This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Appleton CT. Osteoarthritis year in review 2017: Biology. Osteoarthritis Cartilage. 2018;26:296-303.10.1016/j.joca.2017.10.00829061493AppletonCT.Osteoarthritis year in review 2017: Biology201826296303Open DOISearch in Google Scholar
Watt FE. Osteoarthritis biomarkers: Year in review. Osteoarthritis Cartilage. 2018;26:312-318.10.1016/j.joca.2017.10.01629107060WattFE.Osteoarthritis biomarkers: Year in review201826312318Open DOISearch in Google Scholar
Abarca-Buis RF, Martínez-Jiménez A, Vera-Gómez E, et al. Mechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-α administration differ during wound repair and regeneration. Differentiation. 2018;99:10-20.2926823610.1016/j.diff.2017.12.001Abarca-BuisRFMartínez-JiménezAVera-GómezEMechanisms of epithelial thickening due to IL-1 signalling blockade and TNF-α administration differ during wound repair and regeneration2018991020Search in Google Scholar
Okla M, Zaher W, Alfayez M, Alfayez M, Chung S. Inhibitory effects of toll-like receptor 4, NLRP3 inflammasome, and interleukin-1β on white adipocyte browning. Inflammation. 2017;2:626-642. 10.1007/s10753-017-0718-y.OklaMZaherWAlfayezMAlfayezMChungS.Inhibitory effects of toll-like receptor 4, NLRP3 inflammasome, and interleukin-1β on white adipocyte browning2017262664210.1007/s10753-017-0718-yOpen DOISearch in Google Scholar
Shen HB, Huo ZJ, Bai YJ, et al. Protective effect of norcantharidin on collagen-induced arthritis rats. Chin J Integr Med. 2018;24:278-283. 10.1007/S11655-017-2792-2.29264841ShenHBHuoZJBaiYJProtective effect of norcantharidin on collagen-induced arthritis rats20182427828310.1007/S11655-017-2792-2Open DOISearch in Google Scholar
Hwang HS, Park SJ, Lee MH, et al. MicroRNA-365 regulates IL-1β-induced catabolic factor expression by targeting HIF-2α in primary chondrocytes. Sci Rep. 2017;7:17889.10.1038/s41598-017-18059-629263346HwangHSParkSJLeeMHMicroRNA-365 regulates IL-1β-induced catabolic factor expression by targeting HIF-2α in primary chondrocytes2017717889Open DOISearch in Google Scholar
Zhou ZB, Du D, Chen A, Zhu L. Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis. Gene. 2018;644:20-26.10.1016/j.gene.2017.12.020ZhouZBDuDChenAZhuL.Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis20186442026Open DOISearch in Google Scholar
Attur M, Statnikov A, Samuels J, et al. Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis. Osteoarthritis Cartilage. 2015;23:1915-1924.2652173710.1016/j.joca.2015.08.006AtturMStatnikovASamuelsJPlasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis20152319151924Search in Google Scholar
Oligino T, Ghivizzani S, Wolfe D, et al. Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis. Gene Ther. 1999;6:1713-1720.10.1038/sj.gt.3301014OliginoTGhivizzaniSWolfeDIntra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis1999617131720Open DOISearch in Google Scholar
Swellam M, Gabal KM, Youssef SS. Interleukin-1 receptor antagonist gene polymorphism and hepcidin in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity. IUBMB Life. 2013;65:883-888.24014495SwellamMGabalKMYoussefSS.Interleukin-1 receptor antagonist gene polymorphism and hepcidin in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity20136588388810.1002/iub.1205Search in Google Scholar
Martín-Sánchez F, Martínez-García JJ, Muñnoz-García M, et al. Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1β release. Cell Death Dis. 2017;8:e2984.2879626410.1038/cddis.2017.390Martín-SánchezFMartínez-GarcíaJJMuñnoz-GarcíaMLytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1β release20178e2984Search in Google Scholar
Xing D, Gao H, Liu Z, Zhao Y, Gong M. Baicalin inhibits inflammatory responses to interleukin-1β stimulation in human chondrocytes. J Interferon Cytokine Res. 2017;37:398-405.10.1089/jir.2017.003028829242XingDGaoHLiuZZhaoYGongM.Baicalin inhibits inflammatory responses to interleukin-1β stimulation in human chondrocytes201737398405Open DOISearch in Google Scholar
