1. bookVolume 23 (2008): Issue 1 (April 2008)
Journal Details
License
Format
Journal
eISSN
2719-9509
First Published
01 Jan 1992
Publication timeframe
4 times per year
Languages
English
access type Open Access

A Modelling Approach to Develop Machine Smoking Protocols Reflecting Human Puffing Behaviour for Conventional Cigarettes

Published Online: 30 Dec 2014
Volume & Issue: Volume 23 (2008) - Issue 1 (April 2008)
Page range: 8 - 18
Received: 15 Jan 2007
Accepted: 15 Jun 2007
Journal Details
License
Format
Journal
eISSN
2719-9509
First Published
01 Jan 1992
Publication timeframe
4 times per year
Languages
English
Abstract

Our objective was to develop machine-smoking protocols (i.e. puff volume, puff duration and puff frequency) reflecting the distribution of human smoking behaviour as a complement to the International Standard (ISO) protocol. For this purpose, a modelling approach based on smoking topography and excretion data of urinary nicotine metabolites from clinical studies in the UK and Japan was used.

Three smoking protocols (LOW, MEDIUM and HIGH) were based on the 10th percentile, the mean and the 90th percentile of the puff volumes obtained from topography data. The corresponding puff durations were estimated by linear regression analysis of the puff duration/puff volume relationship. Finally, puff frequency was estimated using a predictive model assuming that the nicotine yield is a linear function (i.e. proportional) to the amount of air actually drawn through the burning part of the cigarette. This approach was termed ‘nicotine proportion method‘ where the puff frequency is changed iteratively until it equals the corresponding nicotine uptake measured in human smokers during a clinical study. The assumption was verified by measuring the nicotine yield in the laboratory on three modelled protocols for four conventional cigarettes. In 10 out of 12 cases, a very good agreement was observed between the estimated nicotine yields obtained with our modelling approach and the measured nicotine yields obtained from smoking machines in the laboratory.

Although smoking virtually identical cigarettes, smoking protocols based on topography and excretion data of urinary nicotine metabolites from the UK clinical study were different than those based on data from the study performed in Japan. This may be explained by different smoking behaviour between these two populations of smokers.

1. Ahijevych, K., H. Wee, and J. Clarke: Levels of cigarette availability and exposure in black and white women and efficient smokers; Pharmacol. Biochem. Behav. 77 (2004) 685–693.Search in Google Scholar

2. Ashton, H., R. Stepney, and J.W. Thompson: Self titration by cigarette smokers; Brit. Med. J. 2 (1997) 357–360.Search in Google Scholar

3. Baker, R.R.: The development and significance of standards for smoking-machine methodology; Beitr. Tabakforsch. Int. 20 (2002) 23–41.Search in Google Scholar

4. Benowitz, N.L. and P. Jacob: Daily intake of nicotine during cigarette smoking; Clin. Pharmacol. Ther. 35 (1984) 499-504.Search in Google Scholar

5. Benowitz, N.L. and P. Jacob: Nicotine and carbon monoxide intake from high- and low-yield cigarettes; Clin. Pharmacol. Ther. 36 (1984) 264-270.Search in Google Scholar

6. Bridges, R.B., J.G. Combs, J.W. Humble, J.A. Turbek, and NJ. Haley: Puffing topography as a determinant of smoke exposure; Pharmacol. Biochem. Behav. 37 (1990) 29-39.Search in Google Scholar

7. Bridges, R.B., J.W. Humble, J.A. Turbek, and S.R. Rehm: Smoking history, cigarette yield and smoking behavior as determinants of smoke exposure; Eur J Respir. Dis. 69 (1986) 129-137.Search in Google Scholar

8. Byrd, G.D., R.A. Davis, W.S. Caldwell, J.H. Robinson, and J.D. deBethizy: A further study of FTC yield and nicotine absorption in smokers; Psychopharma-cology 139 (1997) 291-299.Search in Google Scholar

9. Byrd, G.D., J.H. Robinson, W.S. Caldwell, and J.D. deBethizy: Comparison of measured and FTC-pre-dicted nicotine uptake in smokers; Psychopharmaco-logy 122 (1995) 95-103.Search in Google Scholar

10. Clark, P.I., S. Gautam, and L.W. Gerson: Effect of menthol cigarettes on biochemical markers of smoke exposure among black and white smokers; Chest 110 (1996) 1194-1198.Search in Google Scholar

11. Counts, M.E., M.J. Morton, S.W. Laffoon, R.H. Cox, and P.J. Lipowicz: Smoke composition and predicting relationships for international commercial cigarettes smoked with three machine-smoking conditions; Regul. Toxicol. Pharmacol. 41 (2005) 185-227.Search in Google Scholar

12. Dwyer, R.W., P. Chen, and R. Wasyk:. A mathema-tical scheme for calculating flows and pressure drops in lit and unlit cigarettes; Beitr. Tabakforsch. Int. 19 (2001) 189-203.Search in Google Scholar

13. Gori, G.B. and C.J. Lynch: Analytical cigarette yields as predictors of smoke bioavailability; Regul. Toxicol. Pharmacol. 5 (1985) 314-326.Search in Google Scholar

14. Hammond, D., G.T. Fong, K.M. Cummings, and A. Hyland: Smoking topography, brand switching, and nicotine delivery: results from an in vivo study; Cancer Epidemiol. Biomarkers Prev. 14 (2005) 1370-1375.Search in Google Scholar

