[1. van Dijk K, van der Bom JG, Fischer K, Grobbee DE, van den Berg HM. Do prothrombotic factors influence clinical phenotype of severe haemophilia? A review of the literature. Thromb Haemost. 2004 Aug;92(2):305-10.10.1160/TH04-02-0112]Search in Google Scholar
[2. Franchini M, Lippi G. Factor V Leiden and hemophilia. Thromb Res. 2010 Feb;125(2):119-23. DOI: 10.1016/j. thromres.2009.11.003]Search in Google Scholar
[3. Sanna V, Zarrilli F, Nardiello P, D’Argenio V, Rocino A, Coppola A, et al. Mutational spectrum of F8 gene and prothrombotic gene variants in haemophilia A patients from Southern Italy. Haemophilia. 2008 Jul;14(4):796-803. DOI: 10.1111/j.1365-2516.2008.01705.x10.1111/j.1365-2516.2008.01705.x]Search in Google Scholar
[4. Dargaud Y, Meunier S, Negrier C. Haemophilia and thrombophilia: an unexpected association! Haemophilia. 2004 Jul;10(4):319-26. DOI: 10.1111/j.1365-2516.2004.00906.x10.1111/j.1365-2516.2004.00906.x]Search in Google Scholar
[5. Kurnik K, Kreuz W, Horneff S, Düring C, Schobess R, Bidlingmaier C, et al. Effects of the factor V G1691A mutation and the factor II G20210A variant on the clinical expression of severe hemophilia A in children--results of a multicenter study. Haematologica. 2007 Jul;92(7):982-5. DOI: 10.3324/haematol.1116110.3324/haematol.11161]Search in Google Scholar
[6. Bertina RM, Koeleman BPC, Koster T, et al. Mutation in blood coagulation factor V - associated with resistance to activated protein C. Nature. 1994 May 5; 369(6475):64-7. DOI: 10.1038/369064a010.1038/369064a0]Search in Google Scholar
[7. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3`-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996 Nov 15;88(10):3698-703.10.1182/blood.V88.10.3698.bloodjournal88103698]Search in Google Scholar
[8. Födinger M, Hörl WH, Sunder-Plassmann G. Molecular biology of 5, 10-methylenetetrahydrofolate reductase. J Nephrol. 2000 Jan-Feb;13(1):20-33.]Search in Google Scholar
[9. Schneider JA, Rees DC, Liu YT, Clegg JB. Worldwide distribution of a common Methylenetetrahydrofolate reductase mutation. Am J Hum Genet. 1998 May; 62(5):1258-60. DOI: 10.1086/30183610.1086/301836]Search in Google Scholar
[10. Abeer M, Hesham A. Genetic polymorphisms of Plasminogen Activator Inhibitor-1, vascular endothelial growth factor and angiotensin converting enzyme among pre-eclamptic women. Egypt J Med Lab Sci. 2010 Mar; 19(1):39-44.]Search in Google Scholar
[11. Nordt TK, Lohrmann J, Bode C. Regulation of PAI-1 expression by genetic polymorphisms. Impact on atherogenesis. Thromb Res. 2001 Sep;103 Suppl 1:S1-5.DOI: 10.1016/S0049-3848(01)00292-410.1016/S0049-3848(01)00292-4]Search in Google Scholar
[12. Falk G, Almquist A, Nordenhem A, Svensson H, Wiman B. Allele specific PCR for detection of a sequence polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene. Fibrinolysis. 1995 May;9(3):170-4. DOI: 10.1016/S0268-9499(95)80007-710.1016/S0268-9499(95)80007-7]Search in Google Scholar
[13. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995 May;10(1):111-3. DOI: 10.1038/ng0595-11110.1038/ng0595-1117647779]Search in Google Scholar
[14. Xenophontos SL, Hadjivassiliou M, Ayrton N, Karagrigoriou A, Pantzaris M, Nicolaides AN, et al. Spectrum and prevalence of prothrombotic single nucleotide polymorphism profiles in the Greek Cypriot population. Int Angiol. 2002 Dec;21(4):322-9.]Search in Google Scholar
