1. bookVolume 31 (2018): Issue 2 (June 2018)
Journal Details
License
Format
Journal
eISSN
2300-6676
ISSN
2084-980X
First Published
30 May 2014
Publication timeframe
4 times per year
Languages
English
access type Open Access

Synthesis and Characterization of Molecularly Imprinted Polymer for Tramadol Hcl Using Acryl Amide and 2-Hydroxyethyl Meth Acrylate as Monomers

Published Online: 28 Jul 2018
Volume & Issue: Volume 31 (2018) - Issue 2 (June 2018)
Page range: 81 - 88
Received: 18 Dec 2017
Accepted: 15 Feb 2018
Journal Details
License
Format
Journal
eISSN
2300-6676
ISSN
2084-980X
First Published
30 May 2014
Publication timeframe
4 times per year
Languages
English
Abstract

Four electrodes were synthesized based on molecularly imprinted polymers (MIPs). Two MIPs were prepared by using tramadol hydrochloride (TRH) as the template, acryl amide (AA) and 2-hydroxy ethyl meth acrylate (2-HEMA) as monomers, divinyl benzene as a cross linker, and benzoyl peroxide as initiator, respectively. The same composition was used to prepare non-imprinted polymers (NIPs), but without the template (Tramadol hydrochloride). Different plasticizers were employed to prepare the membranes; tris (ethyl hexyl) phosphate (TEHP), tri Butyl phosphate (TBP), di-octyl phthalate (DOP) and nitrobenzene (NB) in PVC matrix. The electrode characteristics and properties were studied, including: slope, detection limit, life time and linearity range. The results of selectivity coefficient measurements using amino acids as interfering species showed no effect on tramadol electrode response. The prepared electrodes were intended for use in determining tramadol in pharmaceutical samples

Keywords

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