1. bookVolume 70 (2016): Issue 5 (October 2016)
Journal Details
License
Format
Journal
eISSN
2255-890X
First Published
14 Sep 2008
Publication timeframe
6 times per year
Languages
English
access type Open Access

Evaluation of Histological Findings of Airways of Rats Exposed to Highly Polluted Indoor Air in Offices

Published Online: 30 Nov 2016
Volume & Issue: Volume 70 (2016) - Issue 5 (October 2016)
Page range: 341 - 344
Received: 21 Sep 2016
Journal Details
License
Format
Journal
eISSN
2255-890X
First Published
14 Sep 2008
Publication timeframe
6 times per year
Languages
English
Abstract

Humans are exposed to chemicals and PM (particulate matter), including ultrafine particles (nanoparticles), mainly through inhalation. This creates a risk to their health. Another effect to exposure is expression of cytokines and their role in lung inflammation and morphpathogenesis. We conducted a pilot project based on testing of realistic exposure scenarios by describing morphological changes of the respiratory tract in Wistar rats (male) during a 30-day exposure in office where there was high intensity of printing activities. Tracheal tissue of experimental animals had increasing concentrations of inflammatory interleukin IL-1 and decreasing concentrations of IL-6 and TNF-α. The lungs of the experimental animals tended to show focal infiltration of inflammatory cells, vascular plethora, focal and/or diffuse localisation of lymphatic nodules, and also vascular sclerosis and focal emphysema. The results suggested potential dangerous and adverse effect of poor indoor air quality (particles, including nanoparticles, and chemical compounds) on respiratory tract tissue of rats.

Keywords

Anonymous (2006). Approaches to safe nanotechnology: An information exchange with NIOSH. National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. Available at: http://www.cdc.gov/niosh/topics/nanotech/pdfs/Approaches_to_Safe_Nanotechnology.pdf (accessed 30 September 2016).Search in Google Scholar

Araujo, J. A., Barajas, B., Kleinman, M., Wang, X., Bennet, B. J., Gong, K. W., Navab, M., Harkema, J., Sioutas, C., Lusis, A. J., Nel, A. E. (2008). Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ. Res., 102, 589–596.10.1161/CIRCRESAHA.107.164970Search in Google Scholar

Barlow, P. G., Clouter, B. A., Donaldson, K., McCollum, J., Stone, V. (2005). Carbon black nanoparticles induce type II epithelial cells to release chemotoxins for alveolar macrophages. Particle Fibre Toxicol., 2 (1), 11.10.1186/1743-8977-2-11Search in Google Scholar

Chen, H. W., Su, S. F., Chien, C. T., Lin, W. H., Yu, S. L., Chou, C. C., Chen, J. W., Yang, P. C. (2006). Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. J. Feder. Amer. Soc. Exp. Biol., 20, E1732–E174110.1096/fj.06-6485fjeSearch in Google Scholar

Congrong, H. E., Morawska, L., Taplin, L. (2007). Particle emission characteristics of office printers. Environ. Sci. Technol., 41, 6039–6045.10.1021/es063049zSearch in Google Scholar

Donaldson, K., Aitken, R., Tran, L., Stone, V., Duffin, R., Forrest, G., Alexander, A. (2006). Carbon nanotubes: A review of their properties in relation to pulmonary toxicology and workplace safety. Tox. Sci., 92 (1), 5–22.10.1093/toxsci/kfj130Search in Google Scholar

Gilmour, P. S., Ziesenis, A., Morrison, E. R., Vickers, M. A., Drost, E. M., Ford, I., Karg, E., Mossa, C., Schroeppel, A., Ferron, G. A., Heyder, J., Greaves, M., MacNee, W., Donaldson, K. (2004). Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles. Toxicol. Appl. Pharmacol., 195, 35–44.10.1016/j.taap.2003.10.003Search in Google Scholar

Hsu, S. M., Raine, L., Fanger, H. (1981). The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Amer. J. Clin. Pathol., 75, 816–821.10.1093/ajcp/75.6.816Search in Google Scholar

Kipen, H. M., Laskin, D. L. (2005). Smaller is no always better: Nanotechnology yields nanotoxicology. Amer. J. Physiol.: Lung Cell. Mol. Physiol., 289, 296–297.Search in Google Scholar

Määttä, J., Luukkonen, R., Husgafvel-Pursiainen, K., Alenius, H., Savolainen, K. (2006). Comparison of hardwood and softwood dust-induced expression of cytokines and chemokines in mouse macrophage RAW 264.7 cells. Toxicology, 218 (1); 13–21.Search in Google Scholar

Mossman, B. T., Borm, P. J., Castranova, V., Cost, D. L., Donaldson, K., Kleeberger, R. (2007). Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular disease. Particle Fibre Toxicol., 4, 4.10.1186/1743-8977-4-4Search in Google Scholar

Negoescu, A., Guillermet, C., Lorimier, P., Brambilla, E., Labat-Moleur, F. (1998). Importance of DNA fragmentation in apoptosis with regard to TUNEL specificity. Biomed. Pharmacother., 52, 252–258.10.1016/S0753-3322(98)80010-3Search in Google Scholar

Nel, A., Xia, T., Maedler, L., Li, N. (2006). Toxic potentials of materials at the nanolevel. Science, 311, 622–627.10.1126/science.111439716456071Search in Google Scholar

Renwick, L. C., Brown, D., Clouter, A., Donaldson, K. (2004). Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup. Environ. Med., 61, 442–447.10.1136/oem.2003.008227174079215090666Search in Google Scholar

Rothen-Rutishauser, B., Mühlfeld, C., Blank, F., Musso, C., Gehr, P. (2007). Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. Particle Fibre Toxicol., 4, 9.10.1186/1743-8977-4-9203973017894871Search in Google Scholar

Shah, A. P., Pietropaoli, A. P., Frasier, L. M., Speer, D. M., Chalupa, D. C., Delehanty, J. M., Huang, L. S., Utell, M. J., Frampton, M. W. (2008). Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects. Environ. Health Perspect., 116 (3), 375–380.10.1289/ehp.10323226506018335106Search in Google Scholar

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