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Moroccan companies seek to be competitive worldwide by improving quality, productivity, and customer satisfaction. Lean Manufacturing and Six Sigma are the most popular methodologies for continuous improvement in companies. The objective of this article is to determine the impact of Six Sigma and Lean Manufacturing on the performance of different companies. The data was collected by a questionnaire sent to the various companies and industries in Morocco. 45 companies responded to this study, divided into several sectors. The criteria of this study are based on two levels: Financial and operational performance. A statistical study is carried out by SPSS software to analyze and interpret the collected results. The results of this study show that companies using Six Sigma and Lean Manufacturing methodologies have a positive financial and operational performance compared to companies that only use Lean Manufacturing or companies that do not use Six Sigma or Lean Manufacturing. Therefore, the combination of Six Sigma and Lean manufacturing is the ideal and perfect approach for the continuous improvement of different companies.