Metabolic and genetic derangement: a review of mechanisms involved in arsenic and lead toxicity and genotoxicity

1Vithanage M, Kumarathilaka P, Oze C, Karunatilake S, Seneviratne M, Hseu ZY, Gunarathne V, Dassanayake M, Ok YS, Rinklebe J. Occurrence and cycling of trace elements in ultramafic soils and their impacts on human health: A critical review. Environ Int 2019;131:104974. doi: 10.1016/j.envint.2019.104974 Vithanage M Kumarathilaka P Oze C Karunatilake S Seneviratne M Hseu ZY Gunarathne V Dassanayake M Ok YS Rinklebe J Occurrence and cycling of trace elements in ultramafic soils and their impacts on human health: A critical review Environ Int 2019131104974 10.1016/j.envint.2019.104974Open DOISearch in Google Scholar

2Wu W, Qu S, Nel W, Ji J. The impact of natural weathering and mining on heavy metal accumulation in the karst areas of the Pearl River Basin, China. Sci Total Environ 2020;734:139480. doi: 10.1016/j. scitotenv.2020.139480 Wu W Qu S Nel W Ji J The impact of natural weathering and mining on heavy metal accumulation in the karst areas of the Pearl River Basin, China Sci Total Environ 2020734139480 10.1016/j. scitotenv.2020.139480Open DOISearch in Google Scholar

3Hanfi MY, Mostafa MYA, Zhukovsky MV. Heavy metal contamination in urban surface sediments: sources, distribution, contamination control, and remediation. Environ Monit Assess 2019;192:32. doi: 10.1007/s10661-019-7947-5 Hanfi MY Mostafa MYA Zhukovsky MV Heavy metal contamination in urban surface sediments: sources, distribution, contamination control, and remediation Environ Monit Assess 201919232 10.1007/s10661-019-7947-5Open DOISearch in Google Scholar

4Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy metal toxicity and the environment. In: Luch A, editor. Molecular, clinical and environmental toxicology. Basel: Springer; 2012. p. 133–64. Tchounwou PB Yedjou CG Patlolla AK Sutton DJ Heavy metal toxicity and the environment In Luch A editor Molecular, clinical and environmental toxicology. Basel Springer 2012 p. 133 64Search in Google Scholar

5Singh A, Chauhan S, Varjani S, Pandey A, Bhargava PC. Integrated approaches to mitigate threats from emerging potentially toxic elements: A way forward for sustainable environmental management. Environ Res 2022;209:112844. doi: 10.1016/j.envres.2022.112844 Singh A Chauhan S Varjani S Pandey A Bhargava PC Integrated approaches to mitigate threats from emerging potentially toxic elements: A way forward for sustainable environmental management Environ Res 2022209112844 10.1016/j.envres.2022.112844Open DOISearch in Google Scholar

6Jeong H, Ryu JS, Ra K. Characteristics of potentially toxic elements and multi-isotope signatures (Cu, Zn, Pb) in non-exhaust traffic emission sources. Environ Pollut 2022;292:118339. doi: 10.1016/j. envpol.2021.118339 Jeong H Ryu JS Ra K Characteristics of potentially toxic elements and multi-isotope signatures (Cu, Zn, Pb) in non-exhaust traffic emission sources Environ Pollut 2022292118339 10.1016/j. envpol.2021.118339Open DOISearch in Google Scholar

7Mohiuddin AK. Heavy metals: the notorious daredevils of daily personal care products. Int J Pharm Pharm Res 2019;2:8–18. doi: 10.21694/2642-2980.19008 Mohiuddin AK Heavy metals: the notorious daredevils of daily personal care products Int J Pharm Pharm Res 201928 18 10.21694/2642-2980.19008Open DOISearch in Google Scholar

8WHO Regional Office for Europe & Joint WHO/Convention Task Force on the Health Aspects of Air Pollution. Health Risks of Heavy Metals from Long-Range Transboundary Air Pollution. Copenhagen: WHO Regional Office for Europe; 2007. WHO Regional Office for Europe & Joint WHO/Convention Task Force on the Health Aspects of Air Pollution. Health Risks of Heavy Metals from Long-Range Transboundary Air Pollution. Copenhagen WHO Regional Office for Europe; 2007Search in Google Scholar

9Fu X, Zhang H, Feng X, Tan Q, Ming L, Liu C, Zhang L. Domestic and transboundary sources of atmospheric particulate bound mercury in remote areas of China: evidence from mercury isotopes. Environ Sci Technol 2019;53:1947–57. doi: 10.1021/acs.est.8b06736 Fu X Zhang H Feng X Tan Q Ming L Liu C Zhang L Domestic and transboundary sources of atmospheric particulate bound mercury in remote areas of China: evidence from mercury isotopes Environ Sci Technol 2019531947 57 10.1021/acs.est.8b06736Open DOISearch in Google Scholar

10Natasha, Shahid M, Khalid S, Saleem M. Unrevealing arsenic and lead toxicity and antioxidant response in spinach: a human health perspective. Environ Geochem Health 2022;44:487–96. doi: 10.1007/ s10653-021-00818-0 Natasha Shahid M Khalid S Saleem M Unrevealing arsenic and lead toxicity and antioxidant response in spinach: a human health perspective Environ Geochem Health 202244487 96 10.1007/ s10653-021-00818-0Open DOISearch in Google Scholar

11Alina M, Azrina A, Mohd Yunus A, Mohd Zakiuddin S, Mohd Izuan Effendi H, Muhammad Rizal R. Heavy metals (mercury, arsenic, cadmium, plumbum) in selected marine fish and shellfish along the Straits of Malacca. Int Food Res J 2012;19:135–40 [displayed 25 October 2022]. Available at http://www.ifrj.upm.edu.my/19%20(01)%202011/(18)IFRJ-2010-235%20Alina.pdf Alina M Azrina A Mohd Yunus A Mohd Zakiuddin S Mohd Izuan Effendi H Muhammad Rizal R Heavy metals (mercury, arsenic, cadmium, plumbum) in selected marine fish and shellfish along the Straits of Malacca Int Food Res J 201219135 40 [displayed 25 October 2022]. Available at http://www.ifrj.upm.edu.my/19%20(01)%202011/(18)IFRJ-2010-235%20Alina.pdfSearch in Google Scholar

12Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN. Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 2014;7:60–72. doi: 10.2478/intox-2014-0009 Jaishankar M Tseten T Anbalagan N Mathew BB Beeregowda KN Toxicity, mechanism and health effects of some heavy metals Interdiscip Toxicol 2014760 72 10.2478/intox-2014-0009Open DOISearch in Google Scholar

13Engwa GA, Ferdinand PU, Nwalo FN, Unachukwu MN. Mechanism and health effects of heavy metal toxicity in humans. In: Karcioglu O, Arslan B, editors. Poisoning in the modern world - new tricks for an old dog? London: IntechOpen; 2019. doi: 10.5772/intechopen.82511 Engwa GA Ferdinand PU Nwalo FN Unachukwu MN Mechanism and health effects of heavy metal toxicity in humans In Karcioglu O Arslan B editors Poisoning in the modern world - new tricks for an old dog? London IntechOpen 2019 10.5772/intechopen.82511Open DOISearch in Google Scholar

14Anyanwu BO, Ezejiofor AN, Igweze ZN, Orisakwe OE. Heavy metal mixture exposure and effects in developing nations: an update. Toxics 2018;6(4):65. doi: 10.3390/toxics6040065 Anyanwu BO Ezejiofor AN Igweze ZN Orisakwe OE Heavy metal mixture exposure and effects in developing nations: an update Toxics 20186465 10.3390/toxics6040065Open DOISearch in Google Scholar

15Leonard SS, Bower JJ, Shi X. Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses. Mol Cell Biochem 2004;255:3–10. doi: 10.1023/b:mcbi.0000007255.72746.a6 Leonard SS Bower JJ Shi X Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses Mol Cell Biochem 20042553 10 10.1023/b:mcbi.0000007255.72746.a6Open DOISearch in Google Scholar

16Zhu Y, Costa M. Metals and molecular carcinogenesis. Carcinogenesis 2020;41:1161–72. doi: 10.1093/carcin/bgaa076 Zhu Y Costa M Metals and molecular carcinogenesis Carcinogenesis 2020411161 72 10.1093/carcin/bgaa076Open DOISearch in Google Scholar

17Fu Z, Xi S. The effects of heavy metals on human metabolism. Toxicol Mech Methods 2020;30:167–76. doi: 10.1080/15376516.2019.1701594 Fu Z Xi S The effects of heavy metals on human metabolism Toxicol Mech Methods 202030167 76 10.1080/15376516.2019.1701594Open DOISearch in Google Scholar

18ARSDR Agency for Toxic Substances and Disease Registry. ATSDR’s Substance Priority List, 2019 [displayed 08 September 2022]. Available at https://www.atsdr.cdc.gov/spl/index.html ARSDR Agency for Toxic Substances and Disease Registry. ATSDR’s Substance Priority List, 2019 [displayed 08 September 2022]. Available at https://www.atsdr.cdc.gov/spl/index.htmlSearch in Google Scholar

19Briffa J. Heavy Metals in Maltese Agricultural Soil. [Master thesis]. Malta: University of Malta; 2020. Briffa J Heavy Metals in Maltese Agricultural Soil. [Master thesis] Malta University of Malta 2020Search in Google Scholar

20Chung JY, Yu SD, Hong YS. Environmental source of arsenic exposure. J Prev Med Public Health 2014;47:253–7. doi: 10.3961/jpmph.14.036 Chung JY Yu SD Hong YS Environmental source of arsenic exposure J Prev Med Public Health 201447253 7 10.3961/jpmph.14.036Open DOISearch in Google Scholar

21Matta G, Gjyli L. Mercury, lead and arsenic: impact on environment and human health. J Chem Pharm Sci 2016;9:718–25 [displayed 25 October 2022]. Available at https://jchps.com/issues/Volume%209_Issue%202/jchps%209(2)%2010%20Gagan%20Matta.pdf Matta G Gjyli L Mercury, lead and arsenic: impact on environment and human health J Chem Pharm Sci 20169718 25 [displayed 25 October 2022]. Available at https://jchps.com/issues/Volume%209_Issue%202/jchps%209(2)%2010%20Gagan%20Matta.pdfSearch in Google Scholar

22Kuivenhoven M, Mason K. Arsenic Toxicity. [Updated 2022 Jun 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan [displayed 27 October 2022]. Available at https://www.ncbi.nlm.nih.gov/books/NBK541125/ Kuivenhoven M Mason K Arsenic Toxicity. [Updated 2022 Jun 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan [displayed 27 October 2022]. Available at https://www.ncbi.nlm.nih.gov/books/NBK541125/Search in Google Scholar

23Chávez-Capilla T. The need to unravel arsenolipid transformations in humans. DNA Cell Biol 2022;41:64–70. doi: 10.1089/dna.2021.0476 Chávez-Capilla T. The need to unravel arsenolipid transformations in humans DNA Cell Biol 20224164 70 10.1089/dna.2021.0476Open DOISearch in Google Scholar

24Sanyal T, Bhattacharjee P, Paul S, Bhattacharjee P. Recent advances in arsenic research: significance of differential susceptibility and sustainable strategies for mitigation. Front Public Health 2020;8:464. doi: 10.3389/fpubh.2020.00464 Sanyal T Bhattacharjee P Paul S Bhattacharjee P Recent advances in arsenic research: significance of differential susceptibility and sustainable strategies for mitigation Front Public Health 20208464 10.3389/fpubh.2020.00464Open DOISearch in Google Scholar

25Pakulska D, Czerczak S. Hazardous effects of arsine: a short review. Int J Occup Med Environ Health 2006;19:36–44. doi: 10.2478/v10001-006-0003-z Pakulska D Czerczak S Hazardous effects of arsine: a short review Int J Occup Med Environ Health 20061936 44 10.2478/v10001-006-0003-zOpen DOISearch in Google Scholar

26Nieuwenhuijsen MJ, Toledano MB, Eaton NE, Fawell J, Elliott P. Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review. Occup Environ Med 2000;57:73–85. doi: 10.1136/oem.57.2.73 Nieuwenhuijsen MJ Toledano MB Eaton NE Fawell J Elliott P Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review Occup Environ Med 20005773 85 10.1136/oem.57.2.73Open DOISearch in Google Scholar

27Zuzolo D, Cicchella D, Demetriades A, Birke M, Albanese S, Dinelli E, Lima A, Valera P, De Vivo B. Arsenic: Geochemical distribution and age-related health risk in Italy. Environ Res 2020;182:109076. doi: 10.1016/j.envres.2019.109076 Zuzolo D Cicchella D Demetriades A Birke M Albanese S Dinelli E Lima A Valera P De Vivo B Arsenic: Geochemical distribution and age-related health risk in Italy Environ Res 2020182109076 10.1016/j.envres.2019.109076Open DOISearch in Google Scholar

28Briffa J, Sinagra E, Blundell R. Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon 2020;6(9):e04691. doi: 10.1016/j.heliyon.2020.e04691 Briffa J Sinagra E Blundell R Heavy metal pollution in the environment and their toxicological effects on humans Heliyon 202069e04691 10.1016/j.heliyon.2020.e04691Open DOISearch in Google Scholar

29Blessing Ebele O. Mechanisms of arsenic toxicity and carcinogenesis. Afr J Biochem Res 2009;3(5):232–7. Blessing Ebele O Mechanisms of arsenic toxicity and carcinogenesis Afr J Biochem Res 200935232 7Search in Google Scholar

30Twaddle NC, Vanlandingham M, Beland FA, Doerge DR. Metabolism and disposition of arsenic species from controlled dosing with dimethylarsinic acid (DMA^V) in adult female CD-1 mice. V. Toxicokinetic studies following oral and intravenous administration. Food Chem Toxicol 2019;130:22–31. doi: 10.1016/j.fct.2019.04.045 Twaddle NC Vanlandingham M Beland FA Doerge DR Metabolism and disposition of arsenic species from controlled dosing with dimethylarsinic acid (DMA^V) in adult female CD-1 mice V. Toxicokinetic studies following oral and intravenous administration. Food Chem Toxicol 201913022 31 10.1016/j.fct.2019.04.045Open DOISearch in Google Scholar

31Yu H, Liu S, Li M, Wu B. Influence of diet, vitamin, tea, trace elements and exogenous antioxidants on arsenic metabolism and toxicity. Environ Geochem Health 2016;38:339–51. doi: 10.1007/s10653-015-9742-8 Yu H Liu S Li M Wu B Influence of diet, vitamin, tea, trace elements and exogenous antioxidants on arsenic metabolism and toxicity Environ Geochem Health 201638339 51 10.1007/s10653-015-9742-8Open DOISearch in Google Scholar

32Hu Y, Li J, Lou B, Wu R, Wang G, Lu C, Wang H, Pi J, Xu Y. The role of reactive oxygen species in arsenic toxicity. Biomolecules 2020;10(2):240. doi: 10.3390/biom10020240 Hu Y Li J Lou B Wu R Wang G Lu C Wang H Pi J Xu Y The role of reactive oxygen species in arsenic toxicity Biomolecules 2020102240 10.3390/biom10020240Open DOISearch in Google Scholar

33Kligerman A, Tennant A. Insights into the carcinogenic mode of action of arsenic. Toxicol Appl Pharmacol 2007;222:281–8. doi: 10.1016/j.taap.2006.10.006 Kligerman A Tennant A Insights into the carcinogenic mode of action of arsenic Toxicol Appl Pharmacol 2007222281 8 10.1016/j.taap.2006.10.006Open DOISearch in Google Scholar

34Ng JC. Environmental contamination of arsenic and its toxicological impact on humans. Environ Chem 2005;2:146–60. doi: 10.1071/EN05062 Ng JC Environmental contamination of arsenic and its toxicological impact on humans Environ Chem 20052146 60 10.1071/EN05062Open DOISearch in Google Scholar

35Kitchin KT, Conolly R. Arsenic-induced carcinogenesis - oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment. Chem Res Toxicol 2010;23:327–35. doi: 10.1021/tx900343d Kitchin KT Conolly R Arsenic-induced carcinogenesis - oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment Chem Res Toxicol 201023327 35 10.1021/tx900343dOpen DOISearch in Google Scholar

36Palma-Lara I, Martínez-Castillo M, Quintana-Pérez JC, Arellano-Mendoza MG, Tamay-Cach F, Valenzuela-Limón OL, García-Montalvo EA, Hernández-Zavala A. Arsenic exposure: a public health problem leading to several cancers. Regul Toxicol Pharmacol 2020;110:104539. doi: 10.1016/j.yrtph.2019.104539 Palma-Lara I Martínez-Castillo M Quintana-Pérez JC Arellano-Mendoza MG Tamay-Cach F Valenzuela-Limón OL García-Montalvo EA Hernández-Zavala A Arsenic exposure: a public health problem leading to several cancers Regul Toxicol Pharmacol 2020110104539 10.1016/j.yrtph.2019.104539Open DOISearch in Google Scholar

37Zhou Q, Xi S. A review on arsenic carcinogenesis: epidemiology, metabolism, genotoxicity and epigenetic changes. Regul Toxicol Pharmacol 2018;99:78–88. doi: 10.1016/j.yrtph.2018.09.010 Zhou Q Xi S A review on arsenic carcinogenesis: epidemiology, metabolism, genotoxicity and epigenetic changes Regul Toxicol Pharmacol 20189978 88 10.1016/j.yrtph.2018.09.010Open DOISearch in Google Scholar

38Rhodes CE, Denault D, Varacallo M. Physiology, Oxygen Transport. [Updated 2021 Nov 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan [displayed 27 October 2022]. Available at https://www.ncbi.nlm.nih.gov/books/NBK538336/ Rhodes CE Denault D Varacallo M Physiology, Oxygen Transport. [Updated 2021 Nov 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan [displayed 27 October 2022]. Available at https://www.ncbi.nlm.nih.gov/books/NBK538336/Search in Google Scholar

39Hughes MF. Arsenic toxicity and potential mechanisms of action. Toxicol Lett 2002;133:1–16. doi: 10.1016/s0378-4274(02)00084-x Hughes MF Arsenic toxicity and potential mechanisms of action Toxicol Lett 20021331 16 10.1016/s0378-4274(02)00084-xOpen DOISearch in Google Scholar

40Kulshrestha A, Jarouliya U, Prasad G, Flora S, Bisen PS. Arsenic-induced abnormalities in glucose metabolism: biochemical basis and potential therapeutic and nutritional interventions. World J Transl Med 2014;3:96–111. doi: 10.5528/wjtm.v3.i2.96 Kulshrestha A Jarouliya U Prasad G Flora S Bisen PS Arsenic-induced abnormalities in glucose metabolism: biochemical basis and potential therapeutic and nutritional interventions World J Transl Med 2014396 111 10.5528/wjtm.v3.i2.96Open DOISearch in Google Scholar

41Fan C, Liu G, Long Y, Rosen B, Cai Y. Thiolation in arsenic metabolism: a chemical perspective. Metallomics 2018;10:1368–82. doi: 10.1039/c8mt00231b Fan C Liu G Long Y Rosen B Cai Y Thiolation in arsenic metabolism: a chemical perspective Metallomics 2018101368 82 10.1039/c8mt00231bOpen DOISearch in Google Scholar

42Walton FS, Harmon AW, Paul DS, Drobná Z, Patel YM, Styblo M. Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes. Toxicol Appl Pharmacol 2004;198:424–33. doi: 10.1016/j.taap.2003.10.026 Walton FS Harmon AW Paul DS Drobná Z Patel YM Styblo M Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes Toxicol Appl Pharmacol 2004198424 33 10.1016/j.taap.2003.10.026Open DOISearch in Google Scholar

