISearch in Google Scholar

7. Mansvelder HD, van Aerde KI, Couey JJ, Brussaard AB. Nicotinic modulation of neuronal networks: from receptors to cognition. Psychopharmacology (Berl) 2006;184:292–305. doi: 10.1007/s00213-005-0070-z10.1007/s00213-005-0070-zOpen DOISearch in Google Scholar

8. Lawrence NS, Ross TJ, Stein EA. Cognitive mechanisms of nicotine on visual attention. Neuron 2002;36:539–48. doi: 10.1016/s0896-6273(02)01004-810.1016/S0896-6273(02)01004-8Search in Google Scholar

9. Foulds J, Stapleton J, Swettenham J, Bell N, McSorley K, Russel MAH. Cognitive performance effects of subcutaneous nicotine in smokers and never-smokers. Psychopharmacology (Berl) 1996;127:31–8. doi: 10.1007/bf0280597210.1007/BF028059728880941Search in Google Scholar

10. File SE, Fluck E, Leahy A. Nicotine has calming effects on stress-induced mood changes in females, but enhances aggressive mood in males. Int J Neuropsychopharmacol 2001;4:371–6. doi: 10.1017/S146114570100257711806862Search in Google Scholar

11. Levin ED, Conners CK, Silva D, Hinton SC, Meck WH, March J, Rose JE. Transdermal nicotine effects on attention. Psychopharmacology (Berl) 1998;140:135–41. doi: 10.1007/s00213005075010.1007/s0021300507509860103Open DOISearch in Google Scholar

12. Poltavski DV, Petros T. Effects of transdermal nicotine on attention in adult non-smokers with and without attentional deficits. Physiol Behav 2006;87:614–24. doi: 10.1016/j.physbeh.2005.12.01110.1016/j.physbeh.2005.12.01116466655Open DOISearch in Google Scholar

13. Hahn B, Thomas RJ, Wolkenberg FA, Shakleya DM, Huestis MA, Stein EA. Performance effects of nicotine during selective attention, divided attention, and simple stimulus detection: an fMRI study. Cereb Cortex 2009;19:1990–2000. doi: 10.1093/cercor/bhn22610.1093/cercor/bhn226Open DOISearch in Google Scholar

14. Smucny J, Ollncy A, Eichman LS, Tregellas JR. Neuronal effects of nicotine during auditory selective attention. Psychopharmacology 2015;232:2017–28. doi: 10.1007/s00213-014-3832-710.1007/s00213-014-3832-7Open DOISearch in Google Scholar

15. Barr RS, Culhane MA, Jubek LE, Mufti RS, Dyer MA, Weiss AP, Deckersbach T, Kelly JF, Freudenreich O, Goff DC, Evins AE. The effects of transdermal nicotine on cognition in nonsmokers with schizophrenia and nonpsychiatric controls. Neuropsychopharmacology 2008;33:480–90. doi: 10.1038/sj.npp.130142310.1038/sj.npp.1301423Open DOISearch in Google Scholar

16. Rezvani AH, Levin ED. Cognitive effects of nicotine. Biol Psych 2001;49:258–67. doi: 10.1016/S0006-3223(00)01094-510.1016/S0006-3223(00)01094-5Open DOISearch in Google Scholar

17. Levin ED. Nicotinic agonist and antagonist effects on memory. Drug Dev Res 1996;38:188–95. doi: 10.1002/(SICI)1098-2299(199607/08)38:3/43.0.CO;2-I10.1002/(SICI)1098-2299(199607/08)38:3/43.0.CO;2-Open DOISearch in Google Scholar

18. Levin ED, Simon BB. Nicotinic acetylcholine involvement in cognitive functions in animals. Psychopharmacology (Berl) 1998;138:217–30. doi: 10.1007/s00213005066710.1007/s002130050667Open DOISearch in Google Scholar