Takemiya T, Takeuchi C, Kawakami M. Microsomal prostaglandin e synthase-1 facilitates an intercellular interaction between CD4+ T cells through IL-1β autocrine function in experimental autoimmune encephalomyelitis. Int J Mol Sci. 2017;18:2758.10.3390/ijms18122758TakemiyaTTakeuchiCKawakamiM.Microsomal prostaglandin e synthase-1 facilitates an intercellular interaction between CD4+ T cells through IL-1β autocrine function in experimental autoimmune encephalomyelitis2017182758Open DOISearch in Google Scholar
Franco L, Williams FM, Trofimov S, Surdulescu G, Spector T, Livshits G. Elevated plasma fractalkine levels are associated with higher levels of IL-6, Apo-B, LDL-C and insulin, but not with body composition in a large female twin sample. Metabolism. 2013;62:1081-1087.10.1016/j.metabol.2013.02.001FrancoLWilliamsFMTrofimovSSurdulescuGSpectorTLivshitsG.Elevated plasma fractalkine levels are associated with higher levels of IL-6, Apo-B, LDL-C and insulin, but not with body composition in a large female twin sample20136210811087Open DOISearch in Google Scholar
Hiraoka N, Takahashi KA, Arai Y, et al. Intra-articular injection of hyaluronan restores the aberrant expression of matrix metalloproteinase-13 in osteoarthritic subchondral bone. J Orthop Res. 2011;29:354-360.2088664710.1002/jor.21240HiraokaNTakahashiKAAraiYIntra-articular injection of hyaluronan restores the aberrant expression of matrix metalloproteinase-13 in osteoarthritic subchondral bone201129354360Search in Google Scholar
Livshits G, Zhai G, Hart DJ, et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study. Arthritis Rheum. 2009;60:2037-2045.10.1002/art.2459819565477LivshitsGZhaiGHartDJInterleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study20096020372045Open DOISearch in Google Scholar
Latourte A, Cherifi C, Maillet J, et al. Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis. J Ann Rheum Dis. 2017;76:748-755.10.1136/annrheumdis-2016-209757LatourteACherifiCMailletJSystemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis201776748755Open DOISearch in Google Scholar
Li YS, Luo W, Zhu SA, Lei GH. T cells in osteoarthritis: Alterations and beyond. Front Immunol. 2017;8:356.28424692LiYSLuoWZhuSALeiGH.T cells in osteoarthritis: Alterations and beyond2017835610.3389/fimmu.2017.00356Search in Google Scholar
Annunziato F, Romagnani S. Mouse T helper 17 phenotype: Not so different than in man after all. Cytokine. 2011;56:112-115.10.1016/j.cyto.2011.06.009AnnunziatoFRomagnaniS.Mouse T helper 17 phenotype: Not so different than in man after all201156112115Open DOISearch in Google Scholar
Bush KA, Farmer KM, Walker JS, Kirkham BW. Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum. 2002;46:802-805.10.1002/art.1017311920418BushKAFarmerKMWalkerJSKirkhamBW.Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein200246802805Open DOISearch in Google Scholar
Noone C, Parkinson M, Dowling DJ, et al. Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum. Malar J. 2013;12:5.10.1186/1475-2875-12-523294670NooneCParkinsonMDowlingDJPlasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum2013125Open DOISearch in Google Scholar
Mobasheri A, Rayman MP, Gualillo O, Sellam J, van der Kraan P, Fearon U. The role of metabolism in the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2017;13:302-311.10.1038/nrrheum.2017.5028381830MobasheriARaymanMPGualilloOSellamJvan der KraanPFearonU.The role of metabolism in the pathogenesis of osteoarthritis201713302311Open DOISearch in Google Scholar
Minkwitz S, Schmock A, Kurtoglu A, et al. Timedependent alterations of MMPs, TIMPs and tendon structure in human achilles tendons after acute rupture. Int J Mol Sci. 2017;18:pii:E2199.10.3390/ijms18102199MinkwitzSSchmockAKurtogluATimedependent alterations of MMPs, TIMPs and tendon structure in human achilles tendons after acute rupture201718piiE2199Open DOISearch in Google Scholar
Adams SB, Setton LA, Bell RD, et al. Inflammatory cytokines and matrix metalloproteinases in the synovial fluid after intra-articular ankle fracture. Foot Ankle Int. 2015;36:1264-1271.2644938910.1177/1071100715611176AdamsSBSettonLABellRDInflammatory cytokines and matrix metalloproteinases in the synovial fluid after intra-articular ankle fracture20153612641271Search in Google Scholar
