<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress and aging they provide multiple biological health benefits. Ca2+-ATPases belong to the main calcium regulating proteins involved in the balance of calcium homeostasis, which is impaired in oxidative/nitrosative stress and related diseases or aging. The mechanisms of Ca2+-ATPases dysfunction are discussed, focusing on cystein oxidation and tyrosine nitration. Flavonoids act not only as antioxidants but are also able to bind directly to Ca2+-ATPases, thus changing their conformation, which results in modulation of enzyme activity.Dysfunction of Ca2+-ATPases is summarized with respect to their posttranslational and conformational changes in diseases related to oxidative/nitrosative stress and aging. Ca2+-ATPases are discussed as a therapeutic tool and the possible role of flavonoids in this process is suggested.</abstract>

Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress and aging they provide multiple biological health benefits. Ca2+-ATPases belong to the main calcium regulating proteins involved in the balance of calcium homeostasis, which is impaired in oxidative/nitrosative stress and related diseases or aging. The mechanisms of Ca2+-ATPases dysfunction are discussed, focusing on cystein oxidation and tyrosine nitration. Flavonoids act not only as antioxidants but are also able to bind directly to Ca2+-ATPases, thus changing their conformation, which results in modulation of enzyme activity.Dysfunction of Ca2+-ATPases is summarized with respect to their posttranslational and conformational changes in diseases related to oxidative/nitrosative stress and aging. Ca2+-ATPases are discussed as a therapeutic tool and the possible role of flavonoids in this process is suggested.

Flavonoids in prevention of diseases with respect to modulation of Ca-pump function

Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia

Interdisciplinary Toxicology

Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress...

Flavonoids in prevention of diseases with respect to modulation of Ca-pump function

Published Online: Oct 24, 2011

Page range: 114 - 124

DOI: https://doi.org/10.2478/v10102-011-0019-5

Keywords
flavonoids, oxidative/nitrosative stress, Ca-ATPases in aging and diseases

This content is open access.

Flavonoids in prevention of diseases with respect to modulation of Ca-pump function

Published Online: Oct 24, 2011

Page range: 114 - 124

DOI: https://doi.org/10.2478/v10102-011-0019-5

Keywordsflavonoids, oxidative/nitrosative stress, Ca-ATPases in aging and diseases

This content is open access.

Keywords
flavonoids, oxidative/nitrosative stress, Ca-ATPases in aging and diseases