1. bookVolume 26 (2018): Issue 3 (July 2018)
Journal Details
License
Format
Journal
eISSN
2284-5623
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English
Open Access

Association between MDR1 gene polymorphism and clinical course of pediatric pulmonary arterial hypertension

Published Online: 31 Jul 2018
Volume & Issue: Volume 26 (2018) - Issue 3 (July 2018)
Page range: 305 - 312
Received: 06 May 2018
Accepted: 05 Jul 2018
Journal Details
License
Format
Journal
eISSN
2284-5623
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English

1. Bazan IS, Fares WH. Pulmonary hypertension: diagnosis and therapeutic challenges. Ther Clin Risk Manag. 2015 Aug 17;11:1221-33.10.2147/TCRM.S74881454462826316767Search in Google Scholar

2. Crosswhite P, Sun Z. Nitric Oxide, oxidative stress and inflammation in pulmonary arterial hypertension. J Hipertens. 2010; 28(2):201-12. DOI: 10.1097/HJH.0b013e328332bcdb10.1097/HJH.0b013e328332bcdb280914020051913Open DOISearch in Google Scholar

3. Ghasemzadeh N, Patel RS, Eapen DJ, Veledar E, Kassem HA, Manocha P, et al. Oxidative stress is associated with increased pulmonary artery systolic pressure in humans. Hypertension. 2014 Jun;63(6):1270-5. DOI: 10.1161/HYPERTENSIONAHA.113.0236010.1161/HYPERTENSIONAHA.113.02360413853524614216Open DOISearch in Google Scholar

4. Sanders KA, Hoidal JR. The NOX on pulmonary hypertension. Circ Res. 2007; 101:224-6. DOI: 10.1161/CIRCRESAHA.107.15824610.1161/CIRCRESAHA.107.15824617673680Open DOISearch in Google Scholar

5. Fulton DJR, Li X, Bordan Zs, Haigh S, Bentley A, Chen F, et al. Reactive Oxygen and Nitrogen Species in the Development of Pulmonary Hypertension. Antioxidants (Basel). 2017; 6(3):54. DOI: 10.3390/antiox603005410.3390/antiox6030054561808228684719Open DOISearch in Google Scholar

6. McLaughlin VV, Gaine SP, Haward LS, Leuchte HH, Mathier MA, Mehta S, et al. Treatment goals of pulmonary hypertension. JACC. 2013; 24:62(25 Suppl):D73-81.10.1016/j.jacc.2013.10.03424355644Search in Google Scholar

7. Humbert M, Lau EMT, Montani D, Jais X, Sitbon O, Simonneau G. Advances in therapeutic interventions for patients with pulmonary arterial hypertension. Circulation. 2014; 130:2189-208. DOI: 10.1161/CIRCULATIONAHA.114.00697410.1161/CIRCULATIONAHA.114.00697425602947Open DOISearch in Google Scholar

8. Fares WH, Trow TK. Targeted approaches to the treatment of pulmonary hypertension. Ther Adv Respir Dis. 2012; 6:147-59. DOI: 10.1177/175346581244184910.1177/175346581244184922438264Search in Google Scholar

9. Austin ED, Loyd JE. The genetics of pulmonary arterial hypertension. Circ Res. 2014; 115(1):189-202. DOI: 10.1161/CIRCRESAHA.115.30340410.1161/CIRCRESAHA.115.303404413741324951767Open DOISearch in Google Scholar

10. Muntean I, Togănel R, Benedek T. Genetics of congenital heart disease: past and present. Biochem Genet. 2017; 55(2):105-23. DOI: 10.1007/s10528-016-9780-710.1007/s10528-016-9780-727807680Search in Google Scholar

11. Girerd B, Montani D, Coulet F, Sztrymf B, Yaici A, Jaïs X, et al. Clinical outcomes of pulmonary arterial hyper-tension in patients carrying an ACVRL1 (ALK1) mutation. Am J Respir Crit Care Med. 2010; 181(8):851-61. DOI: 10.1164/rccm.200908-1284OC10.1164/rccm.200908-1284OC20056902Search in Google Scholar

12. Girerd B, Weatherald J, Montani D, Humbert M. Heritable pulmonary hypertension: from bench to bedside. Eur Respir Rev. 2017;26(145):170037. DOI: 10.1183/16000617.0037-201710.1183/16000617.0037-201728877973Search in Google Scholar

13. Pânzaru M, Rusu C, Voloşciuc M, Braha E, Butnariu L, Gramescu M, et al. Benefits of cytogenetic testing in diagnosis of plurimalformative syndromes with congenital heart defects. Rev Romana Med Lab. 2012;20(3):265-72.Search in Google Scholar

