<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Insulin resistance is a heterogenous condition with high prevalence in medical practice. As diabesity reaches epidemic levels worldwide, the role of insulin resistance is getting great importance. Contribution of risk factors like sedentary lifestyle, diets high in saturated fats and refined carbohydrates leads to this state with significant consequences. Besides its role in diabetes, insulin resistance is also associated with other several endocrine diseases, having not only a role in their development, but also to their treatment approach, evolution and even prognosis. The present review summarizes the current literature on the clinical significance of insulin resistance, as well as the possible underlying mechanisms and treatment options in order to achieve a high quality of life of these categories of patients. Deepening the role of inflammatory cytokines involved in insulin resistance paves the way for future research findings in this continuously evolving field.</p>
</abstract>

Insulin resistance is a heterogenous condition with high prevalence in medical practice. As diabesity reaches epidemic levels worldwide, the role of insulin resistance is getting great importance. Contribution of risk factors like sedentary lifestyle, diets high in saturated fats and refined carbohydrates leads to this state with significant consequences. Besides its role in diabetes, insulin resistance is also associated with other several endocrine diseases, having not only a role in their development, but also to their treatment approach, evolution and even prognosis. The present review summarizes the current literature on the clinical significance of insulin resistance, as well as the possible underlying mechanisms and treatment options in order to achieve a high quality of life of these categories of patients. Deepening the role of inflammatory cytokines involved in insulin resistance paves the way for future research findings in this continuously evolving field.

Insulin resistance as risk factor for the development of type 2 diabetes mellitus: a systematic approach

Compartment of Diabetology, Emergency Clinical County Hospital of Targu Mures

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

Insulin resistance is a heterogenous condition with high prevalence in medical practice. As diabesity reaches epidemic levels worldwide, the role of insulin...

Insulin resistance as risk factor for the development of type 2 diabetes mellitus: a systematic approach

Article Category: REVIEW

Published Online: Dec 30, 2021

Page range: 187 - 192

Received: Oct 04, 2021

Accepted: Oct 21, 2021

DOI: https://doi.org/10.2478/amma-2021-0033

Keywords
insulin resistance, type 2 diabetes, obesity, cytokines, risk factor

© 2021 Reka Annamaria Schmiedt et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Insulin resistance as risk factor for the development of type 2 diabetes mellitus: a systematic approach

Article Category: REVIEW

Published Online: Dec 30, 2021

Page range: 187 - 192

Received: Oct 04, 2021

Accepted: Oct 21, 2021

DOI: https://doi.org/10.2478/amma-2021-0033

Keywordsinsulin resistance, type 2 diabetes, obesity, cytokines, risk factor

© 2021 Reka Annamaria Schmiedt et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
insulin resistance, type 2 diabetes, obesity, cytokines, risk factor