[1. Yannas IV, Burke JF. Design of an artificial skin I basic design principles. J Biomed Mater Res. 1980; 14:65-81.10.1002/jbm.820140108]Open DOISearch in Google Scholar
[2. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinising colonies from single cells. Cell. 1975; 6: 331-43.10.1016/S0092-8674(75)80001-8]Open DOISearch in Google Scholar
[3. Regnier M, Prunieras M, Woodley D. Growth and differentiation of adult human epidermal cells on dermal substrates. Front Matrix Biol. 1981; 9:4-35.]Search in Google Scholar
[4. Bell E, Sher S, Hull B, Merrill C, Rosen S, Chamson A, et al. The reconstitution of living skin. J Invest Dermatol. 1983; 81:S2-10.10.1111/1523-1747.ep12539993]Open DOISearch in Google Scholar
[5. Boyce ST, Michel S, Reichert U, Schroot B, Schmidt R. Reconstructed skin from cultured human keratinocytes and fibroblasts on a collagenglycosaminoglycan biopolymer substrate. Skin Pharmacol. 1990; 2:136-43.10.1159/000210860]Search in Google Scholar
[6. Waymack P, Duff RG, Sabolinski M. The effect of a tissue engineered bilayered living skin analog, over meshed split-thickness autografts on the healing of excised burn wounds. Burns. 2000; 26:609-19.10.1016/S0305-4179(00)00017-6]Open DOISearch in Google Scholar
[7. Veves A, Falanga V, Armstrong DG, Sabolinski ML. Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial. Diabetes Care. 2001; 24:290-5.10.2337/diacare.24.2.29011213881]Open DOISearch in Google Scholar
[8. Scates DM, Jack Hartwell JK. A comparison of the high count-rate performance of three commercially available digital signal processors. Appl Radiat Isot. 2005; 63: 465-73.10.1016/j.apradiso.2005.05.05216039134]Open DOISearch in Google Scholar
[9. MacNeil S. Progress and opportunities for tissueengineered skin. Nature. 2007; 445:870-80.10.1038/nature0566417314974]Search in Google Scholar
[10. Metcalfe AD, Ferguson MW. Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration. J R Soc Interface. 2007; 4:413-37.10.1098/rsif.2006.0179237341117251138]Open DOISearch in Google Scholar
[11. Rigel DS. Epidemiology of melanoma. Semin Cutan Med Surg. 2010; 29:204-9.10.1016/j.sder.2010.10.00521277533]Open DOISearch in Google Scholar
[12. Kwon HK, Hwang JS, So JS, Lee CG, Sahoo A, Ryu JH, et al. Cinnamon extract induces tumor cell death through inhibition of NF-B and AP1. BMC Cancer. 2010; 10:1-10.10.1186/1471-2407-10-392292088020653974]Open DOISearch in Google Scholar
[13. Cabello CM, Bair III WB, Lamore SD, Ley S, Bause AS, Azimian S, et al. The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radical Bio Med. 2009; 46:220-31.10.1016/j.freeradbiomed.2008.10.025265002319000754]Open DOISearch in Google Scholar
[14. Pandol☐no MC, Saiagh S, Knol AC, Dr☐no B. Comparison of three culture media for the establishment of melanoma cell line. Cytotechnology. 2010; 62: 403-12.10.1007/s10616-010-9286-9299386320730489]Open DOISearch in Google Scholar
[15. Niehr F, von Euw E, Attar N, Guo D, Matsunaga D, Sazegar H, et al. Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations. J Transl Med. 2011; 9:76.10.1186/1479-5876-9-76315278421609436]Open DOISearch in Google Scholar
[16. Eager RM, Cunningham CC, Senzer NN, Stephenson J Jr, Anthony SP, O’Day SJ, et al. Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma. BMC Cancer. 2009; 9:263.10.1186/1471-2407-9-263273178219643020]Open DOISearch in Google Scholar
