<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Vulvar cancer is a rare malignancy of the genital tract, the fourth most common type in this category. The most common form of the clinical appearance is long-lasting pruritus, a lump or mass on the vulva. Despite its histological type, in most cases, invasive vulvar cancer metastasizes primarily through the lymphatic system. Bone metastases related to gynecological cancers are rare, often underdiagnosed, and have a very poor prognosis. The most common site of metastasis in vulvar cancer is the lung, which is affected in about 45%, followed closely by the liver and brain. Bone metastases are present in about 10% to a quarter of cases. The most common places are the spine, pelvic bone, ribs, skull, limb bones and sternum. The only characteristic of the bone microenvironment is its high sensitivity to endocrine status, as vulvar cancer affects postmenopausal women. Thus, the theory of the protective role of estrogen on bone density and bone metastases remains an open door for future protection and treatment strategies.</p>
</abstract>

Vulvar cancer is a rare malignancy of the genital tract, the fourth most common type in this category. The most common form of the clinical appearance is long-lasting pruritus, a lump or mass on the vulva. Despite its histological type, in most cases, invasive vulvar cancer metastasizes primarily through the lymphatic system. Bone metastases related to gynecological cancers are rare, often underdiagnosed, and have a very poor prognosis. The most common site of metastasis in vulvar cancer is the lung, which is affected in about 45%, followed closely by the liver and brain. Bone metastases are present in about 10% to a quarter of cases. The most common places are the spine, pelvic bone, ribs, skull, limb bones and sternum. The only characteristic of the bone microenvironment is its high sensitivity to endocrine status, as vulvar cancer affects postmenopausal women. Thus, the theory of the protective role of estrogen on bone density and bone metastases remains an open door for future protection and treatment strategies.

Muscle-skeletal metastatic pattern in vulvar cancer

“Carol Davila” University of Medicine and Pharmacy; University Emergency Hospital Bucharest

“Carol Davila” University of Medicine and Pharmacy

Department of Orthopedics and Traumatology

Romanian Journal of Orthopaedic Surgery and Traumatology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Muscle-skeletal metastatic pattern in vulvar cancer"}

Vulvar cancer is a rare malignancy of the genital tract, the fourth most common type in this category. The most common form of the clinical appearance is...

Muscle-skeletal metastatic pattern in vulvar cancer

Published Online: May 14, 2022

Page range: 78 - 82

Accepted: Feb 21, 2022

DOI: https://doi.org/10.2478/rojost-2021-0014

Keywords
vulvar cancer, bone metastases, post-menopause, diagnosis

© 2021 Diana Secară et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Muscle-skeletal metastatic pattern in vulvar cancer

Published Online: May 14, 2022

Page range: 78 - 82

Accepted: Feb 21, 2022

DOI: https://doi.org/10.2478/rojost-2021-0014

Keywordsvulvar cancer, bone metastases, post-menopause, diagnosis

© 2021 Diana Secară et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
vulvar cancer, bone metastases, post-menopause, diagnosis