[15. Saour JN, Shoukri MM, Mammo LA. The Saudi Thrombosis and Familial Thrombophilia Registry. Design, rational, and preliminary results. Saudi Med J. 2009 Oct; 30(10):1286-90.]Search in Google Scholar
[16. Hussein AS. High prevalence of three prothrombotic polymorphisms among Palestinians: factor V G1691A, factor II G20210A and methylenetetrahydrofolate reductase C677T. J Thromb Thrombolysis. 2012 Oct;34(3):383-7. DOI: 10.1007/s11239-012-0731-910.1007/s11239-012-0731-9]Search in Google Scholar
[17. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet. 1995 Oct;346(8983):1133-4. DOI: 10.1016/S0140-6736(95)91803-510.1016/S0140-6736(95)91803-5]Search in Google Scholar
[18. Lucotte G, Mercier G. Population genetics of factor V Leiden in Europe. Blood Cells Mol Dis. 2001 Mar- Apr;27(2):362-7. DOI: 10.1006/bcmd.2001.038810.1006/bcmd.2001.038811259157]Search in Google Scholar
[19. Roosendaal FR, Doggen C, Zivelin A, Arruda V, Aiach M. Geographic distribution of the 20210G to A prothrombin variant. Thromb Haemost. 1998 Apr;79(4):706-8.10.1055/s-0037-1615049]Search in Google Scholar
[20. Alfirevic Z, Simundic A, Nikolac N, Sobocan N, Alfirevic I, Stefanovic M, et al. Frequency of factor II G20210A, factor V Leiden, MTHFR C677T and PAI-1 5G/4G polymorphism in patients with venous thromboembolism: Croatian case control study. Biochemia Medica. 2010 Mar;20(2):229-35. DOI: 10.11613/ BM.2010.02810.11613/BM.2010.028]Search in Google Scholar
[21. Kvasnička T, Hájková J, Bobčíková P, Cverhová V, Malíková I, Ulrych J, et al. The Frequencies of Six Important Thrombophilic Mutations in a Population of the Czech Republic. Physiol Res. 2014 Jan;63(2):245-53.10.33549/physiolres.93261824397802]Search in Google Scholar
[22. Pepe G, Camacho Vanegas O, Giusti B, Brunelli T, Marcucci R, Attanasio M, et al. Heterogeneity in world distribution of the thermolabile C677T mutation in 5,10-Methylenetetrahydrofolate reductase. Am J Hum Genet. 1998 Sep;63(3):917-20. DOI: 10.1086/30201510.1086/30201513774039718345]Search in Google Scholar
[23. Hessner MJ, Luhm RA, Pearson SL, Endean DJ, Friedman KD, Montgomery RR. Prevalence of Prothrombin G20210A, Factor V G1691A (Leiden), and MethylenetetrahydrofolateReductase (MTHFR) C677T in Seven Different Populations Determined by Multiplex Allele-specific PCR. Thromb Haemost. 1999 May;81(5):733-8.10.1055/s-0037-1614563]Search in Google Scholar
[24. Escuriola Ettingshausen C, Halimeh S, Kurnik K, Schobess R, Wermes C, Junker R, et al. Symptomatic onset of severe hemophilia A in childhood is dependent on the presence of prothrombotic risk factors. Thromb Haemost. 2001 Feb;85(2):218-20.10.1055/s-0037-1615679]Search in Google Scholar
[25. Nowak-Göttl U, Escuriola C, Kurnik K, Schobess R, Horneff S, Kosch A, et al. Haemophilia and thrombophilia. What do we learn about combined inheritance of both genetic variations? Hämostaseologie. 2003 Feb;23(1):36-40.10.1055/s-0037-1619560]Search in Google Scholar
[26. Friedman G, Goldschmidt N, Friedlander Y, Ben-Yehuda A, Selhub J, Babaey S et al. A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations. J Nutr. 1999 Sep;129(9):1656-61.10.1093/jn/129.9.165610460200]Search in Google Scholar
[27. Bavikatty NR, Killeen AA, Akel N, Normolle D, Schmaier AH. Association of the prothrombin G20210A mutation with factor V Leiden in a midwestern American population. Am J Clin Pathol. 2000 Aug; 114(2):272-5. DOI: 10.1309/LQKG-F0D4-C6FFFNEH ]Search in Google Scholar