43Stýblo M, Venkatratnam A, Fry RC, Thomas DJ. Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects. Arch Toxicol 2021;95:1547–72. doi: 10.1007/s00204-021-03028-w Stýblo M Venkatratnam A Fry RC Thomas DJ Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects Arch Toxicol 2021951547 72 10.1007/s00204-021-03028-wOpen DOISearch in Google Scholar

44Srivastava S, Flora SJ. Arsenicals: toxicity, their use as chemical warfare agents, and possible remedial measures. In: Gupta RC, editor. Handbook of toxicology of chemical warfare agents. Cambridge: Academic Press; 2020. p. 303–19. Srivastava S Flora SJ Arsenicals: toxicity, their use as chemical warfare agents, and possible remedial measures In Gupta RC editor Handbook of toxicology of chemical warfare agents Cambridge Academic Press 2020 p. 303 19Search in Google Scholar

45Liu Y, Zhao H, Wang Y, Guo M, Mu M, Xing M. Arsenic (III) and/ or copper (II) induces oxidative stress in chicken brain and subsequent effects on mitochondrial homeostasis and autophagy. J Inorg Biochem 2020;211:111201. doi: 10.1016/j.jinorgbio.2020.111201 Liu Y Zhao H Wang Y Guo M Mu M Xing M Arsenic (III) and/ or copper (II) induces oxidative stress in chicken brain and subsequent effects on mitochondrial homeostasis and autophagy J Inorg Biochem 2020211111201 10.1016/j.jinorgbio.2020.111201Open DOISearch in Google Scholar

46Li JX, Shen YQ, Cai BZ, Zhao J, Bai X, Lu YJ, Li XQ. Arsenic trioxide induces the apoptosis in vascular smooth muscle cells via increasing intracellular calcium and ROS formation. Mol Biol Rep 2010;37:1569–76. doi: 10.1007/s11033-009-9561-z Li JX Shen YQ Cai BZ Zhao J Bai X Lu YJ Li XQ Arsenic trioxide induces the apoptosis in vascular smooth muscle cells via increasing intracellular calcium and ROS formation Mol Biol Rep 2010371569 76 10.1007/s11033-009-9561-zOpen DOISearch in Google Scholar

47Lynn S, Gurr JR, Lai HT, Jan KY. NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells. Circ Res 2000;86:514–9. doi: 10.1161/01.res.86.5.514 Lynn S Gurr JR Lai HT Jan KY NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells Circ Res 200086514 9 10.1161/01.res.86.5.514Open DOISearch in Google Scholar

48Liu SX, Athar M, Lippai I, Waldren C, Hei TK. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc Natl Acad Sci USA 2001;98:1643–8. doi: 10.1073/pnas.98.4.1643 Liu SX Athar M Lippai I Waldren C Hei TK Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity Proc Natl Acad Sci USA 2001981643 8 10.1073/pnas.98.4.1643Open DOISearch in Google Scholar

49Tam LM, Wang Y. Arsenic exposure and compromised protein quality control. Chem Res Toxicol 2020;33:1594–604. doi: 10.1021/acs. chemrestox.0c00107 Tam LM Wang Y Arsenic exposure and compromised protein quality control Chem Res Toxicol 2020331594 604 10.1021/acs. chemrestox.0c00107Open DOISearch in Google Scholar

50Valko M, Jomova K, Rhodes CJ, Kuča K, Musílek K. Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol 2016;90:1–37. doi: 10.1007/s00204-015-1579-5 Valko M Jomova K Rhodes CJ Kuča K Musílek K Redox- and non-redox-metal-induced formation of free radicals and their role in human disease Arch Toxicol 2016901 37 10.1007/s00204-015-1579-5Open DOISearch in Google Scholar

51Ran S, Liu J, Li S. A Systematic review of the various effect of arsenic on glutathione synthesis in vitro and in vivo. Biomed Res Int 2020;2020:9414196. doi: 10.1155/2020/9414196 Ran S Liu J Li S A Systematic review of the various effect of arsenic on glutathione synthesis in vitro and in vivo Biomed Res Int 202020209414196 10.1155/2020/9414196Open DOISearch in Google Scholar

52Singh R, Misra AN, Sharma P. Effect of arsenate toxicity on antioxidant enzymes and expression of nicotianamine synthase in contrasting genotypes of bioenergy crop Ricinus communis. Environ Sci Pollut Res Int 2021;28:31421–30. doi: 10.1007/s11356-021-12701-7 Singh R Misra AN Sharma P Effect of arsenate toxicity on antioxidant enzymes and expression of nicotianamine synthase in contrasting genotypes of bioenergy crop Ricinus communis Environ Sci Pollut Res Int 20212831421 30 10.1007/s11356-021-12701-7Open DOISearch in Google Scholar

53Askevold JE. Arsenic and ADHD-Perinatal exposure to Arsenic species in breastmilk and ADHD in adolescents [Project thesis]. Oslo: Faculty of Medicine, University of Oslo; 2022 [displayed 27 October 2022]. Available at https://www.duo.uio.no/bitstream/handle/10852/94054/1/Kappe-Arsenic-og-ADHD.pdf Askevold JE Arsenic and ADHD-Perinatal exposure to Arsenic species in breastmilk and ADHD in adolescents [Project thesis]. Oslo: Faculty of Medicine, University of Oslo; 2022 [displayed 27 October 2022]. Available at https://www.duo.uio.no/bitstream/handle/10852/94054/1/Kappe-Arsenic-og-ADHD.pdfSearch in Google Scholar

54Meyer S, Schulz J, Jeibmann A, Taleshi MS, Ebert F, Francesconi KA, Schwerdtle T. Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster. Metallomics 2014;6:2010–4. doi: 10.1039/c4mt00249k Meyer S Schulz J Jeibmann A Taleshi MS Ebert F Francesconi KA Schwerdtle T Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster Metallomics 201462010 4 10.1039/c4mt00249kOpen DOISearch in Google Scholar

55Niehoff AC, Schulz J, Soltwisch J, Meyer S, Kettling H, Sperling M, Jeibmann A, Dreisewerd K, Francesconi KA, Schwerdtle T, Karst U. Imaging by elemental and molecular mass spectrometry reveals the uptake of an arsenolipid in the brain of Drosophila melanogaster. Anal Chem 2016;88:5258–63. doi: 10.1021/acs.analchem.6b00333 Niehoff AC Schulz J Soltwisch J Meyer S Kettling H Sperling M Jeibmann A Dreisewerd K Francesconi KA Schwerdtle T Karst U Imaging by elemental and molecular mass spectrometry reveals the uptake of an arsenolipid in the brain of Drosophila melanogaster Anal Chem 2016885258 63 10.1021/acs.analchem.6b00333Open DOISearch in Google Scholar

56Xue XM, Xiong C, Yoshinaga M, Rosen B, Zhu YG. The enigma of environmental organoarsenicals: insights and implications. Crit Rev E nv iron Sc i Te c h no l 2 0 2 2 ; 5 2 : 3 8 3 5 – 6 2 . do i : 10.1080/10643389.2021.1947678 Xue XM Xiong C Yoshinaga M Rosen B Zhu YG The enigma of environmental organoarsenicals: insights and implications. Crit Rev E nv iron Sc i Te c h no l 2 0 2 2 ; 5 2 : 3 8 3 5 – 6 2 . do i : 10.1080/10643389.2021.1947678Search in Google Scholar

57Mac Monagail M, Morrison L. Arsenic speciation in a variety of seaweeds and associated food products. Compr Anal Chem 2019;85:267–310. 10.1016/bs.coac.2019.03.005 Mac Monagail M Morrison L Arsenic speciation in a variety of seaweeds and associated food products Compr Anal Chem 201985267 310 10.1016/bs.coac.2019.03.005Open DOISearch in Google Scholar

58Flora SJ. Arsenic-induced oxidative stress and its reversibility. Free Radic Biol Med 2011;51:257–81. doi : 10.1016/j.freeradbiomed.2011.04.008 Flora SJ Arsenic-induced oxidative stress and its reversibility Free Radic Biol Med 201151257 81 doi: 10.1016/j.freeradbiomed.2011.04.008Search in Google Scholar

59Liu G, Song Y, Li C, Liu R, Chen Y, Yu L, Huang Q, Zhu D, Lu C, Yu X, Xiao C, Liu Y. Arsenic compounds: the wide application and mechanisms applied in acute promyelocytic leukemia and carcinogenic toxicology. Eur J Med Chem 2021;221:113519. doi: 10.1016/j. ejmech.2021.113519 Liu G Song Y Li C Liu R Chen Y Yu L Huang Q Zhu D Lu C Yu X Xiao C Liu Y Arsenic compounds: the wide application and mechanisms applied in acute promyelocytic leukemia and carcinogenic toxicology Eur J Med Chem 2021221113519 10.1016/j. ejmech.2021.113519Open DOISearch in Google Scholar

60Martin EM, Fry RC. Environmental influences on the epigenome: exposure- associated DNA methylation in human populations. Annu Rev Public Health 2018;39:309–33. doi: 10.1146/annurev-publhealth-040617-014629 Martin EM Fry RC Environmental influences on the epigenome: exposure- associated DNA methylation in human populations Annu Rev Public Health 201839309 33 10.1146/annurev-publhealth-040617-014629Open DOISearch in Google Scholar

61Nuta O, Bouffler S, Lloyd D, Ainsbury E, Sepai O, Rothkamm K. Investigating the impact of long term exposure to chemical agents on the chromosomal radiosensitivity using human lymphoblastoid GM1899A cells. Sci Rep 2021;11:12616. doi: 10.1038/s41598-021-91957-y Nuta O Bouffler S Lloyd D Ainsbury E Sepai O Rothkamm K Investigating the impact of long term exposure to chemical agents on the chromosomal radiosensitivity using human lymphoblastoid GM1899A cells Sci Rep 20211112616 10.1038/s41598-021-91957-yOpen DOISearch in Google Scholar

