Gingival Enlargement Caused by Calcium Channel Blockers

1. Gopal S, Joseph R, Santhosh VC, Kumar VV, Joseph S, Shete AR. Prevalence of gingival overgrowth induced by antihypertensive drugs: A hospital-based study. J Indian Soc Periodontol. 2015;19(3):308-11.10.4103/0972-124X.153483452011726229273 Search in Google Scholar

2. Trackman PC, Kantarci A. Molecular and clinical aspects of drug-induced gingival overgrowth. J Dent Res. 2015; 94 (4): 540-546.10.1177/0022034515571265448521725680368 Search in Google Scholar

3. Goriuc A, Foia LG, Minea B, Luchian AI, Surdu AE, Toma V, Costuleanu M, Mârţu I. Drug-induced gingival hyperplasia - experimental model. Rom J Morphol Embryol. 2017; 58 (4): 1371-1376. Search in Google Scholar

4. Dongari-Bagtzoglou A; Research, Science and Therapy Committee, American Academy of Periodontology. Drug-associated gingival enlargement. J Periodontol. 2004;75(10):1424-31.10.1902/jop.2004.75.10.142429539069 Search in Google Scholar

5. Tonsekar P, Tonsekar V. Calcium-Channel-Blocker- Influenced Gingival Enlargement: A Conundrum Demystified. Oral. 2021;1(3):236-49.10.3390/oral1030023 Search in Google Scholar

6. Seymour RA, Jacobs DJ. Cyclosporin and the gingival tissues. J Clin Perio. 1992; 19: 1–11.10.1111/j.1600-051X.1992.tb01140.x1732303 Search in Google Scholar

7. Tamargo J, Ruilope LM. Investigational calcium channel blockers for the treatment of hypertension. Expert Opin Investig Drugs. 2016;25(11):1295-1309.10.1080/13543784.2016.124176427696904 Search in Google Scholar

8. McKeever RG, Hamilton RJ. Calcium Channel Blockers. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. Search in Google Scholar

9. Lin Y, Ma L. Blood pressure lowering effect of calcium channel blockers on perioperative hypertension: A systematic review and meta-analysis. Medicine (Baltimore). 2018;97(48):e13152.10.1097/MD.0000000000013152628318730508892 Search in Google Scholar

10. Wang AL, Iadecola C, Wang G. New generations of dihydropyridines for treatment of hypertension. J Geriatr Cardiol. 2017;14(1):67-72. Search in Google Scholar

11. Volpe M. Calcium Channel Blockers for the Clinical Management of Hypertension. High Blood Press Cardiovasc Prev. 2018;25(1):1-3.10.1007/s40292-017-0233-029022231 Search in Google Scholar

12. Wing LMH. Calcium channel antagonists. Aust Prescr 1997;20:5-8.10.18773/austprescr.1997.004 Search in Google Scholar

13. Russell RP. Side effects of calcium channel blockers. Hypertension. 1988;11(3 Pt 2):II42-4.10.1161/01.HYP.11.3_Pt_2.II423280492 Search in Google Scholar

14. Dustan HP. Calcium channel blockers. Potential medical benefits and side effects. Hypertension. 1989;13(5 Suppl):I137-4010.1161/01.HYP.13.5_Suppl.I137 Search in Google Scholar

15. Bharti V, Bansal C. Drug-induced gingival overgrowth: The nemesis of gingiva unravelled. J Indian Soc Periodontol. 2013; 17 (2): 182-187.10.4103/0972-124X.113066371374823869123 Search in Google Scholar

16. Tungare S, Paranjpe AG. Drug Induced Gingival Overgrowt. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. Search in Google Scholar

17. Tahamtan S, Shirban F, Bagherniya M, Johnston TP, Sahebkar A. The effects of statins on dental and oral health: A review of preclinical and clinical studies. J Transl Med. 2020; 18: 1–42.10.1186/s12967-020-02326-8713295532252793 Search in Google Scholar

18. Quach H, Ray-Chaudhuri A. Calcium channel blocker induced gingival enlargement following implant placement in a fibula free flap reconstruction of the mandible: A case report. Int J Implant Dent. 2020; 6: 1–5.10.1186/s40729-020-00242-6743148332808200 Search in Google Scholar

19. Asif SM, Shaik N, Barthunia B, Kaleem SM, Zakirulla M, Kota MZ, Baig FAH. Nifedipine induced gingival enlargement in an edentulous patient: a case report with one year follow up. BMC Oral Health. 2018;18(1):227.10.1186/s12903-018-0690-4630715730587167 Search in Google Scholar

