Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology

1. M. V. Srikanth, S. A. Sunil, N. S. Rao, B. J. Ram and K. V. R. Murthy, Statistical design and evaluation of a propranolol HCl gastric floating tablet, Acta Pharm. Sinica B.2 (2012) 60–69; DOI: http://dx.doi.org/10.1016/j.apsb.2011.12.008.Search in Google Scholar

2. A. Nanda, M. Ola, R. Bhaskar, C. K. Sharma and S. Nayak, Formulation and evaluation of an effervescent, gastroretentive drug delivery system, Pharm. Tech. 10 (2010) 60–71; DOI: 10.4103/0253-7613.77344.10.4103/0253-7613.77344Search in Google Scholar

3. S. Arora, J. Ali, A. Ahuja, R. K. Khar and S. Baboota, Floating drug delivery systems: a review. AAPS PharmSciTech. 6 (2005) E372-90; DOI: 10.1208/pt060347.10.1208/pt060347Search in Google Scholar

4. V. S. Meka, B. J. Ram, S. A. Sunil, N. S. Rao and K. Ramanamurthy, Gastroretentive drug delivery systems: Novel approaches and its evaluation – a review, Int. J. Pharm. Rev. Res.10 (2011) 203–216.Search in Google Scholar

5. V. S. Meka, H. W. L. Vanitha, S. R. Dharmalingham, R. Sheshala and A. Gorajana, Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate, Acta Pharm. 64 (2014) 485–494. DOI: 10.2478/acph-2014-0038.10.2478/acph-2014-0038Search in Google Scholar

6. B. N. Singh and K. H. Kim, Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention, J. Control. Release63 (2000) 235–259; DOI: 10.1016/S0168-3659(99)00204-7.10.1016/S0168-3659(99)00204-7Search in Google Scholar

7. A. Chandel, K. Chauhan, B. Parashar, H. Kumar and S. Arora, Floating drug delivery systems: a better approach, Int. Current. Pharm. J. 1 (2012) 110–118; DOI: http://dx.doi.org/10.3329/icpj.v1i5.10283.Search in Google Scholar

8. S. Desai and S. Bolton, A floating controlled release drug delivery system: in vitro-in vivo evaluation, Pharm. Res. 10 (1993) 1321–1325; DOI: 10.1023/A:1018921830385.10.1023/A:1018921830385Search in Google Scholar

9. J. Dubeh and N. Verma, Floating Drug Delivery System: A Review, Int. J. Pharm. Sci. Res.4 (2013) 2893–2899; DOI: 10.13040/IJPSR.0975-8232.4(8).2893-99.10.13040/IJPSR.0975-8232.4(8).2893-99Search in Google Scholar

10. P. J. Barnes, Theophylline, Am. J. Respir. Crit. Care Med. 188 (2013) 901–906; DOI: 10.1164/rccm.201302-0388PP.10.1164/rccm.201302-0388PP23672674Search in Google Scholar

11. Theophylline, http://www.drugs.com/pro/theophylline.html; access date 15/10/2014.Search in Google Scholar

12. V. S. Meka and V. R. M. Kolapalli, Formulation of gastroretentive floating drug delivery system using hydrophilic polymers and its in vitro characterization, Braz. J. Pharm. Sci. 50 (2014) 431–439; DOI: http://dx.doi.org/10.1590/S1984-82502014000200023.Search in Google Scholar

13. V. S. Meka, S. Pillai, S. R. Dharmalingham, R. Sheshala and A. Gorajana, Preparation and in vitro characterization of a non-effervescent floating drug delivery system for poorly soluble drug, glipizide, Acta Pol. Pharm. Drug Res.72 (2015) 193–204.Search in Google Scholar

14. Evonik Industries. EUDRAGIT^® L100, http://eudragit.evonik.com/product/eudragit/en/prod-uctsservices/eudragit-products/enteric-formulations/l-100/pages/default.aspx; access date 24/11/2015.Search in Google Scholar

15. A. Becker, F. Katzen and L. Lelpi, Xanthan gum biosynthesis and application: a biochemical/genetic perspective, Appl. Microbiol. Biotechnol. 50 (1998) 145–152; DOI: 10.1007/s002530051269.10.1007/s002530051269Search in Google Scholar

