<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylpyrollidone (2.5 %), croscarmellose sodium (2 %) and mannitol (50 %); it was then lyophilized into ODT in a mass ratio of 1:2, respectively. ODTs containing QT SLMPs showed: average wetting time (40.92 s), average oral disintegration time (21.49 s), average hardness (16.85 N) and also imparted suitable viscosity to suspend pellets during the lyophilization process. In conclusion, lyophilization is a promising technique for the formulation of multiparticulate systems into ODTs.</p></abstract>

Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylpyrollidone (2.5 %), croscarmellose sodium (2 %) and mannitol (50 %); it was then lyophilized into ODT in a mass ratio of 1:2, respectively. ODTs containing QT SLMPs showed: average wetting time (40.92 s), average oral disintegration time (21.49 s), average hardness (16.85 N) and also imparted suitable viscosity to suspend pellets during the lyophilization process. In conclusion, lyophilization is a promising technique for the formulation of multiparticulate systems into ODTs.

A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets

Pharmaceutics Department, Faculty of Pharmacy, Alexandria University, Alexandria,

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form...

A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets

Published Online: Oct 15, 2016

Page range: 515 - 532

Accepted: Feb 21, 2016

DOI: https://doi.org/10.1515/acph-2016-0041

Keywords
solid lipid micro pellets, multiparticulate, quetiapine, orally disintegrating tablets

© by Ahmed Refaat

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets

Published Online: Oct 15, 2016

Page range: 515 - 532

Accepted: Feb 21, 2016

DOI: https://doi.org/10.1515/acph-2016-0041

Keywordssolid lipid micro pellets, multiparticulate, quetiapine, orally disintegrating tablets

© by Ahmed Refaat

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
solid lipid micro pellets, multiparticulate, quetiapine, orally disintegrating tablets