20. Casetta I, Granieri E, Desiderá M, Monetti VC, Tola MR, Paolino E, Govoni V, Calura G. Phenytoin-induced gingival overgrowth: a community-based cross-sectional study in Ferrara, Italy. Neuroepidemiology. 1997;16(6):296-303.10.1159/0001097009430129 Search in Google Scholar

21. Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. J Periodontol. 1999;70(1):63-7.10.1902/jop.1999.70.1.6310052772 Search in Google Scholar

22. Barclay S, Thomason JM, Idle JR, Seymour RA. The incidence and severity of nifedipine-induced gingival overgrowth. J Clin Periodontol. 1992;19(5):311-4.10.1111/j.1600-051X.1992.tb00650.x Search in Google Scholar

23. Fattore L, Stablein M, Bredfeldt G, Semla T, Moran M, Doherty-Greenberg JM. Gingival hyperplasia: a side effect of nifedipine and diltiazem. Spec Care Dentist. 1991;11(3):107-9.10.1111/j.1754-4505.1991.tb00828.x1887359 Search in Google Scholar

24. Nery EB, Edson RG, Lee KK, Pruthi VK, Watson J. Prevalence of nifedipine-induced gingival hyperplasia. J Periodontol. 1995;66(7):572-8.10.1902/jop.1995.66.7.5727562349 Search in Google Scholar

25. Bajkovec L, Mrzljak A, Likic R, Alajbeg I. Drug-induced gingival overgrowth in cardiovascular patients. World J Cardiol. 2021;13(4):68-75.10.4330/wjc.v13.i4.68806952133968305 Search in Google Scholar

26. Ishida H, Kondoh T, Kataoka M, Nishikawa S, Nakagawa T, Morisaki I, Kido J, Oka T, Nagata T. Factors influencing nifedipine-induced gingival overgrowth in rats. J Periodontol. 1995;66(5):345-50.10.1902/jop.1995.66.5.3457623253 Search in Google Scholar

27. Seymour RA, Ellis JS, Thomason JM. Risk factors for drug-induced gingival overgrowth. J Clin Periodontol. 2000;27(4):217-23.10.1034/j.1600-051x.2000.027004217.x10783833 Search in Google Scholar

28. Pasupuleti MK, Musalaiah SV, Nagasree M, Kumar PA. Combination of inflammatory and amlodipine induced gingival overgrowth in a patient with cardiovascular disease. Avicenna J Med. 2013;3(3):68-72.10.4103/2231-0770.118462381878224251234 Search in Google Scholar

29. Seymour RA, Heasman PA. Drugs and the periodontium. J Clin Periodontol. 1988;15(1):1-16.10.1111/j.1600-051X.1988.tb01549.x3276739 Search in Google Scholar

30. Seymour RA, Jacobs DJ. Cyclosporin and the gingival tissues. J Clin Periodontol. 1992;19(1):1-11.10.1111/j.1600-051X.1992.tb01140.x1732303 Search in Google Scholar

31. Aldemir NM, Begenik H, Emre H, Erdur FM, Soyoral Y. Amlodipine-induced gingival hyperplasia in chronic renal failure: a case report. Afr Health Sci. 2012;12(4):576-8. Search in Google Scholar

32. Tejnani A, Gandevivala A, Bhanushali D, Gourkhede S. Combined treatment for a combined enlargement. J Indian Soc Periodontol. 2014;18(4):516-9.10.4103/0972-124X.138747415859825210271 Search in Google Scholar

33. Gaur S, Agnihotri R. Is dental plaque the only etiological factor in Amlodipine induced gingival overgrowth? A systematic review of evidence. J Clin Exp Dent. 2018;10(6):e610-e61910.4317/jced.54715600509429930781 Search in Google Scholar

34. Takeuchi RE, Matsumoto HI, Akimoto YO, Fujii AK. The inhibitory action of amlodipine for TNF-α-induced apoptosis in cultured human gingival fibroblasts. Oral Ther. Pharmacol. 2012;31:45-52. Search in Google Scholar

35. Livada R, Shiloah J. Calcium channel blocker-induced gingival enlargement. J Hum Hypertens. 2014;28(1):10-4.10.1038/jhh.2013.4723739159 Search in Google Scholar

36. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999;4(1):1-6.10.1902/annals.1999.4.1.110863370 Search in Google Scholar

37. Daley TD, Wysocki GP. Cyclosporine therapy. Its significance to the periodontist. J Periodontol. 1984;55(12):708-12.10.1902/jop.1984.55.12.7086335173 Search in Google Scholar

38. Ellis JS, Monkman SC, Seymour RA, Idle JR. Determination of nifedipine in gingival crevicular fluid: a capillary gas chromatographic method for nifedipine in microlitre volumes of biological fluid. J Chromatogr. 1993;621(1):95-10110.1016/0378-4347(93)80081-E8308093 Search in Google Scholar