16. S. Kumar, R. K. Sahu, S. Sharma and R. Jangde, Design and evaluation of an oral floating matrix tablet of salbutamol sulphate, Trop. J. Pharm. Res. 11 (2012) 569–576; DOI: http://dx.doi.org/10.4314/tjpr.v11i4.7.Search in Google Scholar

17. B. Y. Choia, H. J. Park, S. J. Hwangb and J. B. Parkc, Preparation of alginate beads for floating drug delivery system: Effects of CO₂ gas-forming agents, Int. J. Pharm. 239 (2002) 81–91; DOI: 10.1016/S0378-5173(02)00054-6.10.1016/S0378-5173(02)00054-6Search in Google Scholar

18. V. S. Meka, N. S. Rao, S. A. Sunil, B. J. Ram and K. V. R. Murthy, Statistical optimization of a novel excipient (CMEC) based gastroretentive floating tablet of propranolol HCl and its in vivo buoyancy characterization in healthy human volunteers, DARU J. Pharm. Sci. 20 (2012) 1–12; DOI: 10.1186/1560-8115-20-4.10.1186/1560-8115-20-4351453923226721Search in Google Scholar

19. M. Grassi and G. Grassi, Mathematical modeling and controlled drug delivery: matrix systems, Curr. Drug. Deliv.2 (2005) 97–116; DOI: 10.2174/1567201052772906.10.2174/156720105277290616305412Search in Google Scholar

20. F. Khan, M. S. M. Razzak and M. S. Reza, Preparation and in vitro evaluation of theophylline loaded gastroretentive floating tablets of METHOCEL K4M, Dhaka Univ. J. Pharm. Sci. 7 (2008) 65–69; DOI: 10.3329/dujps.v7i1.1220.10.3329/dujps.v7i1.1220Search in Google Scholar

21. C. Narendra, M. S. Srinath and A. Moin, The study on the effect of formulation variables on in vitro floating time and the release properties of floating drug delivery system by a statistical optimization technique, Chem. Ind. Chem. Engin. Quart.14 (2008) 17–26; DOI: 10.2298/ciceq0801017n.10.2298/CICEQ0801017NSearch in Google Scholar

22. K. K. Satish, K. P. Santhosh, K. N. Nishanth and B. P. Bharghav, Formulation and in vitro evaluation of ofloxacin tablets, J. Pharm. Res. 4 (2011) 3007.Search in Google Scholar

23. R. H. Myers, D. C. Montgomery and C. M. A. Cook, Response Surface Methodology: Process and Product Optimization Using Designed Experiments, 3^rd ed., Wiley, New York 2009, pp. 15–29.Search in Google Scholar

24. V. S. Meka, N. S. Rao, S. A. Sunil, B. J. Ram and K. V. R. Murthy, Thermal sintering: a novel technique used in the design, optimization and biopharmaceutical evaluation of propranolol HCl gastric floating tablets, Drug. Dev. Ind. Pharm.40 (2014) 33–45; DOI: 10.3109/03639045.2012.744416.10.3109/03639045.2012.74441623317339Search in Google Scholar

25. United States Pharmacopeia 29, NF 24, Pharmacopeial Forum. 30 (2006) p. 1474.Search in Google Scholar

26. United States Pharmacopeia 29, NF 25, Tablet friability. Chapter 1216. USP30–NF25, Pharmacopeial Forum. 31 (2007) p. 1735.Search in Google Scholar

27. M. Yasir, M. Asif, A. Bhattacharya and M. Bajpai, Development and evaluation of gastroretentive drug delivery system for theophylline using psyllium husk, Int. J. Chem. Tech. Res. 2 (2010) 792–799.Search in Google Scholar

28. C. Rajveer, B. S. Rathinaraj, M. Fareedullah, G. S. Bangale and G. Shinde, Design and evaluation of ketorolac tromethamine sustained release matrix tablets, Deccan. J. Pharm. Cosmet.1 (2010) 57–71.Search in Google Scholar