Open Access

Antihelminic Activity of Carvacrol, Thymol, Cinnamaldehyde and P-Cymen Against the Free-Living Nematode Caenorhabditis elegans and Rat Pinworm Syphacia muris


Cite

1. Hugot JP, Aujard P, Morand S: Biodiversity in helminths and nematodes as a field of study: an overview. Nernatology. 2001, 3(3): 199-208.Search in Google Scholar

2. Trailović SM, Marjanović DS, Nedeljković Trailović J, Robertson AP, Martin RJ: Interaction of carvacrol with the Ascaris suum nicotinic acetylcholine receptors and gamma-aminobutyric acid receptors, potential mechanism of antinematodal action. Parasitol Res. 2015, 114(8):3059-68.10.1007/s00436-015-4508-x460727725944741Search in Google Scholar

3. Ribeiro JC, Ribeiro WLC, Camurça-Vasconcelos ALF, Macedo ITF, Santos JML, Paula HCB: Efficacy of free and nanoencapsulated Eucalyptus citriodora essential oils on sheep gastrointestinal nematodes and toxicity for mice. Vet Parasitol. 2014, 204(3-4):243-248.10.1016/j.vetpar.2014.05.02624929446Search in Google Scholar

4. Kaminsky RA: New class of anthelmintics effective against drug-resistant nematodes. Nature. 2008, 452:176-180.10.1038/nature0672218337814Search in Google Scholar

5. Holden-Dye L, Walker RJ. Anthelmintic Drugs. In: The C. elegans Research Community, WormBook http://www.wormbook.org. 2007, pp. 1-13.10.1895/wormbook.1.143.1478134817988075Search in Google Scholar

6. Simpkin, KG, Coles GC: The use of Caenorhabditis elegans for anthelmintic screening. J Chem Tech Biotechnol. 1981, 31:66–69.10.1002/jctb.280310110Search in Google Scholar

7. Baker DG; Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev. 1998, 11:231-66.10.1128/CMR.11.2.2311068329564563Search in Google Scholar

8. Owen DC: Parasites of Laboratory Animals, Laboratory Animal Handbooks No12. London: Royal Society of Medicine Services Limited. 1992.Search in Google Scholar

9. Lewis, JW, d’Silva J: The life-cycle of Syphaciamuris Yamaguti (Nematoda: Oxyuroidea) in the laboratory rat. J Helminthol. 1986, 60:39-46.10.1017/S0022149X00008208Search in Google Scholar

10. Meade TM, Watson J: Characterization of rat pinworm (Syphacia muris) epidemiology as a means to increase detection and elimination. J Am Assoc Lab Anim Sci. 2014, 53(6):661-7.Search in Google Scholar

11. Williams AR, Ramsay A, Hansen TV, Ropiak HM, Mejer H, Nejsum P, Mueller-Harvey I, Thamsborg SM: Anthelmintic activity of trans-cinnamaldehyde and A- and B-type proanthocyanidins derived from cinnamon (Cinnamomum verum). Sci Rep. 2015, 5: 14791.10.1038/srep14791458856526420588Search in Google Scholar

12. Andre WP, Ribeiro WL, Cavalcante GS, dos Santos JM, Macedo IT, de Paula HC, de Freitas RM, de Morais SM, de Melo JV, Bevilaqua CM: Comparative efficacy and toxic effects of carvacryl acetate and carvacrol on sheep gastrointestinal nematodes and mice. Vet Parasitol. 2016, 218:52-8.10.1016/j.vetpar.2016.01.00126872928Search in Google Scholar

13. Maggiore M, Pensel PE, Denegri G, Elissondo MC: Chemoprophylactic and therapeutic efficacy of thymol in murine cystic echinococcosis. Parasitol Int. 2015, 64(5):435-40.10.1016/j.parint.2015.06.00526096310Search in Google Scholar

14. Kaplan RM, Storey BE, Vidyashankar AN, Bissinger BW, Mitchell SM, Howell SB, Mason ME, Lee MD, Pedroso AA, Akashe A, Skrypec DJ: Antiparasitic efficacy of a novel plant based functional food using an Ascaris suum model in pigs. Acta Trop. 2014, 139:15-22.10.1016/j.actatropica.2014.06.00824979686Search in Google Scholar

15. Willis HH: A simple levitation method for the detection of hookworm ova. Med J. 1921, 29:375-376.10.5694/j.1326-5377.1921.tb60654.xSearch in Google Scholar

16. Lei J, Leser M, Enan E: Nematicidal activity of two monoterpenoids and SER-2 tyramine receptor of Caenorhabditis elegans. Biochem Pharmacol. 2010, 79(7):1062-71.10.1016/j.bcp.2009.11.00219896925Search in Google Scholar

17. Abdel-Rahman FH, Alaniz NM, Saleh MA: Nematicidal activity of terpenoids. J Environ Sci Health B. 2013, 48(1):16-22.10.1080/03601234.2012.71668623030436Search in Google Scholar

18. Abongwa M, Buxton SK, Courtot E, Charvet CL, Neveu C, McCoy CJ, Verma S, Robertson AP, Martin RJ: Pharmacological profile of Ascaris suum ACR-16, a new homomeric nicotinic acetylcholine receptor widely distributed in Ascaris tissues. Br J Pharmacol. 2016, 173(16):2463-77.10.1111/bph.13524495995727238203Search in Google Scholar

19. Zenner L. Effective eradication of pinworms (Syphaciamuris, Syphacia obvelata and Aspiculuris tetraptera) from a rodent breeding colony by oral anthelmintic therapy. Lab Anim. 1998, 32(3):337-42.10.1258/0023677987805592029718483Search in Google Scholar

20. Pritchett KR, Johnston NA: A review of treatments for the eradication of pinworm infections from laboratory rodent colonies. Contemp Top Lab Anim Sci. 2002, 41(2):36-46.Search in Google Scholar

21. André WPP, Cavalcante GS, Ribeiro WLC, Santos JMLD, Macedo ITF, Paula HCB, Morais SM, Melo JV, Bevilaqua CML: Anthelmintic effect of thymol and thymol acetate on sheep gastrointestinal nematodes and their toxicity in mice. Rev Bras Parasitol Vet. 2017, 26(3): 323-330.10.1590/s1984-2961201705628977246Search in Google Scholar

22. Michiels J, Missotten J, Noe D, Fremaut D, Maene P, De Smet S: In vitro degradation and in vivo passage kinetics of carvacrol, thymol, eugenol and trans-cinnamaldehyde along the gastrointestinal tract of piglets. J Sci Food Agric. J Helminthol. 2008, 88:2371-2381.10.1002/jsfa.3358Search in Google Scholar

23. Ouwehand AC, Tiihonen K, Kettunen H, Peuranen P, Schulze H, Rautonen N. In vitro effects of essential oils on potential pathogens and beneficial members of the normal microbiota. Veterinarni Medicina. 2010, 55(2): 71-78.10.17221/152/2009-VETMEDSearch in Google Scholar

eISSN:
1820-7448
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Veterinary Medicine