39. Bharti V, Bansal C. Drug-induced gingival overgrowth: The nemesis of gingiva unravelled. J Indian Soc Periodontol. 2013;17(2):182-7.10.4103/0972-124X.113066371374823869123 Search in Google Scholar

40. Meisel P, Giebel J, Kunert-Keil C, Dazert P, Kroemer HK, Kocher T. MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists. Clin Pharmacol Ther. 2006;79(1):62-71.10.1016/j.clpt.2005.09.00816413242 Search in Google Scholar

41. Uzel MI, Kantarci A, Hong HH, Uygur C, Sheff MC, Firatli E, Trackman PC. Connective tissue growth factor in drug-induced gingival overgrowth. J Periodontol. 2001;72(7):921–931.10.1902/jop.2001.72.7.92111495141 Search in Google Scholar

42. Lucas RM, Howell LP, Wall BA. Nifedipine-induced gingival hyperplasia. A histochemical and ultrastructural study. J Periodontol 1985; 56(4):211–215.10.1902/jop.1985.56.4.2113858503 Search in Google Scholar

43. Ramírez-Rámiz A, Brunet-LLobet L, Lahor-Soler E, Miranda-Rius J. On the Cellular and Molecular Mechanisms of Drug-Induced Gingival Overgrowth. Open Dent J. 2017;11:420-435.10.2174/1874210601711010420556401628868093 Search in Google Scholar

44. Castro LA, Elias LS, Oton-Leite AF, de Spíndula-Filho JV, Leles CR, Batista AC, Mendonça EF. Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study. J Oral Sci. 2010;52(1):55-62.10.2334/josnusd.52.5520339233 Search in Google Scholar

45. Brown RS, Arany PR. Mechanism of drug-induced gingival overgrowth revisited: a unifying hypothesis. Oral Dis. 2015;21(1):e51-61.10.1111/odi.12264524188824893951 Search in Google Scholar

46. Thomason JM, Seymour RA, Ellis JS, Kelly PJ, Parry G, Dark J, Wilkinson R, Ilde JR. Determinants of gingival overgrowth severity in organ transplant patients. An examination of the rôle of HLA phenotype. J Clin Periodontol. 1996;23(7):628-34.10.1111/j.1600-051X.1996.tb00586.x Search in Google Scholar

47. Pernu HE, Knuuttila ML. Macrophages and lymphocyte subpopulations in nifedipine and cyclosporin A associated human gingival overgrowth. J Periodontol 2001;72(2):160-6.10.1902/jop.2001.72.2.16011288788 Search in Google Scholar

48. Nurmenniemi PK, Pernu HE, Laukkanen P, Knuuttila ML. Macrophage subpopulations in gingival overgrowth induced by nifedipine and immunosuppressive medication. J Periodontol 2002;73(11):1323-30.10.1902/jop.2002.73.11.132312479637 Search in Google Scholar

49. Duncan MR, Berman B. Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fifibroblasts by recombinant human interleukin- 6. J Invest Dermatol 1991; 97: 686–689.10.1111/1523-1747.ep124839711940439 Search in Google Scholar

50. Csiszar A, Wiebe C, Larjava H, Häkkinen L. Distinctive molecular composition of human gingival interdental papilla. J Periodontol 2007;78(2): 304-14.10.1902/jop.2007.06016517274720 Search in Google Scholar

51. Walsh P, Häkkinen L, Pernu H, Knuuttila M, Larjava H. Expression of fibronectin-binding integrins in gingival epithelium in drug-induced gingival overgrowth. J Periodontal Res 2007; 42(2): 144-51.10.1111/j.1600-0765.2006.00927.x17305873 Search in Google Scholar

52. Lu HK, Tseng CC, Lee YH, Li CL, Wang LF. Flutamide inhibits nifedipine- and interleukin-1 beta induced collagen overproduction in gingival fibroblasts. J Periodontal Res 2010; 45: 451-457.10.1111/j.1600-0765.2009.01255.x Search in Google Scholar

53. Sooriyamoorthy M, Gower DB, Eley BM. Androgen metabolism in gingival hyperplasia induced by nifedipine and cyclosporin. J Periodont Res 1990; 25(1): 25-30.10.1111/j.1600-0765.1990.tb01204.x2137169 Search in Google Scholar

54. Steele RM, Schuna AA, SchreiberRT. Calcium antagonist- induced gingival hyperplasia. Ann Intern Med 1994;120:663-4.10.7326/0003-4819-120-8-199404150-000068135450 Search in Google Scholar