62Patlolla AK, Todorov TI, Tchounwou PB, van der Voet G, Centeno JA. Arsenic-induced biochemical and genotoxic effects and distribution in tissues of Sprague-Dawley rats. Microchem J 2012;105:101–7. doi: 10.1016/j.microc.2012.08.013 Patlolla AK Todorov TI Tchounwou PB van der Voet G Centeno JA Arsenic-induced biochemical and genotoxic effects and distribution in tissues of Sprague-Dawley rats Microchem J 2012105101 7 10.1016/j.microc.2012.08.013Open DOISearch in Google Scholar

63Demanelis K, Argos M, Tong L, Shinkle J, Sabarinathan M, Rakibuz-Zaman M, Sarwar G, Shahriar H, Islam T, Rahman M, Yunus M, Graziano JH, Broberg K, Engström K, Jasmine F, Ahsan H, Pierce BL. Association of arsenic exposure with whole blood DNA methylation: an epigenome-wide study of Bangladeshi adults. Environ Health Perspect 2019;127(5):057011. doi: 10.1289/EHP3849 Demanelis K Argos M Tong L Shinkle J Sabarinathan M Rakibuz-Zaman M Sarwar G Shahriar H Islam T Rahman M Yunus M Graziano JH Broberg K Engström K Jasmine F Ahsan H Pierce BL Association of arsenic exposure with whole blood DNA methylation: an epigenome-wide study of Bangladeshi adults Environ Health Perspect 20191275057011 10.1289/EHP3849Open DOISearch in Google Scholar

64Tam LM, Price NE, Wang Y. Molecular mechanisms of arsenic-induced disruption of DNA repair. Chem Res Toxicol 2020;33:709–26. doi: 10.1021/acs.chemrestox.9b00464 Tam LM Price NE Wang Y Molecular mechanisms of arsenic-induced disruption of DNA repair Chem Res Toxicol 202033709 26 10.1021/acs.chemrestox.9b00464Open DOISearch in Google Scholar

65Moura DJ, Péres VF, Jacques RA, Saffi J. Heavy metal toxicity: oxidative stress parameters and DNA repair. In: Gupta D, Sandalio L, editors. Metal toxicity in plants: perception, signaling and remediation. Berlin, Heidelberg: Springer; 2012. p. 187–205 doi: 10.1007/978-3-642-220814_9 Moura DJ Péres VF Jacques RA Saffi J Heavy metal toxicity: oxidative stress parameters and DNA repair In Gupta D Sandalio L editors Metal toxicity in plants: perception, signaling and remediation. Berlin, Heidelberg Springer 2012 p. 187 205 10.1007/978-3-642-220814_9Open DOISearch in Google Scholar

66Kligerman AD, Doerr CL, Tennant AH, Harrington-Brock K, Allen JW, Winkfield E, Poorman-Allen P, Kundu B, Funasaka K, Roop BC, Mass MJ, DeMarini DM. Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations. Environ Mol Mutagen 2003;42:192–205. doi: 10.1002/em.10192 Kligerman AD Doerr CL Tennant AH Harrington-Brock K Allen JW Winkfield E Poorman-Allen P Kundu B Funasaka K Roop BC Mass MJ DeMarini DM Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations Environ Mol Mutagen 200342192 205 10.1002/em.10192Open DOISearch in Google Scholar

67Renu K, Saravanan A, Elangovan A, Ramesh S, Annamalai S, Namachivayam A, Abel P, Madhyastha H, Madhyastha R, Maruyama M, Balachandar V, Valsala Gopalakrishnan A. An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity. Life Sci 2020;260:118438. doi: 10.1016/j.lfs.2020.118438 Renu K Saravanan A Elangovan A Ramesh S Annamalai S Namachivayam A Abel P Madhyastha H Madhyastha R Maruyama M Balachandar V Valsala Gopalakrishnan A An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity Life Sci 2020260118438 10.1016/j.lfs.2020.118438Open DOISearch in Google Scholar

68Tchounwou PB, Centeno JA, Patlolla AK. Arsenic toxicity, mutagenesis, and carcinogenesis - a health risk assessment and management approach. Mol Cell Biochem 2004;255:47–55. doi: 10.1023/b:mcbi.0000007260.32981.b9 Tchounwou PB Centeno JA Patlolla AK Arsenic toxicity, mutagenesis, and carcinogenesis - a health risk assessment and management approach Mol Cell Biochem 200425547 55 10.1023/b:mcbi.0000007260.32981.b9Open DOISearch in Google Scholar

69Nasrollahzadeh A, Bashash D, Kabuli M, Zandi Z, Kashani B, Zaghal A, Mousavi SA, Ghaffari SH. Arsenic trioxide and BIBR1532 synergistically inhibit breast cancer cell proliferation through attenuation of NF-κB signaling pathway. Life Sci 2020;257:118060. doi: 10.1016/j.lfs.2020.118060 Nasrollahzadeh A Bashash D Kabuli M Zandi Z Kashani B Zaghal A Mousavi SA Ghaffari SH Arsenic trioxide and BIBR1532 synergistically inhibit breast cancer cell proliferation through attenuation of NF-κB signaling pathway Life Sci 2020257118060 10.1016/j.lfs.2020.118060Open DOISearch in Google Scholar

70Wei M, Liu J, Xu M, Rui D, Xu S, Feng G, Ding Y, Li S, Guo S. Divergent effects of arsenic on NF-κB signaling in different cells or tissues: a systematic review and meta-analysis. Int J Environ Res Public Health 2016;13(2):163. doi: 10.3390/ijerph13020163 Wei M Liu J Xu M Rui D Xu S Feng G Ding Y Li S Guo S Divergent effects of arsenic on NF-κB signaling in different cells or tissues: a systematic review and meta-analysis Int J Environ Res Public Health 2016132163 10.3390/ijerph13020163Open DOISearch in Google Scholar

71Oeckinghaus A, Ghosh S. The NF-κB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 2009;1(4):a000034. doi: 10.1101/cshperspect.a000034 Oeckinghaus A Ghosh S The NF-κB family of transcription factors and its regulation Cold Spring Harb Perspect Biol 200914a000034 10.1101/cshperspect.a000034Open DOISearch in Google Scholar

72Jin W, Xue Y, Xue Y, Han X, Song Q, Zhang J, Li Z, Cheng J, Guan S, Sun S, Chu L. Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways. Biomed Pharmacother 2020;126:110047. doi: 10.1016/j.biopha.2020.110047 Jin W Xue Y Xue Y Han X Song Q Zhang J Li Z Cheng J Guan S Sun S Chu L Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways Biomed Pharmacother 2020126110047 10.1016/j.biopha.2020.110047Open DOISearch in Google Scholar

73Karin M, Delhase M. The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling. Semin Immunol 2000;12:85–98. doi: 10.1006/smim.2000.0210 Karin M Delhase M The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling Semin Immunol 20001285 98 10.1006/smim.2000.0210Open DOISearch in Google Scholar

74Chen F, Shi X. Signaling from toxic metals to NF-κB and beyond: not just a matter of reactive oxygen species. Environ Health Perspect 2002;110(Suppl 5):807–11. doi: 10.1289/ehp.02110s5807 Chen F Shi X Signaling from toxic metals to NF-κB and beyond: not just a matter of reactive oxygen species Environ Health Perspect 2002110Suppl 5807 11 10.1289/ehp.02110s5807Open DOISearch in Google Scholar

75Medda N, De SK, Maiti S. Different mechanisms of arsenic related signaling in cellular proliferation, apoptosis and neo-plastic transformation. Ecotoxicol Environ Saf 2021;208:111752. doi: 10.1016/j.ecoenv.2020.111752 Medda N De SK Maiti S Different mechanisms of arsenic related signaling in cellular proliferation, apoptosis and neo-plastic transformation Ecotoxicol Environ Saf 2021208111752 10.1016/j.ecoenv.2020.111752Open DOISearch in Google Scholar

76He X, Ma Q. NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation. Mol Pharmacol 2009;76:1265–78. doi: 10.1124/mol.109.058453 He X Ma Q NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation Mol Pharmacol 2009761265 78 10.1124/mol.109.058453Open DOISearch in Google Scholar

77He X, Wang L, Szklarz G, Bi Y, Ma Q. Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathway. J Pharmacol Exp Ther 2012;342:81–90. doi: 10.1124/jpet.112.194142 He X Wang L Szklarz G Bi Y Ma Q Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathway J Pharmacol Exp Ther 201234281 90 10.1124/jpet.112.194142Open DOISearch in Google Scholar

78Zhong L, Hao H, Chen D, Hou Q, Zhu Z, He W, Sun S, Sun M, Li M, Fu X. Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway. J Cell Physiol 2019;234:2606–17. doi: 10.1002/jcp.27073 Zhong L Hao H Chen D Hou Q Zhu Z He W Sun S Sun M Li M Fu X Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway J Cell Physiol 20192342606 17 10.1002/jcp.27073Open DOISearch in Google Scholar

79Massrieh W, Derjuga A, Blank V. Induction of endogenous Nrf2/small maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells. Antioxid Redox Signal 2006;8:53–9. doi: 10.1089/ars.2006.8.53 Massrieh W Derjuga A Blank V Induction of endogenous Nrf2/small maf heterodimers by arsenic-mediated stress in placental choriocarcinoma cells Antioxid Redox Signal 2006853 9 10.1089/ars.2006.8.53Open DOISearch in Google Scholar

80Wang L, Kou MC, Weng CY, Hu LW, Wang YJ, Wu MJ. Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways. Arch Toxicol 2012;86:879–96. doi: 10.1007/s00204-012-0845-z Wang L Kou MC Weng CY Hu LW Wang YJ Wu MJ Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways Arch Toxicol 201286879 96 10.1007/s00204-012-0845-zOpen DOISearch in Google Scholar

81Eckstein M, Eleazer R, Rea M, Fondufe-Mittendorf Y. Epigenomic reprogramming in inorganic arsenic-mediated gene expression patterns during carcinogenesis. Rev Environ Health 2017;32:93–103. doi: 10.1515/reveh-2016-0025 Eckstein M Eleazer R Rea M Fondufe-Mittendorf Y Epigenomic reprogramming in inorganic arsenic-mediated gene expression patterns during carcinogenesis Rev Environ Health 20173293 103 10.1515/reveh-2016-0025Open DOISearch in Google Scholar

