1. bookVolume 70 (2019): Issue 3 (September 2019)
Journal Details
First Published
26 Mar 2007
Publication timeframe
4 times per year
access type Open Access

Chemical composition and antioxidant, cytotoxic, and insecticidal potential of Valeriana alliariifolia in Turkey

Published Online: 30 Sep 2019
Page range: 207 - 218
Received: 01 Mar 2019
Accepted: 01 Sep 2019
Journal Details
First Published
26 Mar 2007
Publication timeframe
4 times per year

1. Richardson IBK. Valeriana. In: Davis PH, editor. Flora of Turkey and the East Aegean islands. Vol. 4. Edinburgh: Edinburgh University Press; 1972. p. 551–8.Search in Google Scholar

2. Davis PH, editor. Flora of Turkey and the East Aegean islands. Vol. 10. Supplement I. Edinburgh: Edinburgh University Press; 1988.Search in Google Scholar

3. Güner A, Özhatay N, Ekim T, Başer KHC, editors. Flora of Turkey and the east aegean islands. Vol. 11. Edinburgh: Edinburgh University Press; 2008.Search in Google Scholar

4. Taherpour AA, Maroofi H, Bajelani O, Larijani K. Chemical composition of the essential oil of Valeriana alliariifolia Adams of Iran. Nat Prod Res 2010;24:973–8. doi: 10.1080/1478641090290001020496237Search in Google Scholar

5. Aslan S. Valeriana L. In: Güner A, Aslan S, Ekim T, Vural M, Babac MT, editors. Turkiye bitkileri listesi (damarli bitkiler) [List of Turkish Flora (vascular plants), in Turkish]. Istanbul: Nezahat Gokyigit Botanik Bahcesi ve Flora Arastirmalari Dernegi Yayini; 2012. p. 322–5.Search in Google Scholar

6. Baytop T. Türkiye’de Bitkiler Ile Tedavi (Geçmişte ve Bugün) [Therapy with medicinal plants in Turkey (past and present), in Turkish]. Istanbul: Nobel Tip Kitapevleri Ltd Sti; 1999.Search in Google Scholar

7. Bos R, Woerdenbag HJ, van Putten FMS, Hendriks H, Scheffer JJC. Seasonal variation of the essential oil, valerenic acid and derivatives, and velopotriates in Valeriana officinalis roots and rhizomes, and the selection of plants suitable for phytomedicines. Planta Med 1998;64:143–7. doi: 10.1055/s-2006-95739210.1055/s-2006-95739295564409556440Open DOISearch in Google Scholar

8. Wang Y, Jin L, Yu S, Shi Q, Gu Y, Kiyota H. Chemical constituents of plants from the genus Valeriana. Mini-Rev Org Chem 2010;7:161–72. doi: 10.2174/15701931079106553710.2174/157019310791065537Search in Google Scholar

9. Şen B, Mat A. Chemical and medicinal evaluations of the Valeriana species in Turkey. J Fac Pharm Istanbul 2015;45:267–76.Search in Google Scholar

10. Xu K, Lin Y, Zhang R, Lan M, Chen C, Li S, Zuo C, Chen C, Zhang T, Yan Z. Evaluation of safety of iridoids rich fraction from Valeriana jatamansi Jones: Acute and sub-chronic toxicity study in mice and rats. J Ethnopharmacol 2015;172:386–94. doi: 10.1016/j.jep.2015.06.04610.1016/j.jep.2015.06.04626164073Search in Google Scholar

11. Aydın F, Yurdakok Dikmen B, Kismali G. The potential cytotoxic effects of Valeriana officinalis extract on prostate cancer cell lines DU-145 and PC-3. Toxicol Lett 2016;258(Supplement):S299. doi: 10.1016/j.toxlet.2016.06.203710.1016/j.toxlet.2016.06.2037Open DOISearch in Google Scholar

12. Lin S, Zhang Z-X, Chen T, Ye J, Dai W-X, Shan L, Su J, Shen Y-H, Li H-L, Liu R-H, Xu X-K, Wang H, Zhang W-D. Characterization of chlorinated valepotriates from Valeriana jatamansi. Phytochemistry 2013;85:185–93. doi: 10.1016/j.phytochem.2012.08.01510.1016/j.phytochem.2012.08.01523036722Open DOISearch in Google Scholar

13. Wang R-J, Chen H-M, Yang F, Deng Y, Ao H, Xie X-F, Li H-X, Zhang H, Cao Z-X, Zhu L-X, Chen Y, Peng C, Tan Y-Z. Iridoids from the roots of Valeriana jatamansi Jones. Phytochemistry 2017;141:156–61. doi: 10.1016/j.phytochem.2017.05.01010.1016/j.phytochem.2017.05.01028623738Open DOISearch in Google Scholar

14. Kırmızıbekmez H, Kúsz N, Bérdi P, Zupkó I, Hohmann J. New iridoids from the roots of Valeriana dioscoridis Sm. Fitoterapia 2018;130:73–8. doi: 10.1016/j.fitote.2018.08.00710.1016/j.fitote.2018.08.00730138654Search in Google Scholar

15. Liu Y-H, Wu P-Q, Hu Q-L, Pei Y-J, Qi F-M, Zhang Z-X, Fei D-Q. Cytotoxic and antibacterial activities of iridoids and sesquiterpenoids from Valeriana jatamansi. Fitoterapia 2017;123:73–8. doi: 10.1016/j.fitote.2017.09.01110.1016/j.fitote.2017.09.01128941743Search in Google Scholar

16. Dua, VK, Alam MF, Pandey AC, Rai S, Chopra AK, Kaul VK, Dash AP. Insecticidal activity of Valeriana jatamansi (Valerianaceae) Against Mosquitoes. J Am Mosq Control Assoc 2008;24:315–8. doi: 10.2987/5642.110.2987/5642.118666542Search in Google Scholar

17. Tan Y-Z, Yong Y, Dong Y-H, Wang R-J, Li H-X, Zhang H, Guo D-L, Zhang S-J, Dong X-P, Xie X-F. A new secoiridoid glycoside and a new sesquiterpenoid glycoside from Valeriana jatamansi with neuroprotective activity. Phytochem Lett 2016;17:177–80. doi: 10.1016/j.phytol.2016.07.02010.1016/j.phytol.2016.07.020Open DOISearch in Google Scholar

18. Bardakçı H, Demirci B, Yeşilada E, Kırmızıbekmez H, Başer, KHC. Chemical composition of the essential oil of the subterranean parts of Valeriana alliariifolia. Rec Nat Prod 2012;6:89–92.Search in Google Scholar

19. Özgökçe F. Özçelik H. Ethnobotanical aspects of some Anatolia, Turkey. Econ Bot 2004;58:697–704. doi: 10.1663/0013-0001(2004)058[0697:EAOSTI]2.0.CO;210.1663/0013-0001(2004)058[0697:EAOSTI]2.0.CO;2Open DOISearch in Google Scholar

20. Oz-Aydın S, Dirmenci T, Tumen G, Başer KHC. Plants used as analgesic in the folk medicine of Turkey. In: Ertug ZF, editor. Proceedings of the IVth International Congress of Ethnobotany (ICEB, 2005); 21–26 August 2005; Istanbul, Turkey. Istanbul: Yeditepe University; 2006. p. 167–71.Search in Google Scholar

21. Fakir H, Korkmaz M, Güller B. Medicinal plant diversity of western Mediterranean region in Turkey. JABS 2009;3:33–43.Search in Google Scholar

22. Kaya DA. [Çukurova bölgesinde farklı sıra arası ve hasat zamanlarında kediotu (Valeriana officinalis L.) bitkisinin verim ve uçucu yağ kalitesinin araştırılması, in Turkish]. [PhD Thesis]. Adana: Cukurova University; 2006.Search in Google Scholar

23. Özbay O, Aslan S, Kartal M, Kurucu S, Bos R, Woerdenbag HJ, Kayser O. Preliminary examination of the composition of the essential oil from the roots and rhizomes of Valeriana alpestris Stev. growing in Turkey. J Essent Oil Res 2009;21:555–7. doi: 10.1080/10412905.2009.970024310.1080/10412905.2009.9700243Open DOISearch in Google Scholar

24. Aslan S, Kartal M, Kurucu S, Kuiper JM, Kruizinga WH, Bos R, Woerdenbag HJ, Kayser O. Composition of the essential oil from roots and rhizomes of Valeriana phu L. growing wild in Turkey. J Essent Oil Res 2009;21:437–40. doi: 10.1080/10412905.2009.970021210.1080/10412905.2009.9700212Open DOISearch in Google Scholar

25. Ebrahimzadeh H, Radjabian T, Tousi AE, Nikham V, Mozaffarian V. Evaluation of some Iranian wild species from Valerianaceae as commercial sources of valepotriates. J Biol Sci 2008;8:549–55. doi: 10.3923/jbs.2008.549.55510.3923/jbs.2008.549.555Search in Google Scholar

26. Samaneh ET, Tayebeh R, Hassan E, Vahid N. Composition of essential oils in subterranean organs of three species of Valeriana L. Nat Prod Res 2010;24:1834–42. doi: 10.1080/14786419.2010.48205110.1080/14786419.2010.482051Open DOISearch in Google Scholar

27. Ozdemir A, Turkoglu V, Demir H. In vitro effect of some plant extracts on acetylcholinesterase enzyme in human erythrocytes and serum. Fresen Environ Bull 2013;22:2510–5.Search in Google Scholar

28. Karadeniz A, Çinbilgel I, Gün SŞ, Çetin A. Antioxidant activity of some Turkish medicinal plants. Nat Prod Res 2015;29:2308–12. doi: 10.1080/14786419.2015.100561810.1080/14786419.2015.1005618Open DOISearch in Google Scholar

29. Fu W, Chen J, Cai Y, Lei Y, Chen L, Pei L, Zhou D, Liang X, Ruan J. Antioxidant, free radicalscavenging, anti-inflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica (Franch.et Sav.) Ching. J Ethnopharmacol 2010;130:521–8. doi: 10.1016/j.jep.2010.05.03910.1016/j.jep.2010.05.039Search in Google Scholar

30. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 1999;26:1231–7. doi: 10.1016/s0891-5849(98)00315-310.1016/S0891-5849(98)00315-3Open DOISearch in Google Scholar

31. Taşkın T, Çam ME, Taşkın D, Rayaman E. In vitro and In vivo biological activities and phenolic characterization of Thymus praecox subsp. skorpilii var. skorpilii. J Food Meas Charact 2019;13:536–44. doi: 10.1007/s11694-018-9967-110.1007/s11694-018-9967-1Open DOISearch in Google Scholar

32. Şen B, Kessler S, Gürdal B, Kiemer A, Mat A. The difference between the extracts of Erica manipuliflora in flowering and fruiting periods in terms of the cytotoxic effects. J Fac Pharm Istanbul Univ 2016;46:71–8.Search in Google Scholar

33. Kessler SM, Pokorny J, Zimmer V, Laggai S, Lammert F, Bohle RM, Kiemer AK. IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling. Am J Physiol Gastrointest Liver Physiol 2013;304:G328–36. doi: 10.1152/ajpgi.00005.201210.1152/ajpgi.00005.2012Open DOISearch in Google Scholar

34. Kiemer AK, Weber NC, Fürst R, Bildner N, Kulhanek-Heinze S, Vollmar AM. Inhibition of p38 MAPK Activation via Induction of MKP-1: atrial natriuretic peptide reduces TNF-α-induced actin polymerization and endothelial permeability. Circ Res 2002;90:874–81. doi: 10.1161/01.res.0000017068.58856.f310.1161/01.RES.0000017068.58856.F3Open DOISearch in Google Scholar

35. Diesel B, Ripoche N, Risch RT, Tierling S, Walter J, Kiemer AK. Inflammation-induced up-regulation of TLR2 expression in human endothelial cells is independent of differential methylation in the TLR2 promoter CpG island. Innate Immun 2011;18:112–23. doi: 10.1177/175342591039488810.1177/1753425910394888Open DOISearch in Google Scholar

36. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55–63. doi: 10.1016/0022-1759(83)90303-410.1016/0022-1759(83)90303-46606682Open DOISearch in Google Scholar

37. Tabanca N, Bernier UR, Agramonte NM, Tsikolia M, Bloomquist JR. Discovery of repellents from natural products. Curr Org Chem 2016;20:2690–702. doi: 10.2174/138527282066616042115150310.2174/1385272820666160421151503Open DOISearch in Google Scholar

38. Pridgeon JW, Pereira RM, Becnel JJ, Allan SA, Clark GG, Linthicum KJ. Susceptibility of Aedes aegypti, Culex quinquefasciatus Say, and Anopheles quadrimaculatus Say to 19 pesticides with different modes of action. J Med Entomol 2008;45:82–7. doi: 10.1093/jmedent/45.1.8210.1093/jmedent/45.1.82Open DOISearch in Google Scholar

39. Masi M, Cimmino A, Tabanca N, Becnel JJ, Bloomquist JR, Evidente A. A survey of bacterial, fungal and plant metabolites against Aedes aegypti (Diptera: Culicidae), the vector of yellow and dengue fevers and Zika virus. Open Chem 2017;15:156–66. doi: 10.1515/chem-2017-001910.1515/chem-2017-0019Open DOISearch in Google Scholar

40. Adams RP. Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry. 4th ed. Carol Stream (IL): Allured Publishing Corporation; 2007.Search in Google Scholar

41. Hochmuth DH. MassFinder-4. Hamburg: Hochmuth Scientific Consulting; 2008.10.32473/edis-hs338-2007Search in Google Scholar

42. McLafferty FW, Stauffer DB. The Wiley/NBS Registry of Mass Spectral Data. New York: J. Wiley and Sons; 1989.Search in Google Scholar

43. Göger F, Köse YB, Göger G, Demirci F. Phytochemical characterization of phenolics by LC-MS/MS and biological evaluation of Ajuga orientalis from Turkey. Bangladesh J Pharmacol 2015;10:639–44. doi: 10.3329/bjp.v10i3.2350010.3329/bjp.v10i3.23500Search in Google Scholar

44. Navarrete A, Avula B, Choi Y-W, Khan IA. Chemical fingerprinting of Valeriana species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection. J AOAC Int 2006;89:8–15. PMID: 1651222210.1093/jaoac/89.1.8Search in Google Scholar

45. Marder M, Viola H, Wasowski C, Fernández S, Medina JH, Paladini AC. 6-Methylapigenin and hesperidin: new Valeriana flavonoids with activity on the CNS. Pharmacol Biochem Behav 2003;75:537–45. doi: 10.1016/s0091-3057(03)00121-710.1016/s0091-3057(03)00121-7Open DOISearch in Google Scholar

46. Meinhart AD, Damin FM, Caldeirão L, da Silveira TFF, Filho JT, Godoy HT. Chlorogenic acid isomer contents in 100 plants commercialized in Brazil. Food Res Int 2017;99:522–30. doi: 10.1016/j.foodres.2017.06.01710.1016/j.foodres.2017.06.017Open DOISearch in Google Scholar

47. Helmja K. Determination of phenolic compounds and their antioxidative capability in plant extracts. [PhD thesis]. Tallinn: Tallinn University of Technology; 2010.Search in Google Scholar

48. Wang P, Kang J, Zheng R, Yang Z, Lu J, Gao J, Jia, Z. Scavenging effects of phenylpropanoid glycosides from Pedicularis on superoxide anion and hydroxyl radical by Spin trapping method(95)02255–4. Biochem Pharmacol 1996;51:687–91. doi: 10.1016/S0006-2952(95)02255-410.1016/S0006-2952(95)02255-4Open DOISearch in Google Scholar

49. Aleo E, Ricci R, Passi S, Cataudella S. A novel cyt C-H2O2-chemiluminescence assay for measuring the reducing/antioxidant capacity of a wide range of hydrophilic and lipophilic antioxidants and biological samples. Prog Nutr 2005;3:154–82.Search in Google Scholar

50. Funes L, Fernández-Arroyo S, Laporta O, Pons A, Roche E, Segura-Carretero A, Fernández-Gutiérrez A, Micol V. Correlation between plasma antioxidant capacity and verbascoside levels in rats after oral administration of lemon verbena extract. Food Chem 2009;117:589–98. doi: 10.1016/j.foodchem.2009.04.05910.1016/j.foodchem.2009.04.059Open DOISearch in Google Scholar

51. Hung TM, Na M, Thuong PT, Su ND, Sok D, Song KS, Seong YH, Bae K. Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall. J Ethnopharmacol 2006;108:188–92. doi: 10.1016/j.jep.2006.04.02910.1016/j.jep.2006.04.029Open DOISearch in Google Scholar

52. Jung HA, Park JC, Chung HY, Kim J, Choi JS. Antioxidant flavonoids and chlorogenic acid from the leaves of Eriobotrya japonica. Arch Pharm Res 1999;22:213–8. doi: 10.1007/BF0297654910230515Search in Google Scholar