55. Chin YT, Tu HP, Lin CY, Kuo PJ, Chiu HC, Liu SH, Lee SY, Fu E. Antioxidants protect against gingival overgrowth induced by cyclosporine A. J Periodontal Res. 2021;56(2):397-407.10.1111/jre.1283233448057 Search in Google Scholar

56. Miranda J, Brunet L, Roset P, Farré M, Mendieta C. Reliability of two measurement indices for gingival enlargement. J Periodontal Res. 2012;47(6):776-82.10.1111/j.1600-0765.2012.01495.x22897219 Search in Google Scholar

57. Marshall RI, Bartold PM. A clinical review of druginduced gingival overgrowths. Aust Dent J. 1999;44(4):219-32.10.1111/j.1834-7819.1999.tb00224.x10687229 Search in Google Scholar

58. Lafzi A, Farahani RM, Shoja MA. Amlodipine-induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal. 2006;11(6):E480-2. Search in Google Scholar

59. Aldemir NM, Begenik H, Emre H, Erdur FM, Soyoral Y. Amlodipine-induced gingival hyperplasia in chronic renal failure: a case report. Afr Health Sci. 2012;12(4):576-8.10.4314/ahs.v12i4.30 Search in Google Scholar

60. Torpet LA, Kragelund C, Reibel J, Nauntofte B. Oral adverse drug reactions to cardiovascular drugs. Critical reviews in oral biology & medicine. 2004;15(1):28-46.10.1177/15441113040150010414761898 Search in Google Scholar

61. Quenel L, Keribin P, Giran G, Tessier MH, Lesclous P. Amlodipine-induced gingival enlargement: A case report. J Stomatol Oral Maxillofac Surg. 2020;121(3):308-311.10.1016/j.jormas.2019.04.01431055091 Search in Google Scholar

62. Camargo PM, Melnick PR, Pirih FQ, Lagos R, Takei HH. Treatment of drug-induced gingival enlargement: aesthetic and functional considerations. Periodontol 2000. 2001;27:131-8.10.1034/j.1600-0757.2001.027001131.x11551304 Search in Google Scholar

63. Harel-Raviv M, Eckler M, Lalani K, Raviv E, Gornitsky M. Nifedipine-induced gingival hyperplasia. A comprehensive review and analysis. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 1995;79(6):715-22.10.1016/S1079-2104(05)80306-3 Search in Google Scholar

64. Hall EE. Prevention and treatment considerations in patients with drug-induced gingival enlargement. Curr Opin Periodontol. 1997;4:59-63. Search in Google Scholar

65. Thompson AL, Herman WW, Konzelman J, Collins MA. Treating patients with drug-induced gingival overgrowth. J Dent Hyg. 2004;78(4):12. Search in Google Scholar

66. Dannewitz B, Krieger JK, Simon I, Dreyhaupt J, Staehle HJ, Eickholz P. Full-mouth disinfection as a nonsurgical treatment approach for drug-induced gingival overgrowth: a series of 11 cases. Int J Periodontics Restorative Dent. 2010;30(1):63-71. Search in Google Scholar

67. Dongari A, McDonnell HT, Langlais RP. Drug-induced gingival overgrowth. Oral Surg Oral Med Oral Pathol. 1993;76(4):543-8.10.1016/0030-4220(93)90027-28233439 Search in Google Scholar

68. Pejčić AS, Kesić LG, Živković VD, Obradović RR, Petrović MS, Mirković DS. Gingival overgrowth induced by nifedipine: Gingiva and drugs. Acta stomatologica Naissi. 2011;27(64):1104-9.10.5937/asn1164104P Search in Google Scholar

69. Mavrogiannis M, Ellis JS, Seymour RA, Thomason JM. The efficacy of three different surgical techniques in the management of drug-induced gingival overgrowth. J Clin Periodontol. 2006;33(9):677-82.10.1111/j.1600-051X.2006.00968.x16856895 Search in Google Scholar

70. Ilgenli T, Atilla G, Baylas H. Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results. J Periodontol. 1999;70(9):967-72.10.1902/jop.1999.70.9.96710505798 Search in Google Scholar

71. Ciancio SG, Bartz NW Jr, Lauciello FR. Cyclosporineinduced gingival hyperplasia and chlorhexidine: a case report. Int J Periodontics Restorative Dent. 1991;11(3):241-5. Search in Google Scholar

72. Alims.gov.rs. 2021. ALIMS. [online] Available at: <https://www.alims.gov.rs/> [Accessed 22 September 2021]. Search in Google Scholar

73. Ustaoğlu G, Erdal E, Karaş Z. Influence of different antihypertensive drugs on gingival overgrowth: A crosssectional study in a Turkish population. Oral Dis. 2021;27(5):1313-9.10.1111/odi.1365532991012 Search in Google Scholar