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Low-grade chronic inflammation perpetuated by modern diet as a promoter of obesity and osteoporosis


1. Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O’Keefe JH, Brand-Miller J. Origins and evolution of the western diet: Health implications for the 21st century. Am J Clin Nutr 2005;81:341-54. PMID: 1569922010.1093/ajcn.81.2.34115699220Search in Google Scholar

2. Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 2008;233:674-88. doi: 10.3181/0711-MR-31110.3181/0711-MR-31118408140Search in Google Scholar

3. Simopoulos AP. Evolutionary aspects of diet, the omega-6/ omega-3 ratio and genetic variation: Nutritional implications for chronic diseases. Biomed Pharmacother 2006;60:502-7. PMID: 1704544910.1016/j.biopha.2006.07.08017045449Search in Google Scholar

4. Cordain L, Miller JB, Eaton SB, Mann N, Holt SH, Speth JD. Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets. Am J Clin Nutr 2000;71:682-92. PMID: 1070216010.1093/ajcn/71.3.68210702160Search in Google Scholar

5. Eaton SB, Konner M. Paleolithic nutrition. A consideration of its nature and current implications. N Engl J Med 1985;312:283-9. PMID: 298140910.1056/NEJM1985013131205052981409Search in Google Scholar

6. Eaton SB, Eaton SB 3rd, Sinclair AJ, Cordain L, Mann NJ. Dietary intake of long-chain polyunsaturated fatty acids during the paleolithic. World Rev Nutr Diet 1998;83:12-23. PMID: 964850110.1159/0000596729648501Search in Google Scholar

7. Rhodes DG, Clemens JC. Goldman JD. LaComb RP, Moshfegh AJ. 2009-2010 What We Eat In America, NHANES Tables 1-36 [displayed 6 June 2014]. Available at in Google Scholar

8. Ruiz-Nunez B, Pruimboom L, Dijck-Brouwer DA, Muskiet FA. Lifestyle and nutritional imbalances associated with western diseases: Causes and consequences of chronic systemic low-grade inflammation in an evolutionary context. J Nutr Biochem 2013;24:1183-201. doi: 10.1016/j. jnutbio.2013.02.009Search in Google Scholar

9. Cordain L, Eaton SB, Miller JB, Mann N, Hill K. The paradoxical nature of hunter-gatherer diets: Meat-based, yet non-atherogenic. Eur J Clin Nutr 2002;56(Suppl 1):S42-52. PMID: 1196552210.1038/sj.ejcn.160135311965522Search in Google Scholar

10. Whitaker JW. Feedlot Empire: Beef Cattle Feeding in Illinois and Iowa, 1840- 1900. Ames, Iowa: The Iowa State University Press; 1975.Search in Google Scholar

11. Kelly OJ, Gilman JC, Kim Y, Ilich JZ. Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. Nutr Res 2013;33:521-33. doi: 10.1016/j. nutres.2013.04.012Search in Google Scholar

12. De Lorgeril M, Salen P. Dietary prevention of coronary heart disease: The lyon diet heart study and after. World Rev Nutr Diet 2005;95:103-14. doi: 10.1159/00008827710.1159/00008827716151275Search in Google Scholar

13. Gropper S, Smith J. Advanced Nutrition and Human Metabolism. 6th ed. Belmont: Wadsworth Cengage Learning; 2013.Search in Google Scholar

14. De Gomez Dumm IN, Brenner RR. Oxidative desaturation of alpha-linoleic, linoleic, and stearic acids by human liver microsomes. Lipids 1975;10:315-7. PMID: 113421910.1007/BF025324511134219Search in Google Scholar

15. Nigam S, Fiore S, Luscinskas FW, Serhan CN. Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: Dissociation between lipid remodeling and adhesion. J Cell Physiol 1990;143:512-23. PMID:216285010.1002/jcp.10414303162162850Search in Google Scholar

16. Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio KB, Hong S, Arita M, Serhan CN. Resolvin E2: Identification and anti-inflammatory actions: Pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. Chem Biol 2006;13:1193-202. doi: 10.1016/j.chembiol.2006.09.01110.1016/j.chembiol.2006.09.01117114001Search in Google Scholar

17. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 2008;8:349-61. doi: 10.1038/nri229410.1038/nri2294274459318437155Search in Google Scholar

18. Ariel A, Serhan CN. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 2007;28:176-83. doi: 10.1016/ in Google Scholar

19. Ward P. Acute and chronic inflammation. In: Serhan CN, Ward PA, Gilory DW, editors. Fundamentals of inflammation. New York: Cambridge University Press; 2010. p. 1-16.10.1017/CBO9781139195737.002Search in Google Scholar

20. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444:860-7. PMID: 1716747410.1038/nature0548517167474Search in Google Scholar

21. Woods JA, Wilund KR, Martin SA, Kistler BM. Exercise, inflammation and aging. Aging Dis 2012;3:130-40. PMID: 22500274Search in Google Scholar

22. Endres S. Messengers and mediators: Interactions among lipids, eicosanoids, and cytokines. Am J Clin Nutr 1993;57(Suppl 5):798S-800S. PMID: 838643410.1093/ajcn/57.5.798S8386434Search in Google Scholar

23. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005;115:1111-9. PMID: 1586433810.1172/JCI25102108718515864338Search in Google Scholar

24. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001;286:327-34. doi: 10.1001/ jama.286.3.32710.1001/jama.286.3.32711466099Search in Google Scholar

25. Canavan B, Salem RO, Schurgin S, Koutkia P, Lipinska I, Laposata M, Grinspoon S. Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation. J Clin Endocrinol Metab 2005;90):5779-85. doi: 10.1210/ jc.2005-078010.1210/jc.2005-078016076944Search in Google Scholar

26. Van Dielen FM, van’t Veer C, Schols AM, Soeters PB, Buurman WA, Greve JW. Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord 2001;25:1759-66. doi: 10.1038/sj.ijo.080182510.1038/sj.ijo.080182511781755Search in Google Scholar

27. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y.Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 2000;102:1296-301. PMID: 1098254610.1161/01.CIR.102.11.1296Search in Google Scholar

28. Dodds RA, Merry K, Littlewood A, Gowen M. Expression of mRNA for IL1 beta, IL6 and TGF beta 1 in developing human bone and cartilage. J Histochem Cytochem 1994;42:733-44. PMID: 818903510.1177/42.6.81890358189035Search in Google Scholar

29. Teitelbaum SL. Postmenopausal osteoporosis, T cells, and immune dysfunction. Proc Natl Acad Sci USA 2004;101:16711-2. doi: 10.1073/pnas.040733510110.1073/pnas.040733510153474115557556Search in Google Scholar

30. Rosen CJ, Bouxsein ML. Mechanisms of disease: Is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2006;2:35-43. PMID:1693265010.1038/ncprheum007016932650Search in Google Scholar

31. Ilich JZ, Kelly OJ, Inglis JE, Panton LB, Duque G, Ormsbee MJ. Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels. Ageing Res Rev 2014;15C:51-60. doi: 10.1016/j. arr.2014.02.007Search in Google Scholar

32. Beyer I, Mets T, Bautmans I. Chronic low-grade inflammation and age-related sarcopenia. Curr Opin Clin Nutr Metab Care 2012;15:12-22. doi: 10.1097/MCO.0b013e32834dd29710.1097/MCO.0b013e32834dd29722108098Search in Google Scholar

33. Kim Y, Kelly OJ, Ilich JZ. Synergism of alpha-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth. Lipids 2013;48:787-802. doi: 10.1007/s11745-013-3803-510.1007/s11745-013-3803-523757205Search in Google Scholar

34. Kellinsalmi M, Parikka V, Risteli J, Hentunen T, Leskela HV, Lehtonen S, Selander K, Väänänen K, Lehenkari P. Inhibition of cyclooxygenase-2 down-regulates osteoclast and osteoblast differentiation and favours adipocyte formation in vitro. Eur J Pharmacol 2007;572:102-10. PMID: 1763209710.1016/j.ejphar.2007.06.03017632097Search in Google Scholar

35. Khosla S. Minireview: The OPG/RANKL/RANK system.Endocrinology 2001;142:5050-5. doi: 10.1210/ en.142.12.5050 10.1210/endo.142.12.853611713196Search in Google Scholar

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