<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Probable changes were studied in rats’ immune status under experimental conditions with inhalation route of type I pyrethroid–imiprotrin administration, which is the main component of a number of household insecticidal agents. The drug at a concentration of 45.0 mg/m<sup>3</sup> interrupts immunological homeostasis in experimental animals. Nonspecific cellular component parameters of immune system have changed significantly. Imiprotrin is capable of inducing delayed hypersensitivity. Imiprotrin induces sensibilization under experimental conditions in more than half of the experimental animals, but the magnitude of the reactions to the intradermal administration of the drug has no probable differences, which allows imiprotin to be attributed to substances with moderate sensibilization potential</p></abstract>

Probable changes were studied in rats’ immune status under experimental conditions with inhalation route of type I pyrethroid–imiprotrin administration, which is the main component of a number of household insecticidal agents. The drug at a concentration of 45.0 mg/m3 interrupts immunological homeostasis in experimental animals. Nonspecific cellular component parameters of immune system have changed significantly. Imiprotrin is capable of inducing delayed hypersensitivity. Imiprotrin induces sensibilization under experimental conditions in more than half of the experimental animals, but the magnitude of the reactions to the intradermal administration of the drug has no probable differences, which allows imiprotin to be attributed to substances with moderate sensibilization potential

Experimental study of imiprotrin allergic potency in case of inhalation

Сentral research laboratory and laboratory of industrial toxicology

Danylo Halytsky Lviv National Medical University

Department of hygiene and prophylactic toxicology

Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Experimental study of imiprotrin allergic potency in case of inhalation"}

Probable changes were studied in rats’ immune status under experimental conditions with inhalation route of type I pyrethroid–imiprotrin administration, which...

Experimental study of imiprotrin allergic potency in case of inhalation

Published Online: Feb 20, 2020

Page range: 36 - 40

Received: Aug 10, 2018

Accepted: May 17, 2019

DOI: https://doi.org/10.2478/intox-2019-0005

Keywords
imiprotrin, immunological homeostasis, laboratory rats

© 2019 Oksana Hrushka et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Experimental study of imiprotrin allergic potency in case of inhalation

Published Online: Feb 20, 2020

Page range: 36 - 40

Received: Aug 10, 2018

Accepted: May 17, 2019

DOI: https://doi.org/10.2478/intox-2019-0005

Keywordsimiprotrin, immunological homeostasis, laboratory rats

© 2019 Oksana Hrushka et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
imiprotrin, immunological homeostasis, laboratory rats