Joint impact of key air pollutants on COVID-19 severity: prediction based on toxicogenomic data analysis
, , , , , , , , and | Jul 07, 2022
About this article
Article Category: Original article
Published Online: Jul 07, 2022
Page range: 119 - 125
Received: Feb 01, 2022
Accepted: May 01, 2022
DOI: https://doi.org/10.2478/aiht-2022-73-3631
© 2022 Danijela Đukić-Ćosić, Katarina Baralić, Teodora Filipović, Dragica Božić, Katarina Živančević, Evica Antonijević Miljaković, Aleksandra Buha Đorđević, Zorica Bulat, Biljana Antonijević, and Marijana Ćurčić, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1
Figure 2
Influence of air pollutants (SO2, CO, PMx, NO2 and O3) on protein secretion, mRNA expression, and protein expression of genes related to these air pollutants and COVID-19 disease complications (CTD Database; http://CTD.mdibl.org)
| Air pollutant | Interaction | ||||
|---|---|---|---|---|---|
| Protein secretion | ↑ | ||||
| mRNA expression | |||||
| Protein expression | ↑ | ↑ | ↑ | ||
| Protein secretion | ↑ | ||||
| mRNA expression | ↑ | ||||
| Protein expression | ↑ | ↑ | ↑↓ | ↑↓ | |
| Protein secretion | ↑↓ | ↑ | ↑ | ↑ | |
| mRNA expression | ↑↓ | ↑↓ | ↑↓ | ||
| Protein expression | ↑↓ | ↑ | ↑↓ | ↑↓ | |
| Protein secretion | ↑ | ↓ | |||
| mRNA expression | ↑ | ↑↓ | ↓ | ↑ | |
| Protein expression | ↑ | ↑ | ↑ | ↑ | |
| Protein secretion | ↑ | ↑ | |||
| mRNA expression | ↓ | ↑ | ↑↓ | ↓ | |
| Protein expression | ↓ | ↑ | ↑↓ | ↑↓ |
Top 10 gene-disease pairs for genes related to both COVID-19 complications and air pollutants, along with the 20 predicted genes (DisGeNET database; http://www.disgenet.org)
| Gene | Disease | Disease class (DisGeNET) | Score |
|---|---|---|---|
| acute myelocytic leukaemia | neoplasms | 1.000 | |
| TNF receptor-associated periodic fever syndrome (TRAPS) | pathological conditions, signs and symptoms; congenital, hereditary, and neonatal diseases and abnormalities; skin and connective tissue diseases | 1.000 | |
| familial Behcet-like autoinflammatory syndrome | / | 0.710 | |
| rheumatoid arthritis | skin and connective tissue diseases; musculoskeletal diseases; immune system diseases | 0.700 | |
| inflammatory bowel diseases | digestive system diseases | 0.700 | |
| systemic lupus erythematosus, systemic | skin and connective tissue diseases diseases; immune system | 0.700 | |
| Crohn's disease | digestive system diseases | 0.700 | |
| fever | pathological conditions, signs and symptoms | 0.700 | |
| systemic lupus erythematosus | skin and connective tissue diseases; immune system diseases | 0.700 | |
| amyotrophic lateral sclerosis | nutritional and metabolic diseases diseases; nervous system | 0.700 |