<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In the process of anterior pituitary gland development and maturation, numerous transcription factors were involved in the pituitary organogenesis. To date, the lack of knowledge on POU1F1-PROP1-PITX1-SIX3 pathway genes affecting growth traits was reported in Chinese goat breeds. The objective of this work was to identify genetic variants of the POU1F1, PROP1, PITX1 and SIX3 genes, as well as to evaluate their associations with growth traits in goats. The results showed that one novel and five reported single nucleotide polymorphisms (SNP) were confirmed in above four genes. The novel SNP (NC_019460.2:g.1100T>A) was located in intron 1 of SIX3 gene. Among these loci, DQ826397.1:g.102T>G (SNP1), DQ826397.1:g.279T>C (SNP2) and NC_019460.2:g.1100T>A (SNP6) were associated with growth traits. In details, the SNP1 locus had significant association with hucklebone width (P&lt;0.05) and hucklebone width index (P&lt;0.05) in the Guanzhong dairy goat. The SNP2 locus was associated with body weight (P&lt;0.05), chest circumference (P&lt;0.01), chest width (P&lt;0.05), hucklebone width (P&lt;0.05), cannon circumference (P&lt;0.01) and trunk index (P&lt;0.01) in the Hainan black goat. The SNP6 locus was significantly associated with hucklebone width index (P&lt;0.05) and chest width (P&lt;0.05) in the Guanzhong dairy goat and Hainan black goat, respectively. These findings indicated that goat POU1F1-PROP1-PITX1-SIX3 pathway genes were important genetic factors, which could affect growth traits. Three SNPs detected in this study may be useful for potential marker-assisted selection programs in goat breeding and production.</p></abstract>

In the process of anterior pituitary gland development and maturation, numerous transcription factors were involved in the pituitary organogenesis. To date, the lack of knowledge on POU1F1-PROP1-PITX1-SIX3 pathway genes affecting growth traits was reported in Chinese goat breeds. The objective of this work was to identify genetic variants of the POU1F1, PROP1, PITX1 and SIX3 genes, as well as to evaluate their associations with growth traits in goats. The results showed that one novel and five reported single nucleotide polymorphisms (SNP) were confirmed in above four genes. The novel SNP (NC_019460.2:g.1100T>A) was located in intron 1 of SIX3 gene. Among these loci, DQ826397.1:g.102T>G (SNP1), DQ826397.1:g.279T>C (SNP2) and NC_019460.2:g.1100T>A (SNP6) were associated with growth traits. In details, the SNP1 locus had significant association with hucklebone width (P<0.05) and hucklebone width index (P<0.05) in the Guanzhong dairy goat. The SNP2 locus was associated with body weight (P<0.05), chest circumference (P<0.01), chest width (P<0.05), hucklebone width (P<0.05), cannon circumference (P<0.01) and trunk index (P<0.01) in the Hainan black goat. The SNP6 locus was significantly associated with hucklebone width index (P<0.05) and chest width (P<0.05) in the Guanzhong dairy goat and Hainan black goat, respectively. These findings indicated that goat POU1F1-PROP1-PITX1-SIX3 pathway genes were important genetic factors, which could affect growth traits. Three SNPs detected in this study may be useful for potential marker-assisted selection programs in goat breeding and production.

Associations of six SNPs of POU1F1-PROP1-PITX1-SIX3 pathway genes with growth traits in two Chinese indigenous goat breeds

College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi, 712100,

Department of Pharmaceutical Science and Technology/Animal Science, Heze University, Heze, Shandong, 274015,

Annals of Animal Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

In the process of anterior pituitary gland development and maturation, numerous transcription factors were involved in the pituitary organogenesis. To date,...

Associations of six SNPs of POU1F1-PROP1-PITX1-SIX3 pathway genes with growth traits in two Chinese indigenous goat breeds

Article Category: Animal genetics and breeding

Published Online: Apr 28, 2017

Page range: 399 - 411

Received: Feb 07, 2016

Accepted: Oct 11, 2016

DOI: https://doi.org/10.1515/aoas-2016-0066

Keywords
goat, POU1F1 gene, PROP1 gene, PITX1 gene, SIX3 gene, polymorphism, growth traits

© by Hong Chen

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Associations of six SNPs of POU1F1-PROP1-PITX1-SIX3 pathway genes with growth traits in two Chinese indigenous goat breeds

Article Category: Animal genetics and breeding

Published Online: Apr 28, 2017

Page range: 399 - 411

Received: Feb 07, 2016

Accepted: Oct 11, 2016

DOI: https://doi.org/10.1515/aoas-2016-0066

Keywordsgoat, POU1F1 gene, PROP1 gene, PITX1 gene, SIX3 gene, polymorphism, growth traits

© by Hong Chen

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
goat, POU1F1 gene, PROP1 gene, PITX1 gene, SIX3 gene, polymorphism, growth traits