14. Togănel R, Muntean I, Duicu C, Făgărăşan A, Gozar L, Bănescu C. The role of eNOS and AGT gene polymorphisms in secondary pulmonary arterial hypertension in Romanian children with congenital heart disease. Rev Romana Med Lab. 2013; 21(3):267-74. DOI: 10.2478/rrlm-2013-003110.2478/rrlm-2013-0031Open DOISearch in Google Scholar

15. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmöller J, Johne A et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A. 2000; 97(7):3473-8. DOI: 10.1073/pnas.97.7.347310.1073/pnas.97.7.34731626410716719Open DOISearch in Google Scholar

16. van der Deen M, de Vries EG, Timens W, Scheper RJ, Timmer-Bosscha H, Postma DS. ATP-binding cassette (ABC) transporters in normal and pathological lung. Respir Res. 2005; 6:59. DOI: 10.1186/1465-9921-6-5910.1186/1465-9921-6-59120043015967026Open DOISearch in Google Scholar

17. Manduz Ş, Katrancıoğlu N, Karahan O, Yılmaz MB, Özdemir Ö, Berkan Ö. Associations between common 3435 C>T variants of the multi-drug resistance [MDR-1 (ABCB1)] gene and abdominal aortic aneurysm: a pilot study. Turkish Journal of Thoracic and Cardiovascular Surgery. 2011; 19(2):177-81. DOI: 10.5606/tgkdc.dergisi.2011.00810.5606/tgkdc.dergisi.2011.008Open DOISearch in Google Scholar

18. Batetta B, Dessì S, Putzolu M, Sanna F, Spano O, Mulas MF et al. MDR1 gene expression in normal and atherosclerotic human arteries (1). J Vasc Res. 1999; 36:261-71. DOI: 10.1159/00002565410.1159/00002565410474039Open DOISearch in Google Scholar

19. Dombrowski SM, Desai SY, Marroni M, Cucullo L, Goodrich K, Bingaman W, et al. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia. 2001; 42:1501-6. DOI: 10.1046/j.1528-1157.2001.12301.x10.1046/j.1528-1157.2001.12301.x11879359Open DOISearch in Google Scholar

20. Bebek N, Çine N, Öner GÖ, Eşkazan E, Özbek U. Genotype and Allele frequencies of MDR-1 C3435T polymorphism in Turkish population. J Neurol Sci. 2005; 22(37):261-6.Search in Google Scholar

21. Ji-Ye Y, Qiong H, Youyun Y, Jian-Ting Z, Mei-Zuo Z, Hong-Hao Z, et al. Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population. Pharmacogenet Genomics. 2009; 19(3):206–16. DOI: 10.1097/FPC.0b013e328323f68010.1097/FPC.0b013e328323f680266720619214144Open DOISearch in Google Scholar

22. Tang K, Ngoi SM, Gwee PC, Chua JM, Lee EJ, Chong SS et al. Distinct haplotype profiles and strong linkage disequilibriumat the MDR1 multidrug transporter gene locus in three ethnic Asian populations. Pharmacogenetics. 2002; 12:437–50. DOI: 10.1097/00008571-200208000-0000410.1097/00008571-200208000-0000412172212Open DOISearch in Google Scholar

23. Wang LH, Song YB, Zheng WL, Jiang L, Wen-Li. The association between polymorphisms in the MDR1 gene and risk of cancer: a systematic review and pooled analysis of 52 case–control studies. Cancer Cell Int. 2013; 13:46. DOI: 10.1186/1475-2867-13-4610.1186/1475-2867-13-46366900123687985Open DOISearch in Google Scholar

24. Galie N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2016;37(1):67-119 DOI: 10.1093/eurheartj/ehv31710.1093/eurheartj/ehv31726320113Open DOISearch in Google Scholar

25. American Thoracic Society. American Thoracic Society statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002; 166:111-7. DOI: 10.1164/ajrccm.166.1.at110210.1164/ajrccm.166.1.at110212091180Open DOISearch in Google Scholar

26. Dong L, Luo R, Tong Y, Cai X, Mao M, Yu D. Lack of association between ABCB1 gene polymorphisms and pharmacoresistant epilepsy: an analysis in a western Chinese pediatric population. Brain Res. 2011; 1391:114-24. DOI: 10.1016/j.brainres.2011.03.02810.1016/j.brainres.2011.03.02821420937Open DOISearch in Google Scholar

27. Todoran Butila A, Sin A, Racoş Szabo E, Micheu C, Moldovan VG, Voidazan S et al. ABCB1 gene polymorphisms is not associated with drug-resistant epilepsy in Romanian children. Rev Romana Med Lab. 2015; 23(4):469-82. DOI: 10.1515/rrlm-2015-003710.1515/rrlm-2015-0037Open DOISearch in Google Scholar

