<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Periodontal diseases involve several conditions that are defined by pathologic loss of the periodontal ligament and alveolar bone. Periodontitis is an inflammatory disease of periodontal tissue caused by a host immune response to dysbiotic microbial biofilm whose progression associated with destruction of tooth supporting tissue is promoted by host proteinases. Periradicular periodontitis is the most commonly diagnosed disease that affects the pathology of periodontal tissue in the area of the tooth root. This disease has also been described as apical periodontitis. Several experimental models of periodontal diseases have been developed in recent years. This paper provides an overview of experimentally induced animal models of periodontal disease (periodontitis and periradicular periodontitis) and the possibility of using different experimental animals to study aspects of periodontal disease, each with advantages and disadvantage.</p>
</abstract>

Periodontal diseases involve several conditions that are defined by pathologic loss of the periodontal ligament and alveolar bone. Periodontitis is an inflammatory disease of periodontal tissue caused by a host immune response to dysbiotic microbial biofilm whose progression associated with destruction of tooth supporting tissue is promoted by host proteinases. Periradicular periodontitis is the most commonly diagnosed disease that affects the pathology of periodontal tissue in the area of the tooth root. This disease has also been described as apical periodontitis. Several experimental models of periodontal diseases have been developed in recent years. This paper provides an overview of experimentally induced animal models of periodontal disease (periodontitis and periradicular periodontitis) and the possibility of using different experimental animals to study aspects of periodontal disease, each with advantages and disadvantage.

Experimental Animal Models of Periodontal Diseases

University of Kragujevac, Faculty of Medical Sciences

Department of Histology and Embriology, Faculty of Medical Sciences

Department of Pharmacy, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Experimental Animal Models of Periodontal Diseases"}

Periodontal diseases involve several conditions that are defined by pathologic loss of the periodontal ligament and alveolar bone. Periodontitis is an...

Experimental Animal Models of Periodontal Diseases

Published Online: May 01, 2024

Page range: -

DOI: https://doi.org/10.2478/sjecr-2021-0019

Keywords
Periodontal diseases, periodontitis, periradicular periodontitis, experimental model, animals

© 2021 Milica Velickovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Experimental Animal Models of Periodontal Diseases

Published Online: May 01, 2024

Page range: -

DOI: https://doi.org/10.2478/sjecr-2021-0019

KeywordsPeriodontal diseases, periodontitis, periradicular periodontitis, experimental model, animals

© 2021 Milica Velickovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Periodontal diseases, periodontitis, periradicular periodontitis, experimental model, animals