<abstract xmlns="http://www.w3.org/1999/xhtml">The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (<italic>n</italic> = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme, respectively. Carbopol gel, Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls. Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment. In the hot plate test, the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour. The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity.</abstract>

The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (n = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme, respectively. Carbopol gel, Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls. Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment. In the hot plate test, the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour. The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity.

<italic>In vivo</italic> investigation of antihyperalgesic and antinociceptive effects of peat formulations

Department of Biophysics, Faculty of Pharmacy

Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy

Department of Pharmaceutical Sciences, Faculty of Pharmacy

Department of Medical Biology, Medical Faculty

Technological Center of Emergency Medicine

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

 investigation of antihyperalgesic and antinociceptive effects of peat formulations

The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of...

In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations

Online veröffentlicht: 04. Juli 2018

Seitenbereich: 373 - 380

Akzeptiert: 22. März 2018

DOI: https://doi.org/10.2478/acph-2018-0029

Schlüsselwörter
peat, hyperalgesia, Wistar rats

© 2018 Plamen Ivanov Zagorchev et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations

Online veröffentlicht: 04. Juli 2018

Seitenbereich: 373 - 380

Akzeptiert: 22. März 2018

DOI: https://doi.org/10.2478/acph-2018-0029

Schlüsselwörterpeat, hyperalgesia, Wistar rats

© 2018 Plamen Ivanov Zagorchev et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
peat, hyperalgesia, Wistar rats