53. Wilmsen PK, Spada DS, Salvador M. Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J Agric Food Chem 2005;53:4757–61. doi: 10.1021/jf050200010.1021/jf0502000Open DOISearch in Google Scholar

54. Wang J, Lou J, Luo C, Zhou L, Wang M, Wang L. Phenolic compounds from Halimodendron halodendron (Pall.) voss and their antimicrobial and antioxidant activities. Int J Mol Sci 2012;13:11349–64. doi: 10.3390/ijms13091134910.3390/ijms13091134923109858Open DOISearch in Google Scholar

55. Scragg MA, Cannon SJ, Williams DM. Comparative cytotoxic effects of short-chain fatty acids produced by periodontal pathogens on two cultured fibroblast line. Microb Ecol Health Dis 1994;7:83–90. doi: 10.3109/0891060940914157610.3109/08910609409141576Open DOISearch in Google Scholar

56. Bos R, Hendriks H, Scheffer JJC, Woerdenbag HJ. Cytotoxic potential of valerian constituents and valerian tinctures. Phytomedicine 1998;5:219–25. doi: 10.1016/S0944-7113(98)80032-910.1016/S0944-7113(98)80032-9Open DOISearch in Google Scholar

57. Russo R, Ciociaro A, Berliocchi L, Cassiano MG, Rombolà L, Ragusa S, Bagetta G, Blandini F, Corasaniti MT. Implication of limonene and linalyl acetate in cytotoxicity induced by bergamot essential oil in human neuroblastoma cells. Fitoterapia 2013;89:48–57. doi: 10.1016/j.fitote.2013.05.0142370774410.1016/j.fitote.2013.05.01423707744Search in Google Scholar

58. Manassero CA, Girotti JR, Mijailovsky S, García de Bravo M, Polo M. In vitro comparative analysis of antiproliferative activity of essential oil from mandarin peel and its principal component limonene. Nat Prod Res 2013;27:1475–8. doi: 10.1080/14786419.2012.71877522943501Search in Google Scholar

59. Al-Gendy AA, El-Sayed MA, Hamdan DI, El-Shazly AM. Volatile constituents, antimicrobial and cytotoxic activities of citrus reticulata Blanco Cultivar Murcott. Int J Pharmacogn Phytochem 2017;9:376–86. doi: 10.25258/phyto.v9i2.808910.25258/phyto.v9i2.8089Open DOISearch in Google Scholar

60. Sivropoulou A, Papanikolaou E, Nikolaou C, Kokkini S, Lanaras T, Arsenakis M. Antimicrobial and cytotoxic activities of Origanum essential oils. J Agric Food Chem 1996;44:1202–5. doi: 10.1021/jf950540t10.1021/jf950540tOpen DOISearch in Google Scholar

61. Mehdi SJ, Ahmad A, Irshad M, Manzoor N, Rizvi MMA. Cytotoxic effect of carvacrol on human cervical cancer cells. Biol Med 2011;3:307–12. doi: 10.4172/0974-8369.1000011910.4172/0974-8369.10000119Open DOISearch in Google Scholar

62. Llana-Ruiz-Cabello M, Gutiérrez-Praena D, Pichardo S, Moreno FJ, Bermúdez JM, Aucejo S, Cameán AM. Cytotoxicity and morphological effects induced by carvacrol and thymol on the human cell line Caco-2. Food Chem Toxicol 2014;64:281–90. doi: 10.1016/j.fct.2013.12.00510.1016/j.fct.2013.12.005Open DOISearch in Google Scholar

63. Coccimiglio J, Alipour M, Jiang ZH, Gottardo C, Suntres Z. Antioxidant, antibacterial, and cytotoxic activities of the ethanolic Origanum vulgare extract and its major constituents. Oxid Med Cell Longev 2016;2016:ID1404505. doi: 10.1155/2016/140450510.1155/2016/1404505Search in Google Scholar

64. Al-Fatlawi AA, Rahisuddin, Ahmad A. Cytotoxicity and pro-apoptotic activity of carvacrol on human breast cancer cell line MCF-7. World J Pharm Sci 2014;2:1218–23.Search in Google Scholar

