<abstract xmlns="http://www.w3.org/1999/xhtml">The aim of this research was to formulate effervescent floating drug delivery systems of theophylline using different release retarding polymers such as ethyl cellulose, Eudragit® L100, xanthan gum and polyethylene oxide (PEO) N12K. Sodium bicarbonate was used as a gas generating agent. Direct compression was used to formulate floating tablets and the tablets were evaluated for their physicochemical and dissolution characteristics. PEO based formulations produced better drug release properties than other formulations. Hence, it was further optimized by central composite design. Further subjects of research were the effect of formulation variables on floating lag time and the percentage of drug released at the seventh hour (<italic>D</italic><italic>7</italic>h). The optimum quantities of PEO and sodium bicarbonate, which had the highest desirability close to 1.0, were chosen as the statistically optimized formulation. No interaction was found between theophylline and PEO by Fourier Transformation Infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) studies.</abstract>

The aim of this research was to formulate effervescent floating drug delivery systems of theophylline using different release retarding polymers such as ethyl cellulose, Eudragit® L100, xanthan gum and polyethylene oxide (PEO) N12K. Sodium bicarbonate was used as a gas generating agent. Direct compression was used to formulate floating tablets and the tablets were evaluated for their physicochemical and dissolution characteristics. PEO based formulations produced better drug release properties than other formulations. Hence, it was further optimized by central composite design. Further subjects of research were the effect of formulation variables on floating lag time and the percentage of drug released at the seventh hour (D7h). The optimum quantities of PEO and sodium bicarbonate, which had the highest desirability close to 1.0, were chosen as the statistically optimized formulation. No interaction was found between theophylline and PEO by Fourier Transformation Infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) studies.

Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology

School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The aim of this research was to formulate effervescent floating drug delivery systems of theophylline using different release retarding polymers such as ethyl...

Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology

Published Online: Mar 07, 2016

Page range: 35 - 51

Accepted: Dec 22, 2014

DOI: https://doi.org/10.1515/acph-2016-0002

Keywords
theophylline, gastroretentive, floating, central composite, PEO N12K

© 2016 Venkata Srikanth Meka et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology

Published Online: Mar 07, 2016

Page range: 35 - 51

Accepted: Dec 22, 2014

DOI: https://doi.org/10.1515/acph-2016-0002

Keywordstheophylline, gastroretentive, floating, central composite, PEO N12K

© 2016 Venkata Srikanth Meka et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
theophylline, gastroretentive, floating, central composite, PEO N12K