Huang TL, Yang CH, Yanai G, Liao JY, Sumi S, Yang KC. Synergistic effect of l-ascorbic acid and hyaluronic acid on the expressions of matrix metalloproteinase-3 and -9 in human chondrocytes. J Biomed Mater Res B Appl Biomater. 2017 Sep 15. 10.1002/jbm.b.33988.28914997HuangTLYangCHYanaiGLiaoJYSumiSYangKC.Synergistic effect of l-ascorbic acid and hyaluronic acid on the expressions of matrix metalloproteinase-3 and -9 in human chondrocytes2017Sep 1510.1002/jbm.b.33988Open DOISearch in Google Scholar
Zwerina J, Redlich K, Polzer K, et al. TNF-induced structural joint damage is mediated by IL-1. Proc Natl Acad Sci U S A. 2007;104:11742-11747.1760938910.1073/pnas.0610812104ZwerinaJRedlichKPolzerKTNF-induced structural joint damage is mediated by IL-120071041174211747Search in Google Scholar
Botha-Scheepers S, Watt I, Slagboom E, et al. Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis. Ann Rheum Dis. 2008;67:1165-1169.1802938310.1136/ard.2007.084657Botha-ScheepersSWattISlagboomEInnate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis20086711651169Search in Google Scholar
Stannus O, Jones G, Cicuttini F, et al. Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage. 2010;18:1441-1447.10.1016/j.joca.2010.08.01620816981StannusOJonesGCicuttiniFCirculating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults20101814411447Open DOISearch in Google Scholar
Gerstenfeld LC, Cho TJ, Kon T, et al. Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs. 2001;169:285-294.1145512510.1159/000047893GerstenfeldLCChoTJKonTImpaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling2001169285294Search in Google Scholar
Brennan FM, Gibbons DL, Cope AP, Katsikis P, Maini RN, Feldmann M. TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: Evidence of feedback control of TNF action. Scand J Immunol. 1995;42:158-165.763113810.1111/j.1365-3083.1995.tb03639.xBrennanFMGibbonsDLCopeAPKatsikisPMainiRNFeldmannM.TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: Evidence of feedback control of TNF action199542158165Search in Google Scholar
Silvestri T, Pulsatelli L, Dolzani P, Facchini A, Meliconi R. Elevated serum levels of soluble interleukin-4 receptor in osteoarthritis. Osteoarthritis Cartilage. 2006;14:717-719.1664727710.1016/j.joca.2006.02.015SilvestriTPulsatelliLDolzaniPFacchiniAMeliconiR.Elevated serum levels of soluble interleukin-4 receptor in osteoarthritis200614717719Search in Google Scholar
Campana L, Starkey Lewis PJ, Pellicoro A, et al. The STAT3-IL-10-IL-6 pathway is a novel regulator of macrophage efferocytosis and phenotypic conversion in sterile liver injury. J Immunol. 2018;200:1169-1187.10.4049/jimmunol.170124729263216CampanaLStarkey LewisPJPellicoroAThe STAT3-IL-10-IL-6 pathway is a novel regulator of macrophage efferocytosis and phenotypic conversion in sterile liver injury201820011691187Open DOISearch in Google Scholar
Helmark IC, Mikkelsen UR, Børglum J, et al. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: A randomized controlled trial. Arthritis Res Ther. 2010;12:R126.20594330HelmarkICMikkelsenURBørglumJExercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: A randomized controlled trial201012R12610.1186/ar3064Search in Google Scholar
Ping Z, Wang ZR, Shi JW, et al. Inhibitory effects of melatonin on titanium particle-induced inflammatory bone resorption and osteoclastogenesis via suppression of NF-κB signaling. Acta Biomater. 2017;62:362-371.2886764710.1016/j.actbio.2017.08.046PingZWangZRShiJWInhibitory effects of melatonin on titanium particle-induced inflammatory bone resorption and osteoclastogenesis via suppression of NF-κB signaling201762362371Search in Google Scholar
Hou SM, Hou CH, Liu JF. CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts. Arthritis Res Ther. 2017;19:282.2926876810.1186/s13075-017-1487-6HouSMHouCHLiuJF.CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts201719282Search in Google Scholar
Huang XJ, Pan QY, Mao ZK, et al. Sinapic acid inhibits the IL-1β-induced inflammation via MAPK downregulation in rat chondrocytes. Inflammation. 2017 Dec 14. 10.1007/s10753-017-0712-4.HuangXJPanQYMaoZKSinapic acid inhibits the IL-1β-induced inflammation via MAPK downregulation in rat chondrocytes2017Dec 1410.1007/s10753-017-0712-4Open DOISearch in Google Scholar
Yang XT, He HC, Gao Q, He CQ. Pulsed electromagnetic field improves subchondral bone microstructure in knee osteoarthritis rats through a Wnt/β-catenin signaling-associated mechanism. Bioelectromagnetics. 2018;39:89-97. 18.10.1002/bem.22106.29251361YangXTHeHCGaoQHeCQ.Pulsed electromagnetic field improves subchondral bone microstructure in knee osteoarthritis rats through a Wnt/β-catenin signaling-associated mechanism201839899718.10.1002/bem.22106Open DOISearch in Google Scholar
Pan TL, Shi XC, Chen H, et al. Geniposide suppresses interleukin-1β-induced inflammation and apoptosis in rat chondrocytes via the PI3K/Akt/NF-κB signaling pathway. J. Inflammation. 2017 Dec 6. 10.1007/s10753-017-0694-2.PanTLShiXCChenHGeniposide suppresses interleukin-1β-induced inflammation and apoptosis in rat chondrocytes via the PI3K/Akt/NF-κB signaling pathway2017Dec 610.1007/s10753-017-0694-2Open DOISearch in Google Scholar
Zheng W, Chen C, Zhang C, Cai L, Chen H. The protective effect of phloretin in osteoarthritis: An in vitro and in vivo study. Food Funct. 2018;9:263-278.10.1039/C7FO01199GZhengWChenCZhangCCaiLChenH.The protective effect of phloretin in osteoarthritis: An in vitro and in vivo study20189263278Open DOISearch in Google Scholar
Hu H, Yang B, Li Y, Zhang S, Li Z. Blocking of the P2×7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis. Int J Mol Med. 2016;38: 1922-1932.10.3892/ijmm.2016.277027748894HuHYangBLiYZhangSLiZ.Blocking of the P2×7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis20163819221932Open DOISearch in Google Scholar
Zhou Y, Ming J, Li Y, et al. Surfactant protein D attenuates nitric oxide-stimulated apoptosis in rat chondrocyte by suppressing p38 MAPK signaling. Biochem Biophys Res Commun. 2018;495:526-532.10.1016/j.bbrc.2017.10.17029101035ZhouYMingJLiYSurfactant protein D attenuates nitric oxide-stimulated apoptosis in rat chondrocyte by suppressing p38 MAPK signaling2018495526532Open DOISearch in Google Scholar
Zeng L, Rong XF, Li RH, Wu XY. Icariin inhibits MMP-1, MMP-3 and MMP-13 expression through MAPK pathways in IL-1β-stimulated SW1353 chondrosarcoma cells. Mol Med Rep. 2017;15:2853-2858.10.3892/mmr.2017.6312ZengLRongXFLiRHWuXY.Icariin inhibits MMP-1, MMP-3 and MMP-13 expression through MAPK pathways in IL-1β-stimulated SW1353 chondrosarcoma cells20171528532858Open DOISearch in Google Scholar
Chen WP, Jin GJ, Xiong Y, Hu PF, Bao JP, Wu LD. Rosmarinic acid down-regulates NO and PGE2 expression via MAPK pathway in rat chondrocytes. J Cell Mol Med. 2018;22:346-353.10.1111/jcmm.1332228945000ChenWPJinGJXiongYHuPFBaoJPWuLD.Rosmarinic acid down-regulates NO and PGE2 expression via MAPK pathway in rat chondrocytes201822346353Open DOISearch in Google Scholar
Zhou Y, Liu SQ, Yu L, et al. Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling. Apoptosis. 2015;20:1187-1199.10.1007/s10495-015-1152-yZhouYLiuSQYuLBerberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling20152011871199Open DOISearch in Google Scholar
Liu S, Yang HP, Hu B, Zhang MY. Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/β-catenin signaling pathways. Exp Ther Med. 2017;14:5057-5062.29201214LiuSYangHPHuBZhangMY.Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/β-catenin signaling pathways2017145057506210.3892/etm.2017.5165Search in Google Scholar
Weng LH, Wang CJ, Ko JY, Sun YC, Su YS, Wang FS. Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint. Osteoarthritis Cartilage. 2009;17:933-943.10.1016/j.joca.2008.12.00819217321WengLHWangCJKoJYSunYCSuYSWangFS.Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint200917933943Open DOISearch in Google Scholar
Liao SY, Zhou K, Li DQ, Xie XM, Jun F, Wang J. Schisantherin A suppresses interleukin-1β-induced inflammation in human chondrocytes via inhibition of NF-κB and MAPKs activation. Eur J Pharmacol. 2016;780:65-70.2699736810.1016/j.ejphar.2016.03.032LiaoSYZhouKLiDQXieXMJunFWangJ.Schisantherin A suppresses interleukin-1β-induced inflammation in human chondrocytes via inhibition of NF-κB and MAPKs activation20167806570Search in Google Scholar