1. bookVolume 70 (2016): Issue 4 (August 2016)
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Journal
eISSN
2255-890X
First Published
14 Sep 2008
Publication timeframe
6 times per year
Languages
English
access type Open Access

Risk Factors that Determine Less Favourable Hospitalisation Course and Outcome in Patients with ESBL Producing Enterobacteriaceae Infection: Preliminary Results / Riska Faktori, Kas Nosaka Sliktāku Hospitalizācijas Gaitu Un Iznākumu Pacientiem Ar Esbl Producējošu Enterobacteriaceae Dzimtas Baktēriju Infekciju: Sākotnējie Rezultāti

Published Online: 04 Aug 2016
Volume & Issue: Volume 70 (2016) - Issue 4 (August 2016)
Page range: 252 - 255
Received: 12 May 2016
Journal Details
License
Format
Journal
eISSN
2255-890X
First Published
14 Sep 2008
Publication timeframe
6 times per year
Languages
English
Abstract

Hospitalisation course and outcome for patients with extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae infection is less favourable due to extensive antibacterial resistance. This study was conducted to identify possible risk factors that could influence the hospitalisation course and outcome in these patients. The study protocol included demographic, clinical, hospitalisation, bacteriological and plasmid genetic data. The preliminary study results showed that hospitalisation course and outcome was less favourable for internal medicine profile patients with ESBL producing bacteria, TEM gene presence in the bacterial plasmid genome, patient age < 65 years and patients with infectious and musculoskeletal diseases. The study includes preliminary data only and further studies should be carried out to verify the suggested risk factors.

Keywords

Abdalla, A. A. R. K., Mohamed, A. M. A. (2014). Prevalence of extended spectrum β-lactamase producing Klebsiella pneumonia in clinical isolates. Jundishapur J. Microbiol., 7, 1-5.Search in Google Scholar

Anonymous (2013). EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and/or epidemiological importance. Available at: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Resistance_mechanisms/EUCAST_detection_of_resistance_mechanisms_v1.0_20131211.pdf (acessed 19.06.2016).Search in Google Scholar

Anonymous (2015). WHO. International statistical classification of diseases and related health problems. ICD-10 Version. Available at: http://apps.who.int/classifications/icd10/browse/2015/en (accessed 19.06.2016).Search in Google Scholar

Concepts, C., Peleg, A. Y., Hooper, D. C. (2010). Hospital-acquired infections due to gram-negative bacteria. New Engl. J. Med., 362, 1804-1813.10.1056/NEJMra0904124310749920463340Search in Google Scholar

Du, B., An, Y., Kang, Y., Yu, X., Zhao, M., Ma, X., Ai, Y., Xu, Y., Wang, Y., Qian, C., Wu, D., Sun, R., Li, S., Hu, Z., Cao, X., Zhou, F., Jiang, L., Lin, J., Chen, E., Qin, T., He, Z., Zhou, L. (2013). Characteristics of critically ill patients in ICUs in mainland China. Crit. Care Med., 41, 84-92.10.1097/CCM.0b013e31826a408223222268Search in Google Scholar

Edelstein, M., Pimkin, M., Palagin, I., Edelstein, I., Stratchounski, L. (2003). Prevalence and molecular epidemiology of CTX-M extended-spectrumlactamase- producing Escherichia coli and Klebsiella pneumoniae in Russian hospitals. Antimicrob. Agents. Chemother., 47, 3724-3732.10.1128/AAC.47.12.3724-3732.200329619014638473Search in Google Scholar

Kim, B. N., Woo, J. H., Kim, M. N., Ryu, J., Kim, Y. S. (2002). Clinical implications of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae bacteraemia. J. Hosp. Infect., 52, 99-106.10.1053/jhin.2002.128812392901Search in Google Scholar

Mayr, V. D., Dünser, M. W., Greil, V., Jochberger, S., Luckner, G., Ulmer, H., Friesenecker, B. E., Takala, J., Hasibeder, W. R. (2006). Causes of death and determinants of outcome in critically ill patients. Crit. Care, 10 (6), R154.Search in Google Scholar

Mehrgan, H., Rahbar, M., Arab-halvaii, Z. (2010). High prevalence of extended- spectrum beta-lactamase-producing Klebsiella pneumoniae in a tertiary care hospital in Tehran. Iran J. Infect. Dev. Ctries., 4 (3), 132-138.Search in Google Scholar

Nüesch-Inderbinen, M. T., Hächler, H., Kayser, F. H. (1996). Detection of genes coding for extended-spectrum SHV beta-lactamases in clinical isolates by a molecular genetic method, and comparison with the E test. Eur. J. Clin. Microbiol. Infect. Dis., 15, 398-402.10.1007/BF016900978793399Search in Google Scholar

Peralta, G., Lamelo, M., Alvarez-García, P., Velasco, M., Delgado, A., Horcajada, J. P., Montero, M., Pia Roiz, M., Farinas, M. C., Alonso, J., Martinez, L. M., Gutierrez-Macias, A., Alava, J. A., Rodríguez, A., Fleites, A., Navarro, V., Sirvent, E., Capdevila, J. A. (2012). Impact of empirical treatment in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. bacteremia. A multicentric cohort study. BMC Infect. Dis., 12, 245-251.10.1186/1471-2334-12-245351970123038999Search in Google Scholar

Shaikh, S., Fatima, J., Shakil, S., Rizvi, S. M. D., Kamal, M. A. (2015). Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment. Saudi J. Biol. Sci., 22, 90-101.10.1016/j.sjbs.2014.08.002428162225561890Search in Google Scholar

Skippen, I., Shemko, M., Turton, J., Kaufmann, M. E., Palmer, C., Shetty, N. (2006). Epidemiology of infections caused by extended-spectrum _-lactamase-producing Escherichia coli and Klebsiella spp.: A nested case-control study from a tertiary hospital in London. J. Hosp. Infect., 64, 115-23.10.1016/j.jhin.2006.05.01016859810Search in Google Scholar

Spanu, T., Luzzaro, F., Perilli, M., Amicosante, G., Toniolo, A., Fadda, G. (2002). Occurrence of extended-spectrum beta-lactamases in members of the family Enterobacteriaceae in Italy: Implications for resistance to beta-lactams and other antimicrobial drugs. Antimicrob. Agents Chemother., 46, 196-202.10.1128/AAC.46.1.196-202.200212698311751134Search in Google Scholar

Thu Trang, N. H., Thieu Nga, T. V., Campbell, J. I., Hiep, N. T., Farrar, J., Baker, S., Duy, P. T. (2013). The characterization of ESBL genes in Escherichia coli and Klebsiella pneumoniae causing nosocomial infections in Vietnam. J. Infect. Dev. Ctries., 7, 922-928.10.3855/jidc.293824334938Search in Google Scholar

Wu, T. L., Siu, L. K., Su, L. H., Lauderdale, T. L., Lin, F. M., Leu, H. S., Lin, T. Y., Ho, M. (2001). Outer membrane protein change combined with co-existing TEM-1 and SHV-1 beta-lactamases lead to false identification of ESBL-producing Klebsiella pneumoniae. J. Antimicrob. Chemother., 47, 755-761.10.1093/jac/47.6.75511389107Search in Google Scholar

Wu, Y. H., Chen, P. L., Hung, Y. P., Ko, W. C. (2014). Risk factors and clinical impact of levofloxacin or cefazolin nonsusceptibility or ESBL production among uropathogens in adults with community-onset urinary tract infections. J. Microbiol. Immunol. Infect., 47, 197-203.10.1016/j.jmii.2012.09.00123063776Search in Google Scholar

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