15. Hammond, D., G.T. Fong, K.M. Cummings, R.J. O'Conner, G.A. Giovino, and A. McNeill: Cigarette yields and human exposure: A Comparison of alternative testing regimens; Cancer Epidemiol. Biomarkers Prev. 15 (2006) 1495-1501.Search in Google Scholar

16. Hearn, J. and F. Yang: Evaluation of CReSSMicroTM smoking measurements devices; Communication to S. Wrenn, R. Lee and S. Yang., personal communication, Philip Morris USA, 2004.Search in Google Scholar

17. International Organization for Standardization: Routine analytical cigarette-smoking machine - Defi-nitions and standard conditions; ISO 3308, 1991.Search in Google Scholar

18. Jarvis, M.J., R. Boreham, P. Primatesta, C. Feyer-abend, and A. Bryant: Nicotine yield from machine-smoked cigarettes and nicotine intakes in smokers: Evidence from a representative population survey; J. Natl. Cancer Inst. 93 (2001) 134-138.Search in Google Scholar

19. Kassel, J.D., J.E. Greenstein, D.P. Evatt, M.C. Wardle, M.C. Yates, J.C. Veilleux, and T. Eissenberg: Smoking topography in response to denicotinized and high-yield nicotine cigarettes in adolescent smokers; J. Adolesc. Health 40 (2007) 54–60.Search in Google Scholar

20. Kolonen, S., J. Tuomisto, P. Puustinen, and M.M. Airaksinen: Smoking behavior in low-yield cigarette smokers and switchers in the natural environment; Pharmacol. Biochem. Behav. 40 (1991) 177–180.Search in Google Scholar

21. Kozlowski, L.T., W.S. Rickert, M.A. Pope, J.C. Robinson, and R.C. Frecker: Estimating the yield to smokers of tar, nicotine and carbon monoxide from the lowest yield ventilated filter cigarettes; Brit. J. Addict. 77 (1982) 159–165.Search in Google Scholar

22. Moody, P.M.: The relationships of quantified human smoking behavior and demographic variables; Soc. Sci. Med. 14 A (1980) 49–54.Search in Google Scholar

23. Nil, R. and K. Bättig: Separate effects of cigarette smoke yield and smoke taste on smoking behavior; Psychopharmacology 99 (1989) 54–59.Search in Google Scholar

24. Pérez-Stable, E., B. Herrera, P.I. Jacob, and N.L. Benowitz: Nicotine metabolism and intake in black and white smokers; J. Am. Med. Assoc. 280 (1998) 152–156.Search in Google Scholar

25. Pillsbury, H.C.: Review of the Federal Trade Commission: Method for determining cigarette tar and nicotine yield; NCI Expert Committee, U.S. Department of Health and Human Services, National Institutes of Health, Monograph 7, Bethesda, MD, 1996.Search in Google Scholar

26. Pillsbury, H.C., C.C. Bright, R.J. O'Conner, and F.W. Irish: Tar and nicotine in cigarette smoke; J. Assoc. Off. Anal. Chem. 52 (1969) 458–462.Search in Google Scholar

27. Rickert, W.S. and J.C. Robinson: Estimating the hazards of less hazardous cigarettes, II: Study of cigarette yields of nicotine, carbon monoxide, and hydrogen cyanide in relation to levels of cotinine, carboxyhemoglobin and thiocynate in smokers; J Toxicol. Environ. Health 7 (1981) 391–403.Search in Google Scholar

28. Roethig, H.J., R.D. Kinser, R.W. Lau, R.A. Walk, and N. Wang: Short-term exposure evaluation of adult smokers switching from conventional to first-generation electrically heated cigarettes during controlled smoking; J. Clin. Pharmacol. 45 (2005) 133–145.Search in Google Scholar

29. Russell, M.A.H., M.J. Jarvis, R. Iyer, and C. Feyerabend: Relation of nicotine yield of cigarettes to blood concentrations in smokers; Brit. Med. J. 280 (1980) 972–976.Search in Google Scholar

30. Rustemeier, K. and J.J. Piadé: Determination of nicotine in mainstream and sidestream cigarette smoke; in; Analytical determination of nicotine and related compounds and their metabolites, edited by J. W. Gorrod and P.J.I. Peyton, Elsevier, Amsterdam, 1999, pp. 489–530.10.1016/B978-044450095-3/50013-9Search in Google Scholar

31. Strasser, A.A., R.L. Ashare, L.T. Kozlowski, and W.B. Pickworth: The effect of filter vent blocking and smoking topography on carbon monoxide levels in smokers; Pharmacol. Biochem. Behav. 82 (2005) 320–329.Search in Google Scholar

32. Watson, C., J. McCraw, G. Polzin, D. Ashley, and D. Barr: Development of a method to assess cigarette smoke intake; Environ. Sci. Technol 38 (2004) 248–253.Search in Google Scholar

33. Woodman, G., S.P. Newman, D. Pavia, and S.W. Clarke: Response and acclimatisation of symptomless smokers on changing to a low tar, low nicotine cigarette; Thorax 42 (1987) 336–341.Search in Google Scholar

34. Woodward, M. and H. Tunstall-Pedoe: Self-titration of nicotine: Evidence from the Scottish Heart Health Study; Addiction 88 (1993) 821–830.Search in Google Scholar

35. Zacny, J.P. and M.L. Stitzer: Cigarette brand-switching: Effects on smoke exposure and smoking behavior; J. Pharmacol. Exp. Ther. 246 (1988) 619–627.Search in Google Scholar

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