28. Wolking S, Schaeffeler E, Lerche H, Schwab M, Nies AT. Impact of genetic polymorphisms of ABCB1 (MDR1, G-Glycoprotein) on drug disposition and potential clinical implications: update of the literature. Clin Pharmacokinet. 2015; 54(7):709-35. DOI: 10.1007/s40262-015-0267-110.1007/s40262-015-0267-125860377Open DOISearch in Google Scholar

29. Wartenberg M, Ling FC, Schallenberg M, Bäumer AT, Petrat K, Hescheler J et al. Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. J Biol Chem. 2001; 276(20):17420-8. DOI: 10.1074/jbc.M10014120010.1074/jbc.M10014120011279018Search in Google Scholar

30. Dorfmüller P, Perros F, Balabanian K, Hum-bert M. Inflammation in pulmonary arterial hypertension. Eur Respir J. 2003; 22:358–63. DOI: 10.1183/09031936.03.0003890310.1183/09031936.03.0003890312952274Open DOISearch in Google Scholar

31. Tuder RM, Groves B, Badesch DB, Voelkel NF. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol. 1994; 144:275–85.Search in Google Scholar

32. Sakamaki F, Kyotani S, Nagaya N, Nagato Sato N, Oya H, Satoh T, et al. Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hyper-tension were improved by continuous prostacyclin therapy. Circulation. 2000; 102:2720-5. DOI: 10.1161/01.CIR.102.22.272010.1161/01.CIR.102.22.2720Open DOISearch in Google Scholar

33. Sapmaz A, Ozen Karatayli SC, Dağli U, Kiliç ZM, Törüner M, Celik Y et al. Effects of polymorphism in G2677T/A triallelic region of MDR1 gene in Turkish patients with inflammatory bowel disease. Turk J Gastroenterol. 2008; 19:168-73.Search in Google Scholar

34. Kedmi M, Maayan S, Cohen SB, Hauzi M, Rund D. MDR1 and CYP3A4 polymorphisms are associated with HIV seropositivity in Israeli patients but do not influence the course of HIV disease. AIDS Patient Care STDS. 2007; 21:653-8. DOI: 10.1089/apc.2006.014810.1089/apc.2006.014817919092Search in Google Scholar

35. Elghannam DM, Ibrahim L, Ebrahim MA, Azmy E, Hakem H. Association of MDR1 gene polymorphism (G2677T) with imatinib response in Egyptian chronic myeloid leukemia patients. Hematology. 2014;19:123–8. DOI: 10.1179/1607845413Y.000000010210.1179/1607845413Y.000000010223683876Search in Google Scholar

36. Ma L, Liu H, Ruan L, Yang X, Yang H, Feng Y. Multi-drug resistance gene 1 C123T polymorphism and susceptibility to leukemia: a meta-analysis. Biomed Rep. 2015; 3(1):83-7. DOI: 10.3892/br.2014.38710.3892/br.2014.387425114925469253Open DOISearch in Google Scholar

37. Sabin O, Bocșan IC, Trifa A, Major ZZ, Heghes SC, Brusturean Bota E, et al. Correlation between ABCB1 gene polymorphisms, antiepileptic drug concentrations and treatment response. Rev Romana Med Lab. 2018 (ahead of print). DOI:10.2478/rrlm-2018-001210.2478/rrlm-2018-0012Open DOISearch in Google Scholar

38. Yamamoto-Furusho JK, Villeda-Ramirez MA, Fonseca-Camarillo G, Sanchez-Munoz F, Dominiquez-Lopez A, Barreto-Zuniga R, et al. High gene expression of MDR1 (ABCB1) is associated with medical treatment response and long-term remission in patients with ulcerative colitis. Inflam Bowel Dis. 2010; 16:541-2. DOI: 10.1002/ibd.2101610.1002/ibd.2101619714749Open DOISearch in Google Scholar

39. Milojkovic M, Milacic N, Radovic J, Ljubisavljevic S. MDR1 gene polymorphisms and p-glycoprotein expression in respiratory diseases. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015; 159(3):341-6. DOI: 10.5507/bp.2014.03210.5507/bp.2014.03224993742Open DOISearch in Google Scholar

40. Dogan OT, Katrancioglu N, Karahan O, Sanli GC, Zorlu A, Manduz S. Frequency of the MDR-1 C>T gene polymorphism in patients with COPD. Clinics (Sao Paulo). 2010; 65:1115-7.Search in Google Scholar

41. Martinelli M, Scapoli L, Pacilli AMG, Carbonara P, Girardi A, Mattei G, et al. Human Multidrug Resistance 1 gene polymorphisms and idiopathic pulmonary fibrosis. J Res Med Sci. 2015; 20(1):93-6.Search in Google Scholar

42. Takatsuki S, Ivy DD. Current Challenges in Pediatric Pulmonary Hypertension. Semin Respir Crit Care Med. 2013; 34(5):627-44. DOI: 10.1055/s-0033-135646110.1055/s-0033-1356461390967324037630Open DOISearch in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo