<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Calcium channel blockers, a group of drugs widely used in the treatment of cardiovascular patients, although effective, often cause gingival enlargement, a side effect that is rarely recognized in clinical practice and is not given sufficient importance. Gingival enlargement caused by calcium channel blockers can be localized or generalized, mild or severe. It can negatively affect patients’ appearance, mastication, and speech, thus considerably reducing the quality of life of patients. Risk factors and pathogenesis of this side effect have been the subject of many studies but are still unknown, making this condition a major therapeutic challenge, especially if the cessation of the offending drug is not possible. This study aimed to review the etiology, potential risk factors, pathogenesis, clinical features, and therapy possibilities for gingival enlargement caused by calcium channel blockers.</p>
</abstract>

Calcium channel blockers, a group of drugs widely used in the treatment of cardiovascular patients, although effective, often cause gingival enlargement, a side effect that is rarely recognized in clinical practice and is not given sufficient importance. Gingival enlargement caused by calcium channel blockers can be localized or generalized, mild or severe. It can negatively affect patients’ appearance, mastication, and speech, thus considerably reducing the quality of life of patients. Risk factors and pathogenesis of this side effect have been the subject of many studies but are still unknown, making this condition a major therapeutic challenge, especially if the cessation of the offending drug is not possible. This study aimed to review the etiology, potential risk factors, pathogenesis, clinical features, and therapy possibilities for gingival enlargement caused by calcium channel blockers.

Gingival Enlargement Caused by Calcium Channel Blockers

Department of Dentistry, Faculty of Medical Sciences

Department of Physiology, Faculty of Medical Sciences

Department of Pharmacology and Toxicology, Faculty of Medical Sciences

Department of Histology and Embryology, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Gingival Enlargement Caused by Calcium Channel Blockers"}

Calcium channel blockers, a group of drugs widely used in the treatment of cardiovascular patients, although effective, often cause gingival enlargement, a...

Gingival Enlargement Caused by Calcium Channel Blockers

Published Online: Dec 31, 2022

Page range: -

Received: Sep 28, 2021

Accepted: Oct 28, 2021

DOI: https://doi.org/10.2478/sjecr-2021-0061

Keywords
Drug-induced gingival enlargement, calcium channel blockers, oral adverse effects

© 2022 Jana Desnica et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Gingival Enlargement Caused by Calcium Channel Blockers

Published Online: Dec 31, 2022

Page range: -

Received: Sep 28, 2021

Accepted: Oct 28, 2021

DOI: https://doi.org/10.2478/sjecr-2021-0061

KeywordsDrug-induced gingival enlargement, calcium channel blockers, oral adverse effects

© 2022 Jana Desnica et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Drug-induced gingival enlargement, calcium channel blockers, oral adverse effects