19. Kumari V, Gray JA, Ffytche DH, Mitterschiffthaler MT, Das M, Zachariah E, Vythelingum GN, Williams SCR, Simmons A, Sharma T. Cognitive effects of nicotine in humans: an fMRI study. NeuroImage 2003;19:1002–13. doi: 10.1016/S1053-8119(03)00110-112880828Search in Google Scholar

20. Heishman SJ, Henningfield JE. Tolerance to repeated nicotine administration on performance, subjective, and physiological responses in nonsmokers. Psychopharmacology (Berl) 2000;152:321–33. doi: 10.1007/s00213000054110.1007/s002130000541Open DOISearch in Google Scholar

21. Kleykamp BA, Jennings JM, Blank MD, Eissenberg T. The effects of nicotine on attention and working memory in never-smokers. Psychol Addict Behav 2005;19:433–8. doi: 10.1037/0893-164X.19.4.43310.1037/0893-164X.19.4.433Search in Google Scholar

22. Myers CS, Taylor RC, Moolchan ET, Heishman SJ. Dose-related enhancement of mood and cognition in smokers administered nicotine nasal spray. Neuropsychopharmacology 2008;33:588–98. doi: 10.1038/sj.npp.130142510.1038/sj.npp.1301425Open DOISearch in Google Scholar

23. Ernst M, Matochik JA, Heishman SJ, Van Horn JD, Jons PH, Henningfield JE, London ED. Effect of nicotine on brain activation during performance of a working memory task. PNAS 2001;98:4728–33. doi: 10.1073/pnas.06136909810.1073/pnas.061369098Open DOISearch in Google Scholar

24. Michel CM, Kaufman L, Wiliamson SJ. Duration of EEG and MEG α suppression increases with angle in a mental rotation task. J Cogn Neurosci 1994;6:139–50. doi: 10.1162/jocn.1994.6.2.13910.1162/jocn.1994.6.2.139Open DOISearch in Google Scholar

25. Cohen MS, Kosslyn SM, Breiter HC, DiGirolamo GJ, Thompson WL, Andreson AK, Brookheimer SY, Rosen BR, Belliveau JW. Changes in cortical activity during mental rotation. A mapping study using functional MRI. Brain 1996;119:89–100. doi: 10.1093/brain/119.1.8910.1093//119.1.89Open DOISearch in Google Scholar

26. Alivisatos B, Petrides M. Functional activation of human brain during mental rotation. Neuropsychologia 1997;35:111–8. doi: 10.1016/S0028-3932(96)00083-810.1016/S0028-3932(96)00083-8Search in Google Scholar

27. Serrati C, Finnocchi C, Calautti C, Bruzzone GL, Colucci M, Gandolfo C, Del Sette M, Lantieri PB, Favale E. Absence of hemispheric dominance for mental rotation ability: A transcranial Doppler study. Cortex 2000;36:415–25. doi: 10.1016/s0010-9452(08)70850-510.1016/S0010-9452(08)70850-5Open DOISearch in Google Scholar

28. Richter W, Somorjai R, Summers R, Jarmasz M, Menon RS, Gati JS, Georgopolus AP, Tegler C, Ugurbil K, Kim SG. Motor area activity during mental rotation studied by time-resolved single-trial fMRI. J Cogn Neurosci 2000;12:310–20. doi: 10.1162/08989290056212910.1162/089892900562129Open DOISearch in Google Scholar

29. Cabeza R, Nyberg L. Imaging condition II: An empirical review of 275 PET and fMRI studies. J Cogn Neurosci 2000;12:1–47. doi: 10.1162/0898929005113758510.1162/08989290051137585Open DOISearch in Google Scholar

30. Jordan K, Heinze HJ, Lutz K, Kanowski M, Jäncke L. Cortical activations during the mental rotation of different visual objects. NeuroImage 2001;13:143–52. doi: 10.1006/nimg.2000.067710.1006/nimg.2000.0677Open DOISearch in Google Scholar

