Short communication: Chlorpromazine causes a time-dependent decrease of lipids in Saccharomyces cerevisiae

Abernathy, CO, Lukacs, L, and Zimmerman, HJ. (1977). Adverse effects of chlorpromazine metabolites on isolated hepatocytes. Proc Soc Exp Biol Med155: 474–478.10.3181/00379727-155-39833Search in Google Scholar

Al-Attrache H, Chamieh H, Hamzé M, Morel I, Taha S, and Abdel-Razzak Z. (2018). N-acetylcysteine potentiates diclofenac toxicity in Saccharomyces cerevisiae: stronger potentiation in ABC transporter mutant strains. Drug Chem Toxicol41: 89–94.10.1080/01480545.2017.1320404Search in Google Scholar

Anderson GD, Chan L-N. (2016). Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products. Clin Pharmacokinet55: 1353–1368.10.1007/s40262-016-0400-9Search in Google Scholar

Antherieu S, Bachour-El Azzi P, Dumont J, Abdel-Razzak Z, Guguen-Guillouzo C, Fromenty B, Robin M-A, and Guillouzo A. (2013). Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells. Hepatol57: 1518–1529.10.1002/hep.26160Search in Google Scholar

Bachour-El Azzi P, Sharanek A, Abdel-Razzak Z, Antherieu S, Al-Attrache H, Savary CC, Lepage S, Morel I, Labbe G, Guguen-Guillouzo C, Guillouzo A. (2014). Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells. Drug Metab Dispos Biol Fate Chem42: 1556–1566.10.1124/dmd.114.058123Search in Google Scholar

Bowley M, Cooling J, Burditt SL, Brindley DN. (1977). The effects of amphiphilic cationic drugs and inorganic cations on the activity of phosphatidate phosphohydrolase. Biochem J165: 447–454.10.1042/bj1650447Search in Google Scholar

De Filippi L, Fournier M, Cameroni E, Linder P, De Virgilio C, Foti M, Deloche O. (2007). Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells. Curr Genet52: 171–185.10.1007/s00294-007-0151-0Search in Google Scholar

Dejanović B, Vuković-Dejanović V, Stevanović I, Stojanović I, Mandić Gajić G, Dilber S. (2017). Oxidative stress induced by chlorpromazine in patients treated and acutely poisoned with the drug. Vojnosanit Pregl73: 312–317.10.2298/VSP140423047DSearch in Google Scholar

Deloche O, de la Cruz J, Kressler D, Doère M, Linder P. (2004). A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae. Mol Cell13: 357–366.10.1016/S1097-2765(04)00008-5Search in Google Scholar

Dudley K, Liu X, De Haan S. (2017). Chlorpromazine dose for people with schizophrenia. Cochrane Database Syst Rev 4, CD007778.10.1002/14651858.CD007778.pub2647811628407198Search in Google Scholar

Hoshi K, Fujino S. (1992). Difference between effects of chlorpromazine and perphenazine on microsomal phospholipids and enzyme activities in rat liver. J Toxicol Sci17: 69–79.10.2131/jts.17.69Search in Google Scholar

Hu J, Kulkarni AP. (2000). Metabolic fate of chemical mixtures. I. “Shuttle Oxidant” effect of lipoxygenase-generated radical of chlorpromazine and related phenothiazines on the oxidation of benzidine and other xenobiotics. Teratog Carcinog Mutagen20: 195–208.10.1002/1520-6866(2000)20:4<195::AID-TCM2>3.0.CO;2-2Search in Google Scholar

Ide H, Nakazawa Y. (1980). Effect of chlorpromazine on the cytoplasmic phosphatidate phosphohydrolase in rat liver. Biochem Pharmacol29: 789–793.10.1016/0006-2952(80)90558-4Search in Google Scholar

Ide H, Nakazawa Y. (1981). Effect of chlorpromazine on intracellular transport of phospholipids. Chem Biol Interact34: 69–73.10.1016/0009-2797(81)90091-0Search in Google Scholar

Jassim G, Skrede S, Vázquez MJ, Wergedal H, Vik-Mo AO, Lunder N, Diéguez, C, Vidal-Puig A, Berge RK, López M, Steen VM, Fernø J. (2012). Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology (Berl.)219: 783–794.10.1007/s00213-011-2397-ySearch in Google Scholar

Kamada Y, Jung US, Piotrowski J, Levin DE. (1995). The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response. Genes Dev9: 1559–1571.10.1101/gad.9.13.1559Search in Google Scholar

