1. bookVolume 44 (2007): Issue 1 (March 2007)
Journal Details
License
Format
Journal
eISSN
1336-9083
ISSN
0440-6605
First Published
22 Apr 2006
Publication timeframe
4 times per year
Languages
English
access type Open Access

Effect of dimethylmaleate and phorone on glutathione content of Setaria cervi (Nematoda: Filarioidea) during in vitro incubation

Published Online: 01 Mar 2007
Volume & Issue: Volume 44 (2007) - Issue 1 (March 2007)
Page range: 14 - 17
Journal Details
License
Format
Journal
eISSN
1336-9083
ISSN
0440-6605
First Published
22 Apr 2006
Publication timeframe
4 times per year
Languages
English
Abstract

Glutathione metabolism represents a prospective target for antifilarial drug design, and therefore, the alterations in glutathione (GSH) content of filarial worms by known mammalian GSH depletors i.e. dimethylmaleate (DMM) and phorone were first thought for investigation in model filarial worms Setaria cervi. The dose dependent GSH depletion was achieved when these worms were incubated at 37°C for 6 h in Hanks balanced salt solution with varying concentrations (10–250 μM) of DMM or phorone. During the short incubation period of 6 h, 250 μM of DMM and phorone declined more than 90 % of the GSH content of filarial worms.

Keywords

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