1. bookVolume 31 (2018): Issue 3 (September 2018)
Journal Details
License
Format
Journal
eISSN
2300-6676
ISSN
2084-980X
First Published
30 May 2014
Publication timeframe
4 times per year
Languages
English
access type Open Access

Lepidium meyenii (Maca) – multidirectional health effects – review

Published Online: 29 Oct 2018
Page range: 107 - 112
Received: 09 Nov 2017
Accepted: 19 Apr 2018
Journal Details
License
Format
Journal
eISSN
2300-6676
ISSN
2084-980X
First Published
30 May 2014
Publication timeframe
4 times per year
Languages
English
Abstract

Lepidium meyenii, commonly known as Maca, is a Peruvian plant that grows high in the Andes, in areas over 4,000 meters above sea level. Its composition contains almost all of the essential amino acids and twenty of the essential fatty acids needed by man, as well as many vitamins, minerals and several sterols and glucosinolates. The specific and unique unsaturated acids and amides found only in this plant are the macaenes and macamides. Most valuable ingredients are contained within the hypocotyls. Maca comes in three forms, based on its root colour, yellow, red and black. Although used individually, consumption recommendations are usually for a mix of all three. Since Inca times, it has been considered as super food.

Although now mostly used in the form of a supplement, ongoing research does not exclude future applications of Maca as medicine. It is attributed to have an effect on male fertility (adding energy and vitality), and in regulating hormone secretion. In animal studies, Maca has been shown to have antioxidant, neuroprotective effects and antiviral activity. Moreover, it has been demonstrated to alleviate the effects of depression. In addition, there are reports that Maca reduces the development of cancer and osteoporosis, improves memory, facilitates concentration and alleviates the symptoms of menopause. The obtained results, however, require further analysis to confirm its effect. Currently, there is little information on toxicity, so there is a need for specialized research in this area, and on-going research concerns the most effective variety and form of preparation of Maca for administration to achieve best effects. The potential of Maca as medicine exists. The increasing pan-continental popularity of Maca has created the need for a better understanding of its action mechanisms.

Keywords

1. Meissner HO, Mscisz A, Kedzia B, Pisulewski P, Piatkowska E. Peruvian maca: Two scientific names Lepidium Meyenii walpers and Lepidium Peruvianum chacon – Are they phytochemically-synonymous? Int J Biomed Sci. 2015;11(1):1-15.Search in Google Scholar

2. Dini A, Migliuolo G, Rastrelli L, Saturnino P, Schettino O. Chemical composition of Lepidium meyenii. Food Chem. 1994;49(4):347-9.10.1016/0308-8146(94)90003-5Search in Google Scholar

3. Cui B, Zheng BL, He K, Zheng QY. Imidazole alkaloids from Lepidium meyenii. J Nat Prod. 2003;66(8):1101-3.10.1021/np030031i12932133Search in Google Scholar

4. Ganzera M, Zhao J, Muhammad I, Khan IA. Chemical profiling and standardization of Lepidium meyenii (Maca) by reversed phase high performance liquid chromatography. Chem Pharm Bull (Tokyo). 2002;50(7):988-91.10.1248/cpb.50.98812130863Search in Google Scholar

5. Li G, Ammermann U, Quirós CF. Glucosinolate contents in maca (Lepidium peruvianum Chacón) seeds, sprouts, mature plants and several derived commercial products. Econ Bot. 2001;55(2):255-62.10.1007/BF02864563Search in Google Scholar

6. Gerbarg PL, Brown RP. Phytomedicines for prevention and treatment of mental health disorders. Psychiatr Clin North Am. 2013;36:37-47.10.1016/j.psc.2012.12.00423538075Search in Google Scholar

7. Gonzales GF, Villaorduña L, Gasco M, Rubio J, Gonzales C. Maca (Lepidium meyenii walp), a review of its biological properties. Rev Peru Med Exp Salud Publica. 2014;31(1):100-10.10.17843/rpmesp.2014.311.15Search in Google Scholar