Knittelfelder OL, Kohlwein SD. (2017). Lipid Extraction from Yeast Cells. Cold Spring Harb Protoc, 2017.10.1101/pdb.prot085449Search in Google Scholar

Martin A, Hopewell R, Martín-Sanz P, Morgan JE, Brindley DN. (1986). Relationship between the displacement of phosphatidate phosphohydrolase from the membrane-associated compartment by chlorpromazine and the inhibition of the synthesis of triacylglycerol and phosphatidylcholine in rat hepatocytes. Biochim Biophys Acta876: 581–591.10.1016/0005-2760(86)90047-0Search in Google Scholar

Morgan K, Martucci N, Kozlowska A, Gamal W, Brzeszczyński F, Treskes P, Samuel K, Hayes P, Nelson L, Bagnaninchi P, Brzeszczynska J, Plevris J. (2019). Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line. Biomed Pharmacother Biomedecine Pharmacother111: 1408–1416.10.1016/j.biopha.2019.01.020Search in Google Scholar

Parmentier C, Truisi GL, Moenks K, Stanzel S, Lukas A, Kopp-Schneider A, Alexandre E, Hewitt PG, Mueller SO, Richert L. (2013). Transcriptomic hepatotoxicity signature of chlorpromazine after short- and long-term exposure in primary human sandwich cultures. Drug Metab Dispos Biol Fate Chem41: 1835–1842.10.1124/dmd.113.052415Search in Google Scholar

Ros E, Small DM, and Carey MC. (1979). Effects of chlorpromazine hydrochlo-ride on bile salt synthesis, bile formation and biliary lipid secretion in the rhesus monkey: a model for chlorpromazine-induced cholestasis. Eur J Clin Invest9: 29–41.10.1111/j.1365-2362.1979.tb01664.xSearch in Google Scholar

Saari K, Koponen H, Laitinen J, Jokelainen J, Lauren L, Isohanni M, Lindeman S. (2004). Hyperlipidemia in persons using antipsychotic medication: a general population-based birth cohort study. J Clin Psychiatry65: 547–550.10.4088/JCP.v65n0415Search in Google Scholar

Sayyed K, Aljebeai A-K, Al-Nachar M, Chamieh H, Taha S, Abdel-Razzak Z. (2019). Interaction of cigarette smoke condensate and some of its components with chlorpromazine toxicity on Saccharomyces cerevisiae. Drug Chem Toxicol 1–11.10.1080/01480545.2019.165980931514548Search in Google Scholar

Simpson CE, Ashe MP. (2012). Adaptation to stress in yeast: to translate or not? Biochem Soc Trans40: 794–799.10.1042/BST2012007822817736Search in Google Scholar

Suzuki H, Gen K, Inoue Y. (2013). Comparison of the anti-dopamine D₂ and anti-serotonin 5-HT(2A) activities of chlorpromazine, bromperidol, haloperidol and second-generation antipsychotics parent compounds and metabolites thereof. J Psychopharmacol27: 396–400.10.1177/0269881113478281Search in Google Scholar

Tavoloni N, Boyer JL. (1980). Relationship between hepatic metabolism of chlorpromazine and cholestatic effects in the isolated perfused rat liver. J Pharmacol Exp Ther214: 269–274.Search in Google Scholar

Thakur MS, Prapulla SG, Karanth NG. (1989). Estimation of intracellular lipids by the measurement of absorbance of yeast cells stained with Sudan Black B. Enzyme Microb Technol11: 252–254.10.1016/0141-0229(89)90101-4Search in Google Scholar

Thyberg J, Axelsson JE, Hinek A. (1977). In vitro effects of chlorpromazine on microtubules and the Golgi complex in embryonic chick spinal ganglion cells: an electron microscopic study. Brain Res137: 323–332.10.1016/0006-8993(77)90342-0Search in Google Scholar

Wójcikowski J, Boksa J, Daniel WA. (2010). Main contribution of the cyto-chrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver--A comparison with other phenothiazines. Biochem Pharmacol80: 1252–1259.10.1016/j.bcp.2010.06.045Search in Google Scholar

Yeung PK, Hubbard JW, Korchinski ED, Midha KK. (1993). Pharmacokinetics of chlorpromazine and key metabolites. Eur J Clin Pharmacol45: 563–569.10.1007/BF00315316Search in Google Scholar