<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Copper (Cu) is required for all basic biochemical and physiological processes. The aim of this study was to evaluate the effects of different sources of dietary Cu on the histomorphometry of liver and jejunal epithelium in adult rats. Male 12-week-old rats were used in a 12-week experiment. The control diet provided the required Cu level from sulfate, and other two diets were supplemented with Cu as a glycine complex at 75% and 100% of daily requirement. Basal hematological and plasma biochemical analyses were also performed. There was no effect of Cu supplementation on the liver weight and the plasma and liver Cu concentration. Histomorphometric analysis of liver tissue showed an increase in the collagen amount and intracellular space in the group supplemented with Cu amino acid. Cu given in the organic form at 100% of daily requirement decreased the muscular and submucosa layer and the crypt depth. In turn, organic copper given at 75% of daily requirement did not influence the intestinal morphology. Dietary Cu given to adult rats as copper sulfate or a glycine complex meeting 100% of the daily requirement appears to be less harmful with regard to intestinal epithelium than when given as a glycine complex at 100% of daily requirement.</p></abstract>

Copper (Cu) is required for all basic biochemical and physiological processes. The aim of this study was to evaluate the effects of different sources of dietary Cu on the histomorphometry of liver and jejunal epithelium in adult rats. Male 12-week-old rats were used in a 12-week experiment. The control diet provided the required Cu level from sulfate, and other two diets were supplemented with Cu as a glycine complex at 75% and 100% of daily requirement. Basal hematological and plasma biochemical analyses were also performed. There was no effect of Cu supplementation on the liver weight and the plasma and liver Cu concentration. Histomorphometric analysis of liver tissue showed an increase in the collagen amount and intracellular space in the group supplemented with Cu amino acid. Cu given in the organic form at 100% of daily requirement decreased the muscular and submucosa layer and the crypt depth. In turn, organic copper given at 75% of daily requirement did not influence the intestinal morphology. Dietary Cu given to adult rats as copper sulfate or a glycine complex meeting 100% of the daily requirement appears to be less harmful with regard to intestinal epithelium than when given as a glycine complex at 100% of daily requirement.

Alterations in intestinal and liver histomorphology and basal hematological and biochemical parameters in relation to different sources of dietary copper in adult rats

Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-950 Lublin,

Department of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin,

Institute of Animal Nutrition and Bromatology, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin,

Annals of Animal Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Copper (Cu) is required for all basic biochemical and physiological processes. The aim of this study was to evaluate the effects of different sources of...

Alterations in intestinal and liver histomorphology and basal hematological and biochemical parameters in relation to different sources of dietary copper in adult rats

Article Category: Animal nutrition, and feedstuffs

Published Online: Apr 28, 2017

Page range: 477 - 490

Received: Apr 26, 2016

Accepted: Aug 18, 2016

DOI: https://doi.org/10.1515/aoas-2016-0056

Keywords
copper, Cu-Gly, liver histomorphometry, jejunum, biochemical parameter, adult rat

© by Ewa Tomaszewska

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Alterations in intestinal and liver histomorphology and basal hematological and biochemical parameters in relation to different sources of dietary copper in adult rats

Article Category: Animal nutrition, and feedstuffs

Published Online: Apr 28, 2017

Page range: 477 - 490

Received: Apr 26, 2016

Accepted: Aug 18, 2016

DOI: https://doi.org/10.1515/aoas-2016-0056

Keywordscopper, Cu-Gly, liver histomorphometry, jejunum, biochemical parameter, adult rat

© by Ewa Tomaszewska

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
copper, Cu-Gly, liver histomorphometry, jejunum, biochemical parameter, adult rat