82Thomas DJ. Arsenic methylation - Lessons from three decades of research. Toxicology 2021;457:152800. doi: 10.1016/j.tox.2021.152800 Thomas DJ Arsenic methylation - Lessons from three decades of research Toxicology 2021457152800 10.1016/j.tox.2021.152800Open DOISearch in Google Scholar

83Cheng TF, Choudhuri S, Muldoon-Jacobs K. Epigenetic targets of some toxicologically relevant metals: a review of the literature. J Appl Toxicol 2012;32:643–53. doi: 10.1002/jat.2717 Cheng TF Choudhuri S Muldoon-Jacobs K Epigenetic targets of some toxicologically relevant metals: a review of the literature J Appl Toxicol 201232643 53 10.1002/jat.2717Open DOISearch in Google Scholar

84Mukhopadhyay P, Greene RM, Pisano MM. Cigarette smoke induces proteasomal-mediated degradation of DNA methyltransferases and methyl CpG-/CpG domain-binding proteins in embryonic orofacial cells. Reprod Toxicol 2015;58:140–8. doi: 10.1016/j. reprotox.2015.10.009 Mukhopadhyay P Greene RM Pisano MM Cigarette smoke induces proteasomal-mediated degradation of DNA methyltransferases and methyl CpG-/CpG domain-binding proteins in embryonic orofacial cells Reprod Toxicol 201558140 8 10.1016/j. reprotox.2015.10.009Open DOISearch in Google Scholar

85Pogribna M, Hammons G. Epigenetic effects of nanomaterials and nanoparticles. J Nanobiotechnology 2021;19:2. doi: 10.1186/s12951-020-00740-0 Pogribna M Hammons G Epigenetic effects of nanomaterials and nanoparticles J Nanobiotechnology 2021192 10.1186/s12951-020-00740-0Open DOISearch in Google Scholar

86Li H, He J, Ju P, Zhong X, Liu J. Studies on the mechanism of arsenic trioxide-induced apoptosis in HepG₂ human hepatocellular carcinoma cells. Chin J Clin Oncol 2008;5:22–5. doi: 10.1007/s11805-008-0022-6 Li H He J Ju P Zhong X Liu J Studies on the mechanism of arsenic trioxide-induced apoptosis in HepG₂ human hepatocellular carcinoma cells Chin J Clin Oncol 2008522 5 10.1007/s11805-008-0022-6Open DOISearch in Google Scholar

87Cai X, Yu L, Chen Z, Ye F, Ren Z, Jin P. Arsenic trioxide-induced upregulation of miR-1294 suppresses tumor growth in hepatocellular carcinoma by targeting TEAD1 and PIM1. Cancer Biomark 2020;28:221–30. doi: 10.3233/cbm-190490 Cai X Yu L Chen Z Ye F Ren Z Jin P Arsenic trioxide-induced upregulation of miR-1294 suppresses tumor growth in hepatocellular carcinoma by targeting TEAD1 and PIM1 Cancer Biomark 202028221 30 10.3233/cbm-190490Open DOISearch in Google Scholar

88Jing-Jing Z, Xiao-Jie C, Wen-Dong Y, Ying-Hui W, Hang-Sheng Z, Hong-Yue Z, Zhi-Hong Z, Bin-Hui W, Fan-Zhu. Fabrication of a folic acid-modified arsenic trioxide prodrug liposome and assessment of its anti-hepatocellular carcinoma activity. Dig Chin Med 2020;3:260–74. doi: 10.1016/j.dcmed.2020.12.005 Jing-Jing Z Xiao-Jie C Wen-Dong Y Ying-Hui W Hang-Sheng Z Hong-Yue Z Zhi-Hong Z Bin-Hui W Fan-Zhu Fabrication of a folic acid-modified arsenic trioxide prodrug liposome and assessment of its anti-hepatocellular carcinoma activity Dig Chin Med 20203260 74 10.1016/j.dcmed.2020.12.005Open DOISearch in Google Scholar

89Zhang F, Duan J, Song H, Yang L, Zhou M, Wang X. Combination of canstatin and arsenic trioxide suppresses the development of hepatocellular carcinoma. Drug Dev Res 2021;82:430–9. doi: 10.1002/ ddr.21766 Zhang F Duan J Song H Yang L Zhou M Wang X Combination of canstatin and arsenic trioxide suppresses the development of hepatocellular carcinoma Drug Dev Res 202182430 9 10.1002/ ddr.21766Open DOISearch in Google Scholar

90Chen Y, Li H, Chen D, Jiang X, Wang W, Li D, Shan H. Hypoxic hepatocellular carcinoma cells acquire arsenic trioxide resistance by upregulating HIF-1α expression. Dig Dis Sci 2022;67:3806–16. doi: 10.1007/s10620-021-07202-z Chen Y Li H Chen D Jiang X Wang W Li D Shan H Hypoxic hepatocellular carcinoma cells acquire arsenic trioxide resistance by upregulating HIF-1α expression Dig Dis Sci 2022673806 16 10.1007/s10620-021-07202-zOpen DOISearch in Google Scholar

91Fang Y, Zhang Z. Arsenic trioxide as a novel anti-glioma drug: a review. Cell Mol Biol Lett 2020;25:44. doi: 10.1186/s11658-020-00236-7 Fang Y Zhang Z Arsenic trioxide as a novel anti-glioma drug: a review Cell Mol Biol Lett 20202544 10.1186/s11658-020-00236-7Open DOISearch in Google Scholar

92Siddique R, Khan S, Bai Q, Li H, Ullah MW, Xue M. Arsenic Trioxide-based nanomedicines as a therapeutic combination approach for treating gliomas: a review. Curr Nanosci 2021;17:406–17. doi: 10.217 4/1573413716999201207142810 Siddique R Khan S Bai Q Li H Ullah MW Xue M Arsenic Trioxide-based nanomedicines as a therapeutic combination approach for treating gliomas: a review Curr Nanosci 202117406 17 10.217 4/1573413716999201207142810Open DOISearch in Google Scholar

93Sönksen M, Kerl K, Bunzen H. Current status and future prospects of nanomedicine for arsenic trioxide delivery to solid tumors. Med Res Rev 2021;42:374–98. doi: 10.1002/med.21844 Sönksen M Kerl K Bunzen H Current status and future prospects of nanomedicine for arsenic trioxide delivery to solid tumors Med Res Rev 202142374 98 10.1002/med.21844Open DOISearch in Google Scholar

94Genchi G, Lauria G, Catalano A, Carocci A, Sinicropi MS. Arsenic: a review on a great health issue worldwide. Appl Sci 2022;12(12):6184. doi: 10.3390/app12126184 Genchi G Lauria G Catalano A Carocci A Sinicropi MS Arsenic: a review on a great health issue worldwide Appl Sci 202212126184 10.3390/app12126184Open DOISearch in Google Scholar

95Gamboa-Loira B, Cebrián ME, Franco-Marina F, López-Carrillo L. Arsenic metabolism and cancer risk: a meta-analysis. Environ Res 2017;156:551–8. doi: 10.1016/j.envres.2017.04.016 Gamboa-Loira B Cebrián ME Franco-Marina F López-Carrillo L Arsenic metabolism and cancer risk: a meta-analysis Environ Res 2017156551 8 10.1016/j.envres.2017.04.016Open DOISearch in Google Scholar

96Nurchi VM, Djordjevic AB, Crisponi G, Alexander J, Bjørklund G, Aaseth J. Arsenic toxicity: molecular targets and therapeutic agents. Biomolecules 2020;10(2):235. doi: 10.3390/biom10020235 Nurchi VM Djordjevic AB Crisponi G Alexander J Bjørklund G Aaseth J Arsenic toxicity: molecular targets and therapeutic agents Biomolecules 2020102235 10.3390/biom10020235Open DOISearch in Google Scholar

97Wani A, Ara A, Usmani JA. Lead toxicity: a review. Interdiscip Toxicol 2015;8:55–64. doi: 10.1515/intox-2015-0009 Wani A Ara A Usmani JA Lead toxicity: a review Interdiscip Toxicol 2015855 64 10.1515/intox-2015-0009Open DOISearch in Google Scholar

98Çelebi H, Gök G, Gök O. Adsorption capability of brewed tea waste in waters containing toxic lead(II), cadmium(II), nickel(II), and zinc(II) heavy metal ions. Sci Rep 2020;10(1):17570. doi: 10.1038/s41598-020-74553-4 Çelebi H Gök G Gök O Adsorption capability of brewed tea waste in waters containing toxic lead(II), cadmium(II), nickel(II), and zinc(II) heavy metal ions Sci Rep 202010117570 10.1038/s41598-020-74553-4Open DOISearch in Google Scholar

99World Health Organization. Lead poisoning [displayed 5 September 2022]. Available at https://www.who.int/news-room/fact-sheets/detail/lead-poisoning-and-health World Health Organization Lead poisoning [displayed 5 September 2022]. Available at https://www.who.int/news-room/fact-sheets/detail/lead-poisoning-and-healthSearch in Google Scholar

100Charkiewicz AE, Backstrand JR. Lead toxicity and pollution in Poland. Int J Environ Res Public Health 2020;17(12):4385. doi: 10.3390/ijerph17124385 Charkiewicz AE Backstrand JR Lead toxicity and pollution in Poland Int J Environ Res Public Health 202017124385 10.3390/ijerph17124385Open DOISearch in Google Scholar

101Rehman K, Fatima F, Waheed I, Akash MSH. Prevalence of exposure of heavy metals and their impact on health consequences. J Cell Biochem 2018;119:157–84. doi: 10.1002/jcb.26234 Rehman K Fatima F Waheed I Akash MSH Prevalence of exposure of heavy metals and their impact on health consequences J Cell Biochem 2018119157 84 10.1002/jcb.26234Open DOISearch in Google Scholar

102Samarghandian S, Shirazi FM, Saeedi F, Roshanravan B, Pourbagher-Shahri AM, Khorasani EY, Farkhondeh T, Aaseth JO, Abdollahi M, Mehrpour O. A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports. Toxicol Appl Pharmacol 2021;429:115681. doi: 10.1016/j.taap.2021.115681 Samarghandian S Shirazi FM Saeedi F Roshanravan B Pourbagher-Shahri AM Khorasani EY Farkhondeh T Aaseth JO Abdollahi M Mehrpour O A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports Toxicol Appl Pharmacol 2021429115681 10.1016/j.taap.2021.115681Open DOISearch in Google Scholar

103Papanikolaou NC, Hatzidaki EG, Belivanis S, Tzanakakis GN, Tsatsakis AM. Lead toxicity update. A brief review. Med Sci Monit 2005;11(10):RA329–36. PMID: 16192916 Papanikolaou NC Hatzidaki EG Belivanis S Tzanakakis GN Tsatsakis AM Lead toxicity update. A brief review. Med Sci Monit 20051110RA329 36 PMID: 16192916Search in Google Scholar

104Centers for Disease Control and Prevention. Low Level Lead Exposure Harms Children: A Renewed Call for Primary Prevention - Report of the Advisory Committee on Childhood Lead Poisoning Prevention of the Centers for Disease Control and Prevention, 2012 [displayed 28 October 2022]. Available at http://www.cdc.gov/nceh/lead/acclpp/final_document_030712.pdf Centers for Disease Control and Prevention Low Level Lead Exposure Harms Children: A Renewed Call for Primary Prevention - Report of the Advisory Committee on Childhood Lead Poisoning Prevention of the Centers for Disease Control and Prevention, 2012 [displayed 28 October 2022]. Available at http://www.cdc.gov/nceh/lead/acclpp/final_document_030712.pdfSearch in Google Scholar

105Raymond J, Brown MJ. Childhood blood lead levels in children aged <5 years - United States, 2009–2014. MMWR Surveill Summ 2017;66:1–10. doi: 10.15585/mmwr.ss6603a1 Raymond J Brown MJ Childhood blood lead levels in children aged <5 years - United States, 2009–2014 MMWR Surveill Summ 2017661 10 10.15585/mmwr.ss6603a1Open DOISearch in Google Scholar

106Dignam T, Kaufmann RB, LeStourgeon L, Brown MJ. Control of lead sources in the United States, 1970–2017: Public health progress and current challenges to eliminating lead exposure. J Public Health Manag Pract 2019;25(Suppl 1):S13–22. doi: 10.1097/phh.0000000000000889 Dignam T Kaufmann RB LeStourgeon L Brown MJ Control of lead sources in the United States, 1970–2017: Public health progress and current challenges to eliminating lead exposure J Public Health Manag Pract 201925Suppl 1S13 22 10.1097/phh.0000000000000889Open DOISearch in Google Scholar

107Flannery BM, Middleton KB. Updated interim reference levels for dietary lead to support FDA’s Closer to Zero action plan. Regul Toxicol Pharmacol 2022;133:105202. doi: 10.1016/j.yrtph.2022.105202 Flannery BM Middleton KB Updated interim reference levels for dietary lead to support FDA’s Closer to Zero action plan Regul Toxicol Pharmacol 2022133105202 10.1016/j.yrtph.2022.105202Open DOISearch in Google Scholar

108Lubos E, Loscalzo J, Handy DE. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2011;15(7):1957–97. doi: 10.1089/ars.2010.3586 Lubos E Loscalzo J Handy DE Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities Antioxid Redox Signal 20111571957 97 10.1089/ars.2010.3586Open DOISearch in Google Scholar

109Mitra P, Sharma S, Purohit P, Sharma P. Clinical and molecular aspects of lead toxicity: An update. Crit Rev Clin Lab Sci 2017;54:506–28. doi: 10.1080/10408363.2017.1408562 Mitra P Sharma S Purohit P Sharma P Clinical and molecular aspects of lead toxicity: An update Crit Rev Clin Lab Sci 201754506 28 10.1080/10408363.2017.1408562Open DOISearch in Google Scholar

110Flora G, Gupta D, Tiwari A. Toxicity of lead: A review with recent updates. Interdiscip Toxicol 2012;5(2):47–58. doi: 10.2478/v10102-012-0009-2 Flora G Gupta D Tiwari A Toxicity of lead: A review with recent updates Interdiscip Toxicol 20125247 58 10.2478/v10102-012-0009-2Open DOISearch in Google Scholar

111Obeng-Gyasi E. Lead exposure and oxidative stress - A life course approach in US adults. Toxics 2018;6(3):42. doi: 10.3390/toxics6030042 Obeng-Gyasi E. Lead exposure and oxidative stress - A life course approach in US adults Toxics 20186442 10.3390/toxics6030042Open DOISearch in Google Scholar

112Jiang X, Xing X, Zhang Y, Zhang C, Wu Y, Chen Y, Meng R, Jia H, Cheng Y, Zhang Y, Su J. Lead exposure activates the Nrf2/Keap1 pathway, aggravates oxidative stress, and induces reproductive damage in female mice. Ecotoxicol Environ Saf 2021;207:111231. doi: 10.1016/j.ecoenv.2020.111231 Jiang X Xing X Zhang Y Zhang C Wu Y Chen Y Meng R Jia H Cheng Y Zhang Y Su J Lead exposure activates the Nrf2/Keap1 pathway, aggravates oxidative stress, and induces reproductive damage in female mice Ecotoxicol Environ Saf 2021207111231 10.1016/j.ecoenv.2020.111231Open DOISearch in Google Scholar

113Gurer-Orhan H, Sabır HU, Özgüneş H. Correlation between clinical indicators of lead poisoning and oxidative stress parameters in controls and lead-exposed workers. Toxicology 2004;195:147–54. doi: 10.1016/j.tox.2003.09.009 Gurer-Orhan H Sabır HU Özgüneş H Correlation between clinical indicators of lead poisoning and oxidative stress parameters in controls and lead-exposed workers Toxicology 2004195147 54 10.1016/j.tox.2003.09.009Open DOISearch in Google Scholar

114La-Llave-León O, Méndez-Hernández EM, Castellanos-Juárez FX, Esquivel-Rodríguez E, Vázquez-Alaniz F, Sandoval-Carrillo A, García-Vargas G, Duarte-Sustaita J, Candelas-Rangel JL, Salas-Pacheco JM. Association between blood lead levels and delta-aminolevulinic acid dehydratase in pregnant women. Int J Environ Res Public Health 2017;14(4):432. doi: 10.3390/ijerph14040432 La-Llave-León O Méndez-Hernández EM Castellanos-Juárez FX Esquivel-Rodríguez E Vázquez-Alaniz F Sandoval-Carrillo A García-Vargas G Duarte-Sustaita J Candelas-Rangel JL Salas-Pacheco JM Association between blood lead levels and delta-aminolevulinic acid dehydratase in pregnant women Int J Environ Res Public Health 2017144432 10.3390/ijerph14040432Open DOISearch in Google Scholar

115Andrade V, Mateus ML, Batoréu, MC, Aschner M, Dos Santos AM. Urinary delta-ALA: a potential biomarker of exposure and neurotoxic effect in rats co-treated with a mixture of lead, arsenic and manganese. Neurotoxicology 2013;38:33–41. doi: 10.1016/j.neuro.2013.06.003 Andrade V Mateus ML Batoréu MC Aschner M Dos Santos AM Urinary delta-ALA: a potential biomarker of exposure and neurotoxic effect in rats co-treated with a mixture of lead, arsenic and manganese Neurotoxicology 20133833 41 10.1016/j.neuro.2013.06.003Open DOISearch in Google Scholar

116Ibrahem S, Hassan M, Ibraheem Q, Arif K. Genotoxic effect of lead and cadmium on workers at wastewater plant in Iraq. J Environ Public Health 2020;2020:9171027. doi: 10.1155/2020/9171027 Ibrahem S Hassan M Ibraheem Q Arif K Genotoxic effect of lead and cadmium on workers at wastewater plant in Iraq J Environ Public Health 202020209171027 10.1155/2020/9171027Open DOISearch in Google Scholar

117Sridevi SK, Umamaheswari S. Human exposure to lead, mechanism of toxicity and treatment strategy - a review. J Clin Diagnostic Res 2020;14(12):LE01–5. doi: 10.7860/JCDR/2020/45615.14345 Sridevi SK Umamaheswari S Human exposure to lead, mechanism of toxicity and treatment strategy - a review J Clin Diagnostic Res 20201412LE01–5 10.7860/JCDR/2020/45615.14345Open DOISearch in Google Scholar

118Patra R, Rautray AK, Swarup D. Oxidative stress in lead and cadmium toxicity and its amelioration. Vet Med Int 2011;2011:457327. doi: 10.4061/2011/457327 Patra R Rautray AK Swarup D Oxidative stress in lead and cadmium toxicity and its amelioration Vet Med Int 20112011457327 10.4061/2011/457327Open DOISearch in Google Scholar

119Wyparło-Wszelaki M, Wąsik M, Machoń-Grecka A, Kasperczyk A, Bellanti F, Kasperczyk S, Dobrakowski M. Blood magnesium level and selected oxidative stress indices in lead-exposed workers. Biol Trace Elem Res 2021;199:465–72. doi: 10.1007/s12011-020-02168-x Wyparło-Wszelaki M Wąsik M Machoń-Grecka A Kasperczyk A Bellanti F Kasperczyk S Dobrakowski M Blood magnesium level and selected oxidative stress indices in lead-exposed workers Biol Trace Elem Res 2021199465 72 10.1007/s12011-020-02168-xOpen DOISearch in Google Scholar

