<abstract xmlns="http://www.w3.org/1999/xhtml">

<italic>Biomphalaria alexandrina</italic> snails have received much attention due to their great medical importance as vectors for transmitting <italic>Schistosoma mansoni</italic> infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natural molluscicidal drug. The correlation between immunological and histological observations from light and electron microscopy of the hemocytes of <italic>B. alexandrina</italic> post treatment with both drugs was also evaluated. LC50 and LC90 values were represented by 13.80 ppm and 24.40 ppm for miltefosine and 16.88 ppm and 27.97 ppm for artemether, respectively. The results showed that the treatment of <italic>S. mansoni</italic>-infected snails and normal snails with sublethal dose of miltefosine (LC25=8.20 ppm) and artemether (LC25=11.04 ppm) induced morphological abnormalities and a significant reduction in hemocytes count.</abstract>

Biomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natural molluscicidal drug. The correlation between immunological and histological observations from light and electron microscopy of the hemocytes of B. alexandrina post treatment with both drugs was also evaluated. LC50 and LC90 values were represented by 13.80 ppm and 24.40 ppm for miltefosine and 16.88 ppm and 27.97 ppm for artemether, respectively. The results showed that the treatment of S. mansoni-infected snails and normal snails with sublethal dose of miltefosine (LC25=8.20 ppm) and artemether (LC25=11.04 ppm) induced morphological abnormalities and a significant reduction in hemocytes count.

Efficacy of Miltefosine and Artemether on infected <italic>Biomphalaria alexandrina</italic> snails with <italic>Schistosoma mansoni</italic>: immunological and histological studies

Helminthologia

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Efficacy of Miltefosine and Artemether on infected  snails with : immunological and histological studies

Biomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to...

Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies

Article Category: Research Article

Published Online: Nov 19, 2020

Page range: 335 - 343

Received: May 08, 2020

Accepted: Jul 08, 2020

DOI: https://doi.org/10.2478/helm-2020-0037

Keywords
miltefosine, artemether, hemocytes, immunological and histological studies, light and electron microscope

© 2020 H. H. Abdel-Azeem, G. Y. Osman, M. F. El Garhy, K. S. Al Benasy, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies

Article Category: Research Article

Published Online: Nov 19, 2020

Page range: 335 - 343

Received: May 08, 2020

Accepted: Jul 08, 2020

DOI: https://doi.org/10.2478/helm-2020-0037

Keywordsmiltefosine, artemether, hemocytes, immunological and histological studies, light and electron microscope

© 2020 H. H. Abdel-Azeem, G. Y. Osman, M. F. El Garhy, K. S. Al Benasy, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
miltefosine, artemether, hemocytes, immunological and histological studies, light and electron microscope