8. Gonzales-Castañeda C, Gonzales GF. Hypocotyls of Lepidium meyenii (maca), a plant of the Peruvian highlands, prevent ultraviolet A-, B-, and C-induced skin damage in rats. Photodermatol Photoimmunol Photomed. 2008;24(1):24-31.10.1111/j.1600-0781.2008.00330.x18201354Search in Google Scholar

9. Gonzales C, Rubio J, Gasco M, Nieto J, Yucra S, Gonzales GF. Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (MACA) on spermatogenesis in rats. J Ethnopharmacol. 2006;103(3):448-54.10.1016/j.jep.2005.08.03516174556Search in Google Scholar

10. Gasco M, Aguilar J, Gonzales GF. Effect of chronic treatment with three varieties of Lepidium meyenii (Maca) on reproductive parameters and DNA quantification in adult male rats. Andrologia. 2007;39(4):151-8.10.1111/j.1439-0272.2007.00783.x17683465Search in Google Scholar

11. Gonzalez GF, Córdova A, Vega K, Chung A, Villena A, Góñez C. Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing propeties, on serum reproductive hormone levels in adult healthy men. J Endocrinol. 2003;176(1):163-8.10.1677/joe.0.176016312525260Search in Google Scholar

12. Ohta Y, Kawate N, Inaba T, Morii H, Takahashi K, Tamada H. Feeding hydroalcoholic extract powder of Lepidium meyenii (maca) enhances testicular gene expression of 3β-hydroxysteroid dehydrogenase in rats. Andrologia. 2017;49(10):e12792.10.1111/and.12792Search in Google Scholar

13. Ohta Y, Yoshida K, Kamiya S, Kawate N, Takahashi M, Inaba T, et al. Feeding hydroalcoholic extract powder of Lepidium meyenii (maca) increases serum testosterone concentration and enhances steroidogenic ability of Leydig cells in male rats. Andrologia. 2016;48(3):347-54.10.1111/and.12453Search in Google Scholar

14. Yoshida K, Ohta Y, Kawate N, Takahashi M, Inaba T, Hatoya S, et al. Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. Andrologia. 2018;50(1):1-6.10.1111/and.12803Search in Google Scholar

15. Meissner HO, Kapczynski W, Mscisz A, Lutomski J. Use of gelatinized maca (Lepidium peruvianum) in early postmenopausal women. Int J Biomed Sci [Internet]. 2005;1(1):33-45.Search in Google Scholar

16. Rubio J, Dang H, Gong M, Liu X, Chen S lin, Gonzales GF. Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice. Food Chem Toxicol. 2007;45(10):1882-90.10.1016/j.fct.2007.04.002Search in Google Scholar

17. Liu X, Rubio J, Qiong W, Jiang Z, Dang H, Chen SL, et al. Aqueous extract of black maca (Lepidium meyenii) on memory impairment induced by ovariectomy in mice. Evid Based Complement Alternat Med. 2011;2011:253958.Search in Google Scholar

18. Pino-Figueroa A, Nguyen D, Maher TJ. Neuroprotective effects of Lepidium meyenii (Maca): Annals of the New York Academy of Sciences. Ann N Y Acad Sci. 2010;1199:77-85.10.1111/j.1749-6632.2009.05174.xSearch in Google Scholar

19. Guo SS, Gao XF, Gu YR, Wan ZX, Lu AM, Qin ZH, et al. Preservation of cognitive function by Lepidium meyenii (Maca) is associated with improvement of mitochondrial activity and upregulation of autophagy-related proteins in middle-aged Mouse Cortex. Evid Based Complement Alternat Med. 2016(2):1-9.10.1155/2016/4394261Search in Google Scholar

20. Rodríguez-Huamán Á, Casimiro-Gonzales S, Chávez-Pérez JA, Gonzales-Arimborgo C, Cisneros-Fernández R, Aguilar-Mendoza LÁ, et al. Antioxidant and neuroprotector effect of Lepidium meyenii (maca) methanol leaf extract against 6-hydroxy dopamine (6-OHDA)-induced toxicity in PC12 cells. Toxicol Mech Methods. 2017;27(4):279-85.10.1080/15376516.2016.1275908Search in Google Scholar