120Adeyemi WJ, Abdussalam TA, Abdulrahim A, Olayaki LA. Elevated, sustained, and yet reversible biotoxicity effects of lead on cessation of exposure: Melatonin is a potent therapeutic option. Toxicol Ind Health 2020;36:477–86. doi: 10.1177/0748233720937199 Adeyemi WJ Abdussalam TA Abdulrahim A Olayaki LA Elevated, sustained, and yet reversible biotoxicity effects of lead on cessation of exposure: Melatonin is a potent therapeutic option Toxicol Ind Health 202036477 86 10.1177/0748233720937199Open DOISearch in Google Scholar

121Virgolini MB, Aschner M. Molecular mechanisms of lead neurotoxicity. Adv Neurotoxicol 2021;5:159–213. doi: 10.1016/bs.ant.2020.11.002 Virgolini MB Aschner M Molecular mechanisms of lead neurotoxicity Adv Neurotoxicol 20215159 213 10.1016/bs.ant.2020.11.002Open DOISearch in Google Scholar

122Jangid AP, Shekhawat V, Pareek H, Yadav D, Sharma P, John P. Effect of lead on human blood antioxidant enzymes and glutathione. Int J Biochem Res Rev 2016;13(1):1–9. Jangid AP Shekhawat V Pareek H Yadav D Sharma P John P Effect of lead on human blood antioxidant enzymes and glutathione Int J Biochem Res Rev 20161311 9Search in Google Scholar

123Kshirsagar MS, Patil JA, Patil A. Increased blood lead level induces oxidative stress and alters the antioxidant status of spray painters. J Basic Clin Physiol Pharmacol 2020;31(2):20180229. doi: 10.1515/jbcpp-2018-0229 Kshirsagar MS Patil JA Patil A Increased blood lead level induces oxidative stress and alters the antioxidant status of spray painters J Basic Clin Physiol Pharmacol 202031220180229 10.1515/jbcpp-2018-0229Open DOISearch in Google Scholar

124Sadhu HG, Amin BK, Parikh DJ, Sathawara NG, Mishra U, Virani BK, Lakkad BC, Shivgotra VK, Patel S. Poisoning of workers working in small lead-based units. Indian J Occup Environ Med 2008;12:139–41. doi: 10.4103/0019-5278.44697 Sadhu HG Amin BK Parikh DJ Sathawara NG Mishra U Virani BK Lakkad BC Shivgotra VK Patel S Poisoning of workers working in small lead-based units Indian J Occup Environ Med 200812139 41 10.4103/0019-5278.44697Open DOISearch in Google Scholar

125Sirati-Sabet M, Asadikaram G, Ilghari D, Gheibi N, Torkman F, Abdolvahabi Z, Khabbaz F. The effect of lead on erythrocyte glucose-6-phosphate dehydrogenase activity in rats. Biotech Health Sci 2014;1(1):e19192. doi: 10.17795/bhs-19192 Sirati-Sabet M Asadikaram G Ilghari D Gheibi N Torkman F Abdolvahabi Z Khabbaz F The effect of lead on erythrocyte glucose-6-phosphate dehydrogenase activity in rats Biotech Health Sci 201411e19192 10.17795/bhs-19192Open DOISearch in Google Scholar

126Flora S, Mittal M, Mehta A. Heavy metal induced oxidative stress and its possible reversal by chelation therapy. Indian J Med Res 2008;128:501–23. PMID: 19106443 Flora S Mittal M Mehta A Heavy metal induced oxidative stress and its possible reversal by chelation therapy Indian J Med Res 2008128501 23 PMID: 19106443Search in Google Scholar

127Lachant NA, Tomoda A, Tanaka KR. Inhibition of the pentose phosphate shunt by lead: a potential mechanism for hemolysis in lead poisoning. Blood 1984;63:518–24. doi: 10.1182/blood.V63.3.518.518 Lachant NA Tomoda A Tanaka KR Inhibition of the pentose phosphate shunt by lead: a potential mechanism for hemolysis in lead poisoning Blood 198463518 24 10.1182/blood.V63.3.518.518Open DOISearch in Google Scholar

128Moniuszko-Jakoniuk J, Jurczuk M, Brzóska MM. Evaluation of glutathione-related enzyme activities in the liver and kidney of rats exposed to lead and ethanol. Pharmacol Rep 2007;59(Suppl 1):217–25. Moniuszko-Jakoniuk J Jurczuk M Brzóska MM Evaluation of glutathione-related enzyme activities in the liver and kidney of rats exposed to lead and ethanol Pharmacol Rep 200759Suppl 1217 25Search in Google Scholar

129Dobrakowski M, Pawlas N, Kasperczyk A, Kozłowska A, Olewińska E, Machoń-Grecka A, Kasperczyk S. Oxidative DNA damage and oxidative stress in lead-exposed workers. Hum Exp Toxicol 2017;36:744–54. doi: 10.1177/0960327116665674 Dobrakowski M Pawlas N Kasperczyk A Kozłowska A Olewińska E Machoń-Grecka A Kasperczyk S Oxidative DNA damage and oxidative stress in lead-exposed workers Hum Exp Toxicol 201736744 54 10.1177/0960327116665674Open DOISearch in Google Scholar

130Simons T. Lead-calcium interactions and lead toxicity. In: Baker PF, editor. Calcium in drug actions. Handbook of experimental pharmacology. Vol 83. Berlin, Heidelberg: Springer; 1988. p. 509–25. doi: 10.1007/978-3-642-71806-9_24 Simons T Lead-calcium interactions and lead toxicity In Baker PF editor Calcium in drug actions. Handbook of experimental pharmacology. Vol 83. Berlin, Heidelberg Springer 1988 p. 509 25 10.1007/978-3-642-71806-9_24Open DOISearch in Google Scholar

131Rădulescu A, Lundgren S. A pharmacokinetic model of lead absorption and calcium competitive dynamics. Sci Rep 2019;9:14225. doi: 10.1038/s41598-019-50654-7 Rădulescu A Lundgren S A pharmacokinetic model of lead absorption and calcium competitive dynamics Sci Rep 2019914225 10.1038/s41598-019-50654-7Open DOISearch in Google Scholar

132García-Lestón J, Méndez J, Pásaro E, Laffon B. Genotoxic effects of lead: an updated review. Environ Int 2010;36:623–36. doi: 10.1016/j. envint.2010.04.011 García-Lestón J Méndez J Pásaro E Laffon B Genotoxic effects of lead: an updated review Environ Int 201036623 36 10.1016/j. envint.2010.04.011Open DOISearch in Google Scholar

133Sachdeva C, Thakur K, Sharma A, Sharma KK. Lead: tiny but mighty poison. Indian J Clin Biochem 2018;33:132–46. doi: 10.1007/s12291-017-0680-3 Sachdeva C Thakur K Sharma A Sharma KK Lead: tiny but mighty poison Indian J Clin Biochem 201833132 46 10.1007/s12291-017-0680-3Open DOISearch in Google Scholar

134Das U, De M. Chromosomal study on lead exposed population. Int J Hum Genet 2013;13:53–8. doi: 10.1080/09723757.2013.11886197 Das U De M Chromosomal study on lead exposed population Int J Hum Genet 20131353 8 10.1080/09723757.2013.11886197Open DOISearch in Google Scholar

135Pinto D, Ceballos JM, García G, Guzmán P, Del Razo LM, Vera E, Gómez H, García A, Gosebatt ME. Increased cytogenetic damage in outdoor painters. Mutat Res 2000;467:105–11. doi: 10.1016/s1383-5718(00)00024-3 Pinto D Ceballos JM García G Guzmán P Del Razo LM Vera E Gómez H García A Gosebatt ME Increased cytogenetic damage in outdoor painters Mutat Res 2000467105 11 10.1016/s1383-5718(00)00024-3Open DOISearch in Google Scholar

136Rajah T, Ahuja Y. In vivo genotoxic effects of smoking and occupational lead exposure in printing press workers. Toxicol Lett 1995;76:71–5. doi: 10.1016/0378-4274(94)03200-9 Rajah T Ahuja Y In vivo genotoxic effects of smoking and occupational lead exposure in printing press workers Toxicol Lett 19957671 5 10.1016/0378-4274(94)03200-9Open DOISearch in Google Scholar

137Duydu Y, Süzen HS. Influence of δ-aminolevulinic acid dehydratase (ALAD) polymorphism on the frequency of sister chromatid exchange (SCE) and the number of high-frequency cells (HFCs) in lymphocytes from lead-exposed workers. Mutat Res 2003;540:79–88. doi: 10.1016/s1383-5718(03)00172-4 Duydu Y Süzen HS Influence of δ-aminolevulinic acid dehydratase (ALAD) polymorphism on the frequency of sister chromatid exchange (SCE) and the number of high-frequency cells (HFCs) in lymphocytes from lead-exposed workers Mutat Res 200354079 88 10.1016/s1383-5718(03)00172-4Open DOISearch in Google Scholar

138Palus J, Rydzynski K, Dziubaltowska E, Wyszynska K, Natarajan AT, Nilsson R. Genotoxic effects of occupational exposure to lead and cadmium. Mutat Res 2003;540:19–28. doi: 10.1016/S1383-5718(03)00167-0 Palus J Rydzynski K Dziubaltowska E Wyszynska K Natarajan AT Nilsson R Genotoxic effects of occupational exposure to lead and cadmium Mutat Res 200354019 28 10.1016/S1383-5718(03)00167-0Open DOISearch in Google Scholar

139Wiwanitkit V, Suwansaksri J, Soogarun S. White blood cell sister chromatid exchange among a sample of Thai subjects exposed to lead: lead-induced genotoxicity. Toxicol Environ Chem 2008;90:765–8. doi: 10.1080/02772240701712758 Wiwanitkit V Suwansaksri J Soogarun S White blood cell sister chromatid exchange among a sample of Thai subjects exposed to lead: lead-induced genotoxicity Toxicol Environ Chem 200890765 8 10.1080/02772240701712758Open DOISearch in Google Scholar

