1. bookVolume 4 (2011): Issue 2 (June 2011)
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eISSN
1337-9569
ISSN
1337-6853
First Published
19 Jun 2009
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4 times per year
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English
access type Open Access

Cardioprotective activity of flax lignan concentrate extracted from seeds of Linum usitatissimum in isoprenalin induced myocardial necrosis in rats

Published Online: 17 Jun 2011
Volume & Issue: Volume 4 (2011) - Issue 2 (June 2011)
Page range: 90 - 97
Journal Details
License
Format
Journal
eISSN
1337-9569
ISSN
1337-6853
First Published
19 Jun 2009
Publication timeframe
4 times per year
Languages
English
Cardioprotective activity of flax lignan concentrate extracted from seeds of <italic>Linum usitatissimum</italic> in isoprenalin induced myocardial necrosis in rats

The objective of the study was to evaluate the cardioprotective activity of flax lignan concentrate (FLC) in isoprenalin (ISO) induced cardiotoxicity in rats. Male Wistar rats (200-230 g) were divided into three groups. Group I: control, Group II: isoprenalin, Group III: FLC (500 mg/kg, p.o.) orally for 8 days and in group II and III isoprenalin 5.25 mg/kg, s.c. on day 9 and 8.5 mg/kg on day 10. On day 10 estimation of marker enzymes in serum and haemodynamic parameters were recorded. Animals were sacrificed, histology of heart was performed. Isoprenalin showed cardiotoxicity, manifested by increased levels of marker enzymes and increased heart rate. FLC treatment reversed these biochemical changes significantly compared with ISO group. The cardiotoxic effect of isoprenalin was less in FLC pretreated animals, which was confirmed in histopathological alterations. Haemodynamic, biochemical alteration and histopathological results suggest a cardioprotective protective effect of FLC in isoprenalin induced cardiotoxicity.

Keywords

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