[17. Hutmacher DW, Loessner D, Rizzi S, plan DL, Mooney DJ, Clements JA. Can tissue engineering concepts advance tumor biology research? Trends Biotechnol. 2010; 28:125-33.10.1016/j.tibtech.2009.12.00120056286]Open DOISearch in Google Scholar
[18. Eves P, Haycock J, Layton C, Wagner M, Kemp H, Szabo M, et al. Anti-inflammatory and anti-invasive effects of a-melanocytes stimulating hormone in human melanoma cells. Br J Cancer. 2003; 89:2004-15.10.1038/sj.bjc.6601349239444914612916]Open DOISearch in Google Scholar
[19. Mohapatra S, Coppola DO, Riker AI, Pledger WJ. Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanoma. Mol Cancer Res. 2007; 5:145-51.10.1158/1541-7786.MCR-06-030017314272]Open DOISearch in Google Scholar
[20. Yee CH, Aoki S, Uchihashi K, Matsunobu A, Yamasaki F, Misago N, et al. The air liquid-interface, a skin microenvironment, promotes growth of melanoma cells, but not their apoptosis and invasion, through activation of mitogen-activated protein kinase. Acta Histochem Cytochem. 2010; 43:1-7.10.1267/ahc.09036284022020300218]Open DOISearch in Google Scholar
[21. Kwon JA, Yu CB, Park HD. Bacteriocidal effects and inhibition of cell separation of cinnamic aldehyde on Bacillus cereus. Lett Appl Microbiol. 2003; 37:61-5.10.1046/j.1472-765X.2003.01350.x12803558]Open DOISearch in Google Scholar
[22. Bosserhoff AK. Novel biomarkers in malignant melanoma. Clinica Chimica Acta. 2006; 367:28-35.10.1016/j.cca.2005.10.02916480699]Search in Google Scholar
[23. Rodriguez D, Morrison CJ, Overall CM. Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics. Biochim Biophys Acta. 2010; 1803:39-54.10.1016/j.bbamcr.2009.09.01519800373]Search in Google Scholar
[24. Wang X, Nagase H, Watanabe T, Nobusue H, Suzuki T, Asami Y, et al. Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrroleimidazole polyamide. Cancer Sci. 2010; 101:759-66.10.1111/j.1349-7006.2009.01435.x20085585]Open DOISearch in Google Scholar
[25. Brooks SA, Lomax-Browne HJ, Carter TM, Kinch CE, Hall DM. Molecular interactions in cancer cell metastasis. Acta Histochem. 2010; 112:3-25.10.1016/j.acthis.2008.11.02219162308]Open DOISearch in Google Scholar
[26. Rodriguez M, Aladowicz E, Lanfrancone L, Goding CR. Tbx3 represses E-Cadherin expression and enhances melanoma invasiveness. Cancer Res. 2008; 68: 7872-81.10.1158/0008-5472.CAN-08-030118829543]Open DOISearch in Google Scholar
[27. Molina-Ortiz I, Bartolome RA, Hernandez-Varas P, Colo GP, Teixido J. Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA. J Biol Chem. 2009; 284:15147-57.10.1074/jbc.M807834200268569619293150]Search in Google Scholar
[28. Strzalka W, Ziemienowicz A. Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. Ann Bot. 2011; 107:1127-40.10.1093/aob/mcq243309179721169293]Open DOISearch in Google Scholar
[29. Salehinejad J, Zare-Mahmoodabadi R, Saghafi S, Jafarian AH, Ghazi N, Rajaei AR, et al. Immunohistochemical detection of p53 and PCNA in ameloblastoma and adenomatoid odontogenic tumor. J Oral Sci. 2011; 53:213-7.10.2334/josnusd.53.21321712626]Open DOISearch in Google Scholar
[30. Mateoiu C, Pirici A, Bogdan F. Immunohistochemical nuclear staining for p53, PCNA, Ki-67 and bcl-2 in different histologic variants of basal cell carcinoma. Rom J Morphol Embryol. 2011; 52(1 Suppl):315-19.]Search in Google Scholar
[31. Ben-Izhak O, Bar-Chana M, Sussman L, Dobiner V, Sandbank J, Cagnano M, et al. Ki67 antigen and PCNA proliferation markers predict survival in anorectal malignant melanoma. Histopathology. 2002; 41:519-25.10.1046/j.1365-2559.2002.01444.x12460204]Search in Google Scholar