140Bonassi S, Znaor A, Ceppi M, Lando C, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Ban S, Barale R, Bigatti MP, Bolognesi C, Cebulska-Wasilewska A, Fabianova E, Fucic A, Hagmar L, Joksic G, Martelli A, Migliore L, Mirkova E, Scarfi MR, Zijno A, Norppa H, Fenech M. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 2007;28:625–31. doi: 10.1093/carcin/bgl177 Bonassi S Znaor A Ceppi M Lando C Chang WP Holland N Kirsch-Volders M Zeiger E Ban S Barale R Bigatti MP Bolognesi C Cebulska-Wasilewska A Fabianova E Fucic A Hagmar L Joksic G Martelli A Migliore L Mirkova E Scarfi MR Zijno A Norppa H Fenech M An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans Carcinogenesis 200728625 31 10.1093/carcin/bgl177Open DOISearch in Google Scholar

141Celik A, Öğenler O, Çömelekoğlu Ü. The evaluation of micronucleus frequency by acridine orange fluorescent staining in peripheral blood of rats treated with lead acetate. Mutagenesis 2005;20:411–5. doi: 10.1093/mutage/gei055 Celik A Öğenler O Çömelekoğlu Ü The evaluation of micronucleus frequency by acridine orange fluorescent staining in peripheral blood of rats treated with lead acetate Mutagenesis 200520411 5 10.1093/mutage/gei055Open DOISearch in Google Scholar

142Nersesyan A, Kundi M, Waldherr M, Setayesh T, Mišík M, Wultsch G, Filipic M, Mazzaron Barcelos GR, Knasmueller S. Results of micronucleus assays with individuals who are occupationally and environmentally exposed to mercury, lead and cadmium. Mutat Res Rev Mutat Res 2016;770:119–39. doi: 10.1016/j.mrrev.2016.04.002 Nersesyan A Kundi M Waldherr M Setayesh T Mišík M Wultsch G Filipic M Mazzaron Barcelos GR Knasmueller S Results of micronucleus assays with individuals who are occupationally and environmentally exposed to mercury, lead and cadmium Mutat Res Rev Mutat Res 2016770119 39 10.1016/j.mrrev.2016.04.002Open DOISearch in Google Scholar

143Balasubramanian B, Meyyazhagan A, Chinnappan AJ, Alagamuthu KK, Shanmugam S, Al-Dhabi NA, Mohammed Ghilan AK, Duraipandiyan V, Valan Arasu M. Occupational health hazards on workers exposure to lead (Pb): A genotoxicity analysis. J Infect Public Health 2020;13:527–31. doi: 10.1016/j.jiph.2019.10.005 Balasubramanian B Meyyazhagan A Chinnappan AJ Alagamuthu KK Shanmugam S Al-Dhabi NA Mohammed Ghilan AK Duraipandiyan V Valan Arasu M Occupational health hazards on workers exposure to lead (Pb): A genotoxicity analysis J Infect Public Health 202013527 31 10.1016/j.jiph.2019.10.005Open DOISearch in Google Scholar

144Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2’-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2009;27:120–39. doi: 10.1080/10590500902885684 Valavanidis A Vlachogianni T Fiotakis C 8-hydroxy-2’-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 200927120 39 10.1080/10590500902885684Open DOISearch in Google Scholar

145Liu X, Wu J, Shi W, Shi W, Liu H, Wu X. Lead induces genotoxicity via oxidative stress and promoter methylation of DNA repair genes in human lymphoblastoid TK6 cells. Med Sci Monit 2018;24:4295–304. doi: 10.12659/msm.908425 Liu X Wu J Shi W Shi W Liu H Wu X Lead induces genotoxicity via oxidative stress and promoter methylation of DNA repair genes in human lymphoblastoid TK6 cells Med Sci Monit 2018244295 304 10.12659/msm.908425Open DOISearch in Google Scholar

146Buha A, Baralić K, Djukic-Cosic D, Bulat Z, Tinkov A, Panieri E, Saso L. The role of toxic metals and metalloids in Nrf2 signaling. Antioxidants 2021;10(5):630. doi: 10.3390/antiox10050630 Buha A Baralić K Djukic-Cosic D Bulat Z Tinkov A Panieri E Saso L The role of toxic metals and metalloids in Nrf2 signaling Antioxidants 2021105630 10.3390/antiox10050630Open DOISearch in Google Scholar

147Aglan HS, Gebremedhn S, Salilew-Wondim D, Neuhof C, Tholen E, Holker M, Schellander K, Tesfaye D. Regulation of Nrf2 and NF-κB during lead toxicity in bovine granulosa cells. Cell Tissue Res 2020;380:643–55. doi: 10.1007/s00441-020-03177-x Aglan HS Gebremedhn S Salilew-Wondim D Neuhof C Tholen E Holker M Schellander K Tesfaye D Regulation of Nrf2 and NF-κB during lead toxicity in bovine granulosa cells Cell Tissue Res 2020380643 55 10.1007/s00441-020-03177-xOpen DOISearch in Google Scholar

148Alotaibi MF, Al-Joufi F, Abou Seif HS, Alzoghaibi MA, Djouhri L, Ahmeda AF, Mahmoud AM. Umbelliferone inhibits spermatogenic defects and testicular injury in lead-intoxicated rats by suppressing oxidative stress and inflammation, and improving Nrf2/HO-1 signaling. Drug Des Devel Ther 2020;14:4003–19. doi: 10.2147/dddt.s265636 Alotaibi MF Al-Joufi F Abou Seif HS Alzoghaibi MA Djouhri L Ahmeda AF Mahmoud AM Umbelliferone inhibits spermatogenic defects and testicular injury in lead-intoxicated rats by suppressing oxidative stress and inflammation, and improving Nrf2/HO-1 signaling Drug Des Devel Ther 2020144003 19 10.2147/dddt.s265636Open DOISearch in Google Scholar

149World Health Organization, International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Inorganic and Organic Lead Compounds. Vol. 87. Inorganic and Organic Lead, 2006 [displayed 28 October 2022]. Available at https://monographs.iarc.who.int/wp-content/uploads/2018/06/mono87.pdf World Health Organization, International Agency for Research on Cancer IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Inorganic and Organic Lead Compounds. Vol. 87. Inorganic and Organic Lead, 2006 [displayed 28 October 2022]. Available at https://monographs.iarc.who.int/wp-content/uploads/2018/06/mono87.pdfSearch in Google Scholar

150Wallace DR, Djordjevic AB. Heavy metal and pesticide exposure: A mixture of potential toxicity and carcinogenicity. Curr Opin Toxicol 2020;19:72–9. 10.1016/j.cotox.2020.01.001 Wallace DR Djordjevic AB Heavy metal and pesticide exposure: A mixture of potential toxicity and carcinogenicity Curr Opin Toxicol 20201972 9 10.1016/j.cotox.2020.01.001Open DOISearch in Google Scholar

151Chen QY, DesMarais T, Costa M. Metals and mechanisms of carcinogenesis. Annu Rev Pharmacol Toxicol 2019;59:537–54. doi: 10.1146/annurev-pharmtox-010818-021031 Chen QY DesMarais T Costa M Metals and mechanisms of carcinogenesis Annu Rev Pharmacol Toxicol 201959537 54 10.1146/annurev-pharmtox-010818-021031Open DOISearch in Google Scholar

152Fraga CG, Onuki J, Lucesoli F, Bechara EJ, Di Mascio P. 5-Aminolevulinic acid mediates the in vivo and in vitro formation of 8-hydroxy-2’-deoxyguanosine in DNA. Carcinogenesis 1994;15:2241–4. doi: 10.1093/carcin/15.10.2241 Fraga CG Onuki J Lucesoli F Bechara EJ Di Mascio P 5-Aminolevulinic acid mediates the in vivo and in vitro formation of 8-hydroxy-2’-deoxyguanosine in DNA Carcinogenesis 1994152241 4 10.1093/carcin/15.10.2241Open DOISearch in Google Scholar

153Xu X, Liao W, Lin Y, Dai Y, Shi Z, Huo X. Blood concentrations of lead, cadmium, mercury and their association with biomarkers of DNA oxidative damage in preschool children living in an e-waste recycling area. Environ Geochem Health 2018;40:1481–94. doi: 10.1007/s10653-017-9997-3 Xu X Liao W Lin Y Dai Y Shi Z Huo X Blood concentrations of lead, cadmium, mercury and their association with biomarkers of DNA oxidative damage in preschool children living in an e-waste recycling area Environ Geochem Health 2018401481 94 10.1007/s10653-017-9997-3Open DOISearch in Google Scholar

154Gorini F, Scala G, Cooke MS, Majello B, Amente S. Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: highlighting the intertwined roles of DNA damage and epigenetics in genomic instability. DNA Repair 2021;97:103027. doi: 10.1016/j.dnarep.2020.103027 Gorini F Scala G Cooke MS Majello B Amente S Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: highlighting the intertwined roles of DNA damage and epigenetics in genomic instability DNA Repair 202197103027 10.1016/j.dnarep.2020.103027Open DOISearch in Google Scholar

155Cogoi S, Ferino A, Miglietta G, Pedersen EB, Xodo LE. The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription. Nucleic Acids Res 2018;46:661–76. doi: 10.1093/nar/gkx1142 Cogoi S Ferino A Miglietta G Pedersen EB Xodo LE The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription Nucleic Acids Res 201846661 76 10.1093/nar/gkx1142Open DOISearch in Google Scholar

156Fleming AM, Ding Y, Burrows CJ. Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair. Proc Natl Acad Sci USA 2017;114:2604–9. doi: 10.1073/pnas.1619809114 Fleming AM Ding Y Burrows CJ Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair Proc Natl Acad Sci USA 20171142604 9 10.1073/pnas.1619809114Open DOISearch in Google Scholar

157Giorgio M, Dellino GI, Gambino V, Roda N, Pelicci PG. On the epigenetic role of guanosine oxidation. Redox Biol 2020;29:101398. doi: 10.1016/j.redox.2019.101398 Giorgio M Dellino GI Gambino V Roda N Pelicci PG On the epigenetic role of guanosine oxidation Redox Biol 202029101398 10.1016/j.redox.2019.101398Open DOISearch in Google Scholar