65. Loizzo MR, Tundis R, Menichini F, Saab AM, Statti GA, Menichini F. Cytotoxic activity of essential oils from labiatae and lauraceae families against in vitro human tumor models. Anticancer Res 2007;27(5A):3293–9. PMID: 17970073Search in Google Scholar

66. Sampath S, Veeramani V, Krishnakumar GS, Sivalingam U, Madurai SL, Chellan R. Evaluation of in vitro anticancer activity of 1,8-cineole-containing n-hexane extract of Callistemon citrinus (Curtis) Skeels plant and its apoptotic potential. Biomed Pharmacother 2017;93:296–307. doi: 10.1016/j.biopha.2017.06.05610.1016/j.biopha.2017.06.056Open DOISearch in Google Scholar

67. Saracoglu I, Inoue M, Calis I, Ogihara Y. Studies on constituents with cytotoxic and cytostatic activity of two Turkish medicinal plants Phlomis armeniaca and Scutellaria salviifolia. Biol Pharm Bull 1995;18:1396–400. doi: 10.1248/bpb.18.139610.1248/bpb.18.1396Open DOISearch in Google Scholar

68. Harput US, Genc Y, Saracoglu I. Cytotoxic and antioxidative activities of Plantago lagopus L. and characterization of its bioactive compounds. Food Chem Toxicol 2012;50:1554–9. doi: 10.1016/j.fct.2012.01.01910.1016/j.fct.2012.01.019Open DOISearch in Google Scholar

69. Jiang Y, Kusama K, Satoh K, Takayama E, Watanabe S, Sakagami H. Induction of cytotoxicity by chlorogenic acid in human oral tumor cell lines. Phytomedicine 2000;7:483–91. doi: 10.1016/S0944-7113(00)80034-310.1016/S0944-7113(00)80034-3Open DOISearch in Google Scholar

70. Natarajan N, Thamaraseivan R, Lingaiah H, Srinivasan P, Periyasamy BM. Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7. Biomed Prevent Nutr 2011;1:207–15. doi: 10.1016/j.bionut.2011.07.00110.1016/j.bionut.2011.07.001Open DOISearch in Google Scholar

71. Banjerdpongchai R, Wudtiwai B, Khaw-On P, Rachakhom W, Duangnil N, Kongtawelert P. Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways. Tumour Biol 2016;37:227–37. doi: 10.1007/s13277-015-3774-710.1007/s13277-015-3774-7484185426194866Open DOISearch in Google Scholar

72. Yamauchi K, Mitsunaga T, Afroze SH, Uddin MN. Structure-activity relationships of methylquercetin on anti-migration and anti-proliferation activity in B16 melanoma cells. Anticancer Res 2017;37:1575–9. doi: 10.21873/anticanres.1148710.21873/anticanres.11487Open DOISearch in Google Scholar

73. Sak K, Lust H, Kase M, Jaal J. Cytotoxic action of methylquercetins in human lung adenocarcinoma cells. Oncol Lett 2018;15:1973–8. doi: 10.3892/ol.2017.746610.3892/ol.2017.7466Search in Google Scholar

74. Chantraine J-M, Laurent D, Ballivian C, Saavedra G, Ibanez R, Vilaseca A. Insecticidal activity of essential oils on Aedes aepgyti larvae. Phytother Res 1998;12:350–4. doi: 10.1002/(SICI)1099-1573(199808)12:5<350::AIDPTR311>3.0.CO;2-710.1002/(SICI)1099-1573(199808)12:5<350::AIDPTR311>3.0.CO;2-7Open DOISearch in Google Scholar

75. Santos SRL, Melo MA, Cardoso AV, Santos RLC, de Sousa DP, Cavalcanti SCH. Structure-activity relationships of larvicidal monoterpenes and derivatives against Aedes aegypti Linn. Chemosphere 2011;84:150–3. doi: 10.1016/j.chemosphere.2011.02.01810.1016/j.chemosphere.2011.02.018Open DOISearch in Google Scholar

76. Silva WJ, Dória GA, Maia RT, Nunes RS, Carvalho GA, Blank AF, Alves PB, Marçal RM, Cavalcanti SCH. Effects of essential oils on Aedes aegypti larvae: alternatives to environmentally safe insecticides. Bioresour Technol 2008;99:3251–5. doi: 10.1016/j.biortech.2007.05.06410.1016/j.biortech.2007.05.064Open DOISearch in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo