The Association of Anxiety and Depression with the Quality of Life of People with Multiple Sclerosis

1 Neurological disorders: public health challenges. Geneva: World Health Organization, 2006. Search in Google Scholar

2 Nortvedt MW, Riise T, Myhr KM, Nyland HI. Quality of life in multiple sclerosis: measuring the disease effects more broadly. Neurology. 1999;53:1098-103. https://doi.org/10.1212/wnl.53.5.1098. Search in Google Scholar

3 Solari A, Radice D. Health status of people with multiple sclerosis: a community mail survey. Neurol Sci. 2001;22:307-15. https://doi.org/10.1007/s10072-001-8173-8 Search in Google Scholar

4 Janardhan V, Bakshi R. Quality of life and its relationship to brain lesions and atrophy on magnetic resonance images in 60 patients with multiple sclerosis. Arch Neurol. 2000;57:1485-91. https://doi.org/10.1001/archneur.57.10.1485. Search in Google Scholar

5 Burden of illness of multiple sclerosis: Part II: quality of life. The Canadian burden of illness study group. Can J Neurol Sci. 1998;25:31-8. Search in Google Scholar

6 Rothwell PM, McDowell Z, Wong CK, Dorman PJ. Doctors and patients don’t agree: cross sectional study of patients’ and doctors’ perceptions and assessments of disability in multiple sclerosis. BMJ. 1997;314:1580-3. https://doi.org/10.1136/bmj.314.7094.1580 Search in Google Scholar

7 Murphy N, Confavreux C, Haas J, Konig N, Roullet E, Sailer M, et al. Quality of life in multiple sclerosis in France, Germany, and the United Kingdom. J Neurol Neurosurg Psychiatry. 1998;65:460-6. Search in Google Scholar

8 Vickrey BG, Hays RD, Harooni R, Myers LW, Ellison GW. A health-related quality of life measure for multiple sclerosis. Qual Life Res. 1995;4:187–206. Search in Google Scholar

9 Kargarfarda M, Eetemadifarb M, Mehrabi M, Maghzi AH, Hayatbakhsh MR. Fatigue, depression, and healthrelated quality of life in patients with multiple sclerosis in Isfahan, Iran. Eur J Neurol. 2012;19:431-7. https://doi.org/10.1111/j.1468-1331.2011.03535.x Search in Google Scholar

10 Patti F, Pozzilli C, Montanari E, Pappalardo A, Piazza L, Levi A, et al. Effects of education level and employment status on HRQoL in early relapsing- emitting multiple sclerosis. Mult Scler. 2007;13:783–91. https://doi.org/10.1177/1352458506073511 Search in Google Scholar

11 Nedović G, Rapaić D, Odović G, Potić S, Milićević M. Socijalna participacija osoba sa invaliditetom. Beograd: Društvo defektologa Srbije, 2012. Search in Google Scholar

12 Medenica V, Ivanović L, Dragojlović-Ružičić R, Arsić-Komljenović G. Aktuelna shvatanja o multiploj sklerozi i mogućnosti procene invalidnosti kod obolelih osoba. Zdravstvena zaštita, 2011;40:7-12. Search in Google Scholar

13 Kaisey M, Solomon AJ, Luu M, Giesser BS, Sicotte NL. Incidence of multiple sclerosis misdiagnosis in referrals to two academic centers. Mult Scler Relat Disord. 2019;30:51-56. https://doi.org/10.1016/j.msard.2019.01.048 Search in Google Scholar

14 Silveira C, Guedes, R, Maia D, Curral R, Coelho R. Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art. Psychiatry Investig. 2019;16(12): 877–888. Search in Google Scholar

15 National Multiple Sclerosis Society, MS Symptoms. Available at https://www.nationalmssociety.org/Symptoms-Diagnosis/MSSymptoms. Accessed November 4, 2021. Search in Google Scholar

16 Rieckmann P, Centonze D, Elovaara I, Giovannoni G, Havrdová E, Kesselring J et al. Unmet needs, burden of treatment, and patient engagement in multiple sclerosis: A combined perspective from the MS in the 21st Century Steering Group. Mult Scler Relat Disord 2018;19:153-160. https://doi.org/10.1016/j.msard.2017.11.013 Search in Google Scholar

17 Radojičić B. Bolesti nervnog sistema. Beograd: Elit-Medicina, 1996. Search in Google Scholar

18 Sadovnick AD, Remick RA, Allen J, Swartz E, Yee IM, Eisen K, et al. Depression and multiple sclerosis. Neurology. 1996;46:628–32. https://doi.org/10.1212/wnl.46.3.628 Search in Google Scholar

19 Goretti B, Portaccio E, Zipoli V, Hakiki B, Siracusa G, Sorbi S, et al. Coping strategies, psychological variables and their relationship with quality of life in multiple sclerosis. Neurol Sci. 2009;30:15-20. https://doi.org/10.1007/s10072-008-0009-3 Search in Google Scholar

20 Siegert RJ, Abernethy DA. Depression in multiple sclerosis: a review. J Neurol Neurosurg Psychiatry. 2005;76:469-75. https://doi.org/10.1136/jnnp.2004.054635 Search in Google Scholar

21 Amato MP, Ponziani G, Rossi F, Liedl CL, Stefanile C, Rossi L. Quality of life in multiple sclerosis: the impact of depression, fatigue and disability. Mult Scler. 2001:7:340-4. https://doi.org/10.1177/135245850100700511 Search in Google Scholar

22 Korostil M, Feistein A. Anxiety disorders and their clinical correlates in multiple sclerosis patients. Mult Scler. 2007;13:67–72. https://doi.org/10.1177/1352458506071161 Search in Google Scholar

23 Janssens ACJW, van Doorn PA, de Boer JB, van der Meche FGA, Passchier J, Hintzen RQ. Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners. Acta Neurol Scand. 2003;108:389–95. https://doi.org/10.1034/j.1600-0404.2003.00166.x Search in Google Scholar

24 Beiske AG, Svensson E, Sandanger I, Czujko B, Pedersen ED, Aarseth JH, et al. Depression and anxiety amongst multiple sclerosis patients. Eur J Neurol. 2008;15:239-45. https://doi.org/10.1111/j.1468-1331.2007.02041.x Search in Google Scholar

25 Benedict RH, Wahlig E, Bakshi R, Fishman I, Munschauer F, Zivadinov R, et al. Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behaviour change. J Neurol Sci. 2005;231:29–34. https://doi.org/10.1016/j.jns.2004.12.009 Search in Google Scholar

26 Merkelbach S, Sittinger H, Koenig J. Is there a differential impact of fatigue and physical disability on quality of life in multiple sclerosis? J Nerv Ment Dis. 2002;190:388–93. https://doi.org/10.1097/00005053-200206000-00007 Search in Google Scholar

27 Janssens AC, van Doorn PA, de Boer JB, Kalkers NF, van der Meche FG, Passchier J, et al. Anxiety and depression influence the relation between disability status and quality of life in multiple sclerosis. Mult Scler. 2003;9:397–403. https://doi.org/10.1191/1352458503ms930oa Search in Google Scholar

28 Fruehwald S, Loeffler-Stastka H, Eher R, Saletu B, Baumhackl U. Depression and quality of life in multiple sclerosis. Acta Neurol Scand. 2001;104:257–61. https://doi.org/10.1034/j.1600-0404.2001.00022.x. Search in Google Scholar

29 Lee CH, Giuliani F. The Role of Inflammation in Depression and Fatigue. Front Immunol. 2019;10:1696. https://doi.org/10.3389/fimmu.2019.01696 Search in Google Scholar

30 Nygaard GO, Walhovd KB, Sowa P, Chepkoech JL, Bjørnerud A, Due-Tønnessen P, Landrø NI, Damangir S, Spulber G, Storsve AB, Beyer MK, Fjell AM, Celius EG, Harbo HF. Cortical thickness and surface area relate to specific symptoms in early relapsing-remitting multiple sclerosis. Mult Scler. 2015:21(4):402-14. https://doi.org/10.1177/1352458514543811 Search in Google Scholar

31 Patejdl R, Penner IK, Noack TK, Zettl UK. Multiple sclerosis and fatigue: A review on the contribution of inflammation and immune-mediated neurodegeneration. Autoimmun Rev. 2016;15(3):210-20. https://doi.org/10.1016/j.autrev.2015.11.005 Search in Google Scholar

32 Hurley LL, Tizabi Y. Neuroinflammation, neurodegeneration, and depression. Neurotox Res. 2013;23(2):131-44. https://doi.org/10.1007/s12640-012-9348-1 Search in Google Scholar

33 Nedeljković U. Effect of rehabilitation on recovery of persons with multiple sclerosis after relapse of disease: doctoral thesis. Belgrade: University of Belgrade, School of Medicine, 2014. Search in Google Scholar

34 Beck AT, Steer RA, Brown GK. Beck depression inventory (2nd ed. manual). San Antonio, TX: Psychological Corporation, 1996. Search in Google Scholar

35 Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-71. https://doi.org/10.1001/archpsyc.1961.01710120031004 Search in Google Scholar

36 Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Manual for the State-Trait Anxiety Inventory for adults. Palo Alto, CA: Consulting Psychologists Press, 1983. Search in Google Scholar

37 Pekmezovic T, Kisic Tepavcevic D, Kostic J, Drulovic J. Validation and cross-cultural adaptation of the disease-specific questionnaire MSQOL-54 in Serbian multiple sclerosis patients sample. Qual Life Res 2007;16:1383-7. Search in Google Scholar

38 Salehpoor GH, Kafi SM, Rezaei S, Hosseininezhad M, Salehi I. The relation between fatigue severity with psychological symptoms and quality of life in multiple sclerosis. Zahedan J Res Med Sci. 2012;14:80–6. Search in Google Scholar

39 Göksel Karatepe A, Kaya T, Günaydn R, Demirhan A, Ce P, Gedizlioğlu M. Quality of life in patients with multiple sclerosis: the impact of depression, fatigue, and disability. Int J Rehabil Res. 2011;34:290–8. https://doi.org/10.1097/MRR.0b013e32834ad479 Search in Google Scholar

40 Patti F, Cacopardo M, Palermo F, Ciancio MR, Lopes R, Restivo D, et al. Health-related quality of life and depression in an Italian sample of multiple sclerosis patients. J Neurol Sci. 2003;211:55–62. https://doi.org/10.1016/s0022-510x(03)00040-6 Search in Google Scholar

41 Stenager E, Knudsen L, Jensen K. Multiple sclerosis: correlation of anxiety, physical impairment and cognitive dysfunction. Ital J Neurol Sci. 1994;15:97–101. https://doi.org/10.1007/bf02340120 Search in Google Scholar

42 Janardhan V, Bakshi R. Quality of life in patients with multiple sclerosis: The impact of fatigue and depression. J Neurol Sci. 2002;205:51–8. https://doi.org/10.1016/s0022-510x(02)00312-x Search in Google Scholar

43 Patti F, Russo P, Pappalardo A, Macchia F, Civalleri L, Paolillo A. Predictors of quality of life among patients with multiple sclerosis: An Italian cross-sectional study. J Neurol Sci. 2007;252:121–9. https://doi.org/10.1016/j.jns.2006.10.017 Search in Google Scholar

44 Santos M, Sousa C, Pereira M, Pereira MG. Quality of life in patients with multiple sclerosis: a study with patients and caregivers. Disabil Health J. 2019;12:628-34. https://doi.org/10.1016/j.dhjo.2019.03.007 Search in Google Scholar

45 Salehpoor G, Rezaei S, Hosseininezhad M. Quality of life in multiple sclerosis (MS) and role of fatigue, depression, anxiety, and stress: a bicenter study from north of Iran. Iran J Nurs Midwifery Res. 2014;19:593–9. Search in Google Scholar

46 Ashjazadeh N, Hadianfard H, Feridoni S, Farjam E. Assessment of health-related quality of life in patients with multiple sclerosis living in the Fars province of Iran. Neuroimmunol Neuroinflamm. 2016;3:57-62 http://doi.org/10.20517/2347-8659.2015.40 Search in Google Scholar

47 Rothwell PM, McDowel Z, Wong CK, Dorman PJ. Doctors and patients don’t agree: cross sectional study of patients’ and doctors’ perceptions and assessments of disability in multiple sclerosis. BMJ. 1997;314:1580-3 Search in Google Scholar

48 Fernández-Jiménez E, Arnett PA. Impact of neurological impairment, depression, cognitive function and coping on quality of life of people with multiple sclerosis: A relative importance analysis. Mult Scler. 2015;21(11): 1468-1472. https://doi.org/10.1177/1352458514562439 Search in Google Scholar

49 Spain LA, Tubridy N, Kilpatrick TJ, et al. Illness perception and health-related quality of life in multiple sclerosis. Acta Neurol Scand 2007; 116:293–299. Search in Google Scholar

50 McKay KA, Tremlett H, Fisk JD, et al. Psychiatric comorbidity is associated with disability progression in multiple sclerosis. Neurology. 2018;90(15):e1316–e1323. Search in Google Scholar

51 Brajković L, Braš M, Milunović V, Bušić I, Boban M, Lončar B, et al. The connection between coping mechanisms, depression, anxiety and fatigue in multiple sclerosis. Coll Antropol. 2009;33(Suppl. 2):135–40. Search in Google Scholar

52 D’Alisa S, Miscio G, Baudo S, Simone A, Tesio L, Mauro A. Depression is the main determinant of quality of life in multiple sclerosis: a classification-regression (CART) study. Disabil Rehabil. 2006;28:307-14. https://doi.org/10.1080/09638280500191753 Search in Google Scholar

53 Mao P, Reddy PH. Is multiple sclerosis a mitochondrial disease? Biochim Biophys Acta. 2010;1802:66–79. https://doi.org/10.1016/j.bbadis.2009.07.002 Search in Google Scholar

54 Foley FW, Traugott U, LaRocca NG, Smith CR, Perlman KR, Caruso LS, Scheinberg LC. A prospective study of depression and immune dysregulation in multiple sclerosis. Arch Neurol. 1992;49(3):238-44. Search in Google Scholar

55 Gold SM, Irwin MR. Depression and Immunity: Inflammation and Depressive Symptoms in Multiple Sclerosis. Neurol Clin. 2006;24:507–519. Search in Google Scholar

56 Berrigan LI, Fisk JD, Patten S, Tremlett H, Wolfson C, Warren S, et al. Health-related quality of life in multiple sclerosis: direct and indirect effects of comorbidity. Neurology. 2016; 86:1417-24. https://doi.org/10.1212/WNL.0000000000002564 Search in Google Scholar