31. Michel CM, Thut G, Morand S, Khateb A, Pegna AJ, Grave de Peralta R, Gonzalez S, Seeck M, Landis T. Electric source imaging of human brain functions. Brain Res Rev 2001;36:108–18. doi: 10.1016/S0165-0173(01)00086-810.1016/S0165-0173(01)00086-8Open DOISearch in Google Scholar

32. Ark WS. Neuroimaging studies give new insight to mental rotation. Proceedings of the 35th Hawaii International Conference on System Sciences 2002 [displayed 1 October 2019]. Available at in Google Scholar

33. Levin SL, Mohamed FB, Platek SM. Common ground for spatial cognition? A behavioural and fMRI study of sex differences in mental rotation and spatial working memory. Evol Psychol 2005;3:227–54. doi: 10.1177/14747049050030011610.1177/147470490500300116Open DOISearch in Google Scholar

34. Luo H, Ni JT, Li ZH, Li XO, Zhang DR, Zeng FG, Chen L. Opposite patterns of hemisphere dominance for early auditory processing of lexical tones and consonants. PNAS 2006;103:19558–63. doi: 10.1073/pnas.060706510410.1073/pnas.0607065104174826417159136Open DOISearch in Google Scholar

35. Vossel S, Thiel CM, Fink GR. Behavioral and neural effects of nicotine on visuospatial attentional reorienting in non-smoking subjects. Neuropsychopharmacology 2008;33:731–8. doi: 10.1038/sj.npp.130146917551539Search in Google Scholar

36. Bates T, Mangan G, Stough C, Corballis P. Smoking, processing speed and attention in a choice reaction time task. Psychopharmacology (Berl) 1995;120:209–12. doi: 10.1007/bf0224619510.1007/bf02246195Open DOISearch in Google Scholar

37. Iwaki T, Tamaki M, Hayashi M, Hori T. An exploratory study of effects of smoking on mental rotation and mental paper-folding task. Percept Mot Skills 1998;87:1171–82. doi: 10.2466/pms.1998.87.3f.117110.2466/pms.1998.87.3f.1171Open DOISearch in Google Scholar

38. Neumann DL, Fitzgerald ZT, Furedy JJ, Boyle GJ. Sexually dimorphic effects of acute nicotine administration on arousal and visual-spatial ability in non-smoking human volunteers. Pharmacol Biochem Behav 2007;86:758–65. doi: 10.1016/j.pbb.2007.03.00110.1016/j.pbb.2007.03.001Open DOISearch in Google Scholar

39. Smith AP, Rusted JM, Eaton-Williams P, Savory M, Leathwood P. Effects of caffeine given before and after lunch on sustained attention. Neuropsychobiology 1990;23:160–3. doi: 10.1159/00011944410.1159/000119444Open DOISearch in Google Scholar

40. Psychology Software Tools. E-Prime 2.0 Reference Guide Manual, 2012 [displayed 1 October 2019]. Available at in Google Scholar

41. Vogel EK, McCollough AW, Machizawa MG. Neural measures reveal individual differences in controlling access to working memory. Nature 2005;438:500–3. doi: 10.1038/nature0417110.1038/04171Open DOISearch in Google Scholar

42. Government Laboratory of the Government of the Hong Kong Special Administrative Region. Tar and Nicotine Report 2018 [displayed 3 August 2019]. Available at in Google Scholar

43. Pritchard WS, Robinson JH, Guy TD. Enhancement of continuous performance task reaction time by smoking in non-deprived smokers. Psychopharmacology (Berl) 1991:108;437–42. doi: 10.1007/bf0224741710.1007/BF02247417Open DOISearch in Google Scholar

44. Ernst M, Heishman SJ, Spurgeon L, London ED. Smoking history and nicotine effects on cognitive performance. Neuropsychopharmacology 2001;25:313–9. doi: 10.1016/S0893-133X(01)00257-310.1016/S0893-133X(01)00257-3Open DOISearch in Google Scholar

Inglés, Slovenian
Calendario de la edición:
4 veces al año
Temas de la revista:
Medicine, Basic Medical Science, other