21. Masoudi N, Ibanez-Cruceyra P, Offenburger SL, Holmes A, Gartner A. Tetraspanin (TSP-17) Protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans. PLoS Genet. 2014;10(12):1-15.Search in Google Scholar

22. del Valle Mendoza J, Pumarola T, Gonzales LA, del Valle LJ. Antiviral activity of maca (Lepidium meyenii) against human influenza virus. Asian Pac J Trop Med. 2014;7(1):415-20.10.1016/S1995-7645(14)60268-6Search in Google Scholar

23. Qiu C, Zhu T, Lan L, Zeng Q, Du Z. Analysis of maceaene and macamide contents of petroleum ether extract of black, yellow, and purple Lepidium meyenii (Maca) and their antioxidant effect on diabetes mellitus rat model. Brazilian Arch Biol Technol. 2016;59:1-9.10.1590/1678-4324-2016150462Search in Google Scholar

24. Večeřa R, Orolin J, Škottová N, Kazdová L, Oliyarnik O, Ulrichová J, et al. The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat. Plant Foods Hum Nutr. 2007;62(2):59-63.10.1007/s11130-007-0042-z17333395Search in Google Scholar

25. Choi EH, Kang J Il, Cho JY, Lee SH, Kim TS, Yeo IH, et al. Supplementation of standardized lipid-soluble extract from maca (Lepidium meyenii) increases swimming endurance capacity in rats. J Funct Foods. 2012;4(2):568-73.10.1016/j.jff.2012.03.002Search in Google Scholar

26. Wang W, Zou Y, Li Q, Mao R, Shao X, Jin D, et a l. Immunomodulatory effects of a polysaccharide purified from Lepidium meyenii Walp. on macrophages. Process Biochem. 2016;51(4):542-53.10.1016/j.procbio.2016.01.003Search in Google Scholar

27. Li J, Sun Q, Meng Q, Wang L, Xiong W, Zhang L. Anti-fatigue activity of polysaccharide fractions from Lepidium meyenii Walp. (Maca). Int J Biol Macromol. 2017;95:1305-11.10.1016/j.ijbiomac.2016.11.03127840217Search in Google Scholar

28. Zhang M, Wu W, Ren Y, Li X, Tang Y, Min T, et al. Structural characterization of a novel polysaccharide from Lepidium meyenii (Maca) and analysis of its regulatory function in macrophage polarization in vitro. J Agric Food Chem. 2017;65(6):1146-57.10.1021/acs.jafc.6b0521828117590Search in Google Scholar

29. Ai Z, Cheng A-F, Yu Y-T, Yu L-J, Jin W. Antidepressant-like behavioral, anatomical, and biochemical effects of petroleum ether extract from Maca (Lepidium meyenii) in mice exposed to chronic unpredictable mild stress. J Med Food [Internet]. 2014;17(5):535-42.10.1089/jmf.2013.2950402560824730393Search in Google Scholar

30. Gonzales GF. Ethnobiology and ethnopharmacology of Lepidium meyenii (Maca), a plant from the peruvian highlands. Evid Based Complement Alternat Med. 2012;2012:193496.10.1155/2012/193496318442021977053Search in Google Scholar

31. Lin L, Huang J, Sun-Waterhouse D, Zhao M, Zhao K, Que J. Maca (Lepidium meyenii) as a source of macamides and polysaccharide in combating of oxidative stress and damage in human erythrocytes. Int J Food Sci Technol. 2018;53(2):304-12.10.1111/ijfs.13586Search in Google Scholar

32. Beharry S, Heinrich M. Is the hype around the reproductive health claims of maca (Lepidium meyenii Walp.) justified? J Ethnopharmacol. 2018;211:126-70.10.1016/j.jep.2017.